Arene Oxide Detoxification Defect

Last update 01 Nov 2024

Basic Info

Synonyms

ARENE OXIDE DETOXIFICATION DEFECT, Arene Oxide Detoxification Defect, 芳烃氧化物解毒缺陷

Introduction-

100 Clinical Results associated with Arene Oxide Detoxification Defect

100 Translational Medicine associated with Arene Oxide Detoxification Defect

0 Patents (Medical) associated with Arene Oxide Detoxification Defect

Literatures (Medical) associated with Arene Oxide Detoxification Defect

01 Mar 2020·Best Practice & Research Clinical AnaesthesiologyQ4 · MEDICINE

Critical care management in patients with acute liver failure

Q4 · MEDICINE

Review

Author: Saner, Fuat H ; Rifaie, Nadja

Acute liver failure (ALF) is defined as severe hepatic dysfunction (marked transaminases elevation, detoxification disorder (jaundice and coagulopathy with international normal ratio (INR) > 1.5), the presence of hepatic encephalopathy, and exclusion of underlying chronic liver disease, and a secondary cause like sepsis or cardiogenic shock. Reasons for ALF include paracetamol and warfarin toxicity, autoimmune and viral (mainly hepatitis B and E) hepatitis, and herbal and dietary supplements. Even in terms of meticulous and careful review of the patient, around 20-30% of the reasons remains unknown. In order of its rarity, a randomized controlled trial could hardly be done. However, because of improved ICU treatment, the mortality, even in the advanced stage of ALF decreased. However, in 5-10% of the cases an emergency transplantation is required. This justifies the treatment of this patient cohort in institutions that can provide this kind of treatment.

01 Jan 1988·Digestive Diseases and SciencesQ3 · MEDICINE

Hepatic detoxification and hepatic function in chronic active hepatitis with and without cirrhosis

Q3 · MEDICINE

Article

Author: D. Müting ; H. Wuzel ; R. Fischer ; J. F. Kalk ; J. Reikowski

The detoxification capacity of the liver in chronic active hepatitis (CAH) without liver cirrhosis (LC) is not sufficiently known. Therefore, we examined, in 156 patients with morphologically proven CAH of different stages, plasma ammonia, free phenols, indican, glucuronic acid and urea synthesis rate as parameters for liver detoxification. We found a significant increase of ammonia, phenols, and indican and a significant decrease of glucuronic acid and urea synthesis rate parallel to the stage of CAH without LC. In 34 CAH patients with complete recovery, a retrospective 10-year follow-up was possible. Parallel to the normalization of liver morphology and general liver tests, detoxification parameters also normalized. However, the detoxification disorders in CAH without LC are mild in nature and do not produce hepatic encephalopathy. Probably, they are caused by a reduced synthesis of the urea-cycle enzymes and of glucuronyltransferase in the liver.

Biomolecules

The Role of Tripartite Motif Family Proteins in Chronic Liver Diseases: Molecular Mechanisms and Therapeutic Potential

Review

Author: Jiang, Meixiu ; Chen, Yinni ; Cao, Xiwen ; Chen, Yuanli

The worldwide impact of liver diseases is increasing steadily, with a consistent upswing evidenced in incidence and mortality rates. Chronic liver diseases (CLDs) refer to the liver function’s progressive deterioration exceeding six months, which includes abnormal clotting factors, detoxification failure, and hepatic cholestasis. The most common etiologies of CLDs are mainly composed of chronic viral hepatitis, MAFLD/MASH, alcoholic liver disease, and genetic factors, which induce inflammation and harm to the liver, ultimately resulting in cirrhosis, the irreversible final stage of CLDs. The latest research has shown that tripartite motif family proteins (TRIMs) function as E3 ligases, which participate in the progression of CLDs by regulating gene and protein expression levels through post-translational modification. In this review, our objective is to clarify the molecular mechanisms and potential therapeutic targets of TRIMs in CLDs and provide insights for therapy guidelines and future research.

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Arene Oxide Detoxification Defect

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