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Last update 08 May 2025

Caplan Syndrome

Last update 08 May 2025

Basic Info

Synonyms

CAPLAN SYNDROME, COLINET-CAPLAN SYNDROME, Caplan (etiology)

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Introduction

A condition characterized by the presence of RHEUMATOID ARTHRITIS associated with a specific form of pneumoconiosis, often in coal miners and asbestos workers.

Clinical Trials associated with Caplan Syndrome

CTRI/2024/02/062951

/ RecruitingNot ApplicableIIT

Epigenetic profiling of circulating Histone H3 in the patients of rheumatoid arthritis with pulmonary complications: A pilot study of novel proteomics approach

Start Date04 Mar 2024

Sponsor / Collaborator-

ChiCTR2100048802

/ SuspendedNot ApplicableIIT

A prospective cohort study on the treatment of interstitial pneumonia of RA with Peitushengjinjiedutongluo method

Start Date15 Jul 2021

Sponsor / Collaborator

Zhejiang Chinese Medical University

NCT04356066

/ Unknown statusNot ApplicableIIT

CXCL10 As a Biomarker Of Interstitial Lung Disease in Patients With Rheumatoid Arthritis

Rheumatoid arthritis is a chronic inﬂammatory disease that affects the joints, causing symmetric pain, stiffness, swelling, and limited motion and function of multiple joints, its ﬁbro inﬂammatory manifestations may develop in other organs.

Start Date19 Dec 2020

Sponsor / Collaborator

Assiut University

100 Clinical Results associated with Caplan Syndrome

100 Translational Medicine associated with Caplan Syndrome

0 Patents (Medical) associated with Caplan Syndrome

162

Literatures (Medical) associated with Caplan Syndrome

01 Jan 2024·Journal of the Korean Society of Radiology

Caplan Syndrome Mimicking Progressive Massive Fibrosis on CT: A Case Report

Article

Author: Han, Ji-Yeon ; Baek, Jinwook

This report presents a unique case of Caplan syndrome that mimicked accelerated progressive massive fibrosis. The patient, a former coal miner, had been diagnosed with coal worker's pneumoconiosis 15 years prior and had been treated for rheumatoid arthritis for over 20 years. Accelerated progressive massive fibrosis and the development of multiple nodules with cavitation in the basal lungs were subsequently observed on serial CT scans. Here, the CT manifestations of Caplan syndrome are highlighted in a case in which Caplan syndrome mimicked accelerated progressive massive fibrosis.

01 Sep 2023·Mediterranean Journal of Rheumatology

Paraneoplastic Polyarthritis in a Patient with Synchronous Lung and Colorectal Malignancy

Article

Author: Șargarovschi, Egor ; Opriş-Belinski, Daniela ; Cobilinschi, Claudia ; Constantinescu, Alexandra ; Enache, Simona ; Bălănescu, Andra Rodica

Arthritis is an unusual manifestation of paraneoplastic syndrome, appearing in a variety of cancers, including pulmonary and colorectal. It can often pose a diagnostic challenge to physicians, since it may be difficult to distinguish from more commonly encountered rheumatic illnesses. Moreover, synchronous cancers are rare and unexpected in patients with symmetrical polyarthritis. Hypertrophic pulmonary osteoarthropathy is to be considered in patients with polyarthritis and lung neoplasia. The aim of this report is to highlight the case of a patient presenting with paraneoplastic polyarthritis, which led to identifying the presence of underlying synchronous lung and colorectal malignancies. Lymph node biopsy was performed raising suspicion of Caplan's syndrome but lung lobectomy confirmed adenocarcinoma. Rheumatologists should be reacquainted with rheumatic manifestations in malignant diseases.

01 Aug 2023·Current Drug Safety

Treatment with Rituximab in Rheumatoid Pneumoconiosis: A Case Report

Author: Dhia, Kaffel ; Dorra, Ben Nessib ; Wafa, Triki ; Hanene, Ferjani ; Wafa, Hamdi ; Yasmine, Makhlouf ; Kaouther, Maatallah

Background:Caplan's syndrome, also known as rheumatoid pneumoconiosis (RP), is a rare disease associating pneumoconiosis with rheumatoid arthritis (RA). This is one of the rare cases evaluating the effect of Rituximab, which was used initially for the treatment of RA, on pneumoconiosis.Case presentation:In this case report, we described a 21-year long-standing history of pneumoconiosis and its association with RA. A 67-year-old man diagnosed with pneumoconiosis presented with morning stiffness and symmetrical polyarthritis. Laboratory investigations showed high titers of rheumatoid factor (RF) and anti-citrullinated protein antibodies. The diagnosis of RA was established and the patient was put on leflunomide. Then, he was treated with Rituximab, as he did not respond to leflunomide. The patient showed marked improvement as pain and swelling decreased. More importantly, Caplan’s nodules stabilized on chest-computed tomography.Conclusion:The use of rituximab in pneumoconiosis does not alter the evolution of the pulmonary nodules. More trials are needed to establish a treatment consensus for RP.

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Caplan Syndrome

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