Psittacosis

主要目的：研究空腹及餐后状态下单次口服受试制剂盐酸多西环素片（规格：0.1g，浙江益汉制药有限公司持证）与参比制剂盐酸多西环素片（商品名：Vibramycin®，规格：100mg，持证商：Pfizer Japan Inc.）在健康成年受试者体内的药代动力学，评价空腹及餐后状态下口服两种制剂的生物等效性。 次要目的：研究受试制剂盐酸多西环素片和参比制剂盐酸多西环素片在健康成年受试者中的安全性。

本试验旨在研究单次空腹和餐后口服成都瑞尔医药科技有限公司研制、杭州民生药业股份有限公司生产的盐酸米诺环素胶囊（100 mg）的药代动力学特征；以Pfizer Japan Inc.持证、ファイザー株式会社生产的盐酸米诺环素胶囊（MINOMYCIN®/ミノマイシン®，100 mg）为参比制剂，比较两制剂中药动学参数Cmax、AUC0-t、AUC0-∞，评价两制剂的人体生物等效性。

Zoonoses and arboviroses refer to a group of diseases transmitted from animals to humans, either directly or indirectly (via mosquitoes, ticks or contact with contaminated environments). Most of these diseases are found in certain tropical zones, but global warming and increased international trade are modifying their geographical distribution, with a gradual trend towards temperate regions. A number of these pathogens have already been detected in Occitania, including dengue fever, West Nile, leishmaniasis and Q fever. Given the region's high mosquito population and favorable climatic conditions, other zoonoses have a strong potential to appear in the region, or may already be circulating at a low level. The study focuses on 18 pathogens selected for their potential to emerge and establish themselves in the Occitanie region: Leishmaniasis, Leptospirosis, Brucellosis, Q fever, Rickettsiosis, Tularemia, Psittacosis, Lyme disease, Tick-borne encephalitis, Hantavirus, Hepatitis E virus, Dengue virus, Zika virus, Chikungunya virus, West-Nile virus, Usutu virus, Toscana virus, Crimean-Congo haemorrhagic fever virus.
The aim of the study is to find out whether patients have antibodies against these infectious agents, which would indicate that they have been exposed to them in the past, even in the absence of symptoms.
Describing the circulation of these pathogens will enable to implement appropriate public health measures to avoid the risk of epidemics (mosquito control, informing professionals, etc.), as well as to assess the risk incurred in the workplace and have this risk recognized by the healthcare system.