Venezuelan Hemorrhagic Fever

Last update 01 Nov 2024

Basic Info

Synonyms

Guanarito haemorrhagic fever, Guanarito hemorrhagic fever, Venezuelan haemorrhagic fever

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Introduction

Venezuelan hemorrhagic fever (VHF), caused by the Guanarito virus, is a viral hemorrhagic disease characterized by fever, headache, arthralgia, sore throat, convulsions, and hemorrhagic manifestations.

100 Clinical Results associated with Venezuelan Hemorrhagic Fever

100 Translational Medicine associated with Venezuelan Hemorrhagic Fever

0 Patents (Medical) associated with Venezuelan Hemorrhagic Fever

Literatures (Medical) associated with Venezuelan Hemorrhagic Fever

20 Feb 2024·Journal of Virology

Development of reverse genetics system for Guanarito virus: substitution of E1497K in the L protein of Guanarito virus S-26764 strain changes plaque phenotype and growth kinetics

Article

Author: Huang, Cheng ; Saijo, Masayuki ; Manning, John T ; Paessler, Slobodan ; Maruyama, Junki ; Saito, Takeshi ; Reyna, Rachel A ; Littlefield, Kirsten ; Taniguchi, Satoshi

Guanarito virus (GTOV) is a rodent-borne virus. GTOV causes fever, prostration, headache, arthralgia, cough, sore throat, nausea, vomiting, diarrhea, epistaxis, bleeding gums, menorrhagia, and melena in humans. The lethality rate is 23.1% or higher. Vero cell-adapted GTOV S-26764 shows a clear cytopathic effect (CPE), whereas the parental virus shows unclear CPE in Vero cells. We generated a reverse genetics system to rescue recombinant GTOVs and found that E1497K in the L protein was responsible for the formation of clear plaques as well as enhanced viral RNA replication and transcription efficiency. This reverse genetic system will accelerate vaccine and antiviral drug developments, and the findings of this study contribute to the understanding of the function of GTOV L as an RNA polymerase.

01 Jan 2022·Uirusu

南米出血熱ウイルスとその感染予防・治療法の最前線

Article

Author: Lee, Meion ; Koma, Takaaki ; Iwasaki, Masaharu ; Urata, Shuzo

South American Hemorrhagic Fever is caused by the Arenavirus, which belong to the Family Arenaviridae, genus mammarenavirus, infection at South America. South American Hemorrhagic Fever includes 1. Argentinian Hemorrhagic fever caused by Junin virus, 2. Brazilian hemorrhagic fever caused by Sabia virus, 3. Venezuelan Hemorrhagic fever caused by Guanarito virus, 4. Bolivian Hemorrhagic fever caused by Machupo virus, and 5. Unassigned hemorrhagic fever caused by Chapare virus. These viruses are classified in New World (NW) Arenavirus, which is different from Old World Arenavirus (ex. Lassa virus), based on phylogeny, serology, and geographic differences. In this review, the current knowledge of the biology and the development of the vaccines and antivirals of NW Arenaviruses which cause South American Hemorrhagic Fever will be described.

01 Nov 2021·New Microbes and New Infections

Should we be concerned about Venezuelan hemorrhagic fever? – A reflection on its current situation in Venezuela and potential impact in Latin America amid the migration crisis

Article

Author: Bonilla-Aldana, D Katterine ; Paniz-Mondolfi, Alberto ; Risquez, Alejandro ; Rodríguez-Morales, Alfonso J ; Suárez, José Antonio

Venezuelan Haemorrhagic Fever is an endemic zoonosis exhibiting a high lethality. Discovered decades ago, it is still causing seasonal hemorrhagic fever outbreaks. With the ongoing migration crisis, transmission and spreading to other countries in Latin America remains a latent threat that should be monitored, particularly in light of recent cases.

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Venezuelan Hemorrhagic Fever

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