Sclerema Neonatorum

Last update 01 Nov 2024

Basic Info

Synonyms

Pre-agonal induration, Sclerema Neonatorum, Sclerema adiposum

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Introduction

A severe, sometimes fatal, disorder of adipose tissue occurring chiefly in preterm or debilitated infants suffering from an underlying illness and manifested by a diffuse, nonpitting induration of the affected tissue. The skin becomes cold, yellowish, mottled, and inflexible.

100 Clinical Results associated with Sclerema Neonatorum

100 Translational Medicine associated with Sclerema Neonatorum

0 Patents (Medical) associated with Sclerema Neonatorum

Literatures (Medical) associated with Sclerema Neonatorum

01 Oct 2023·Skin Health and Disease

Sclerema neonatorum in a premature newborn: A case report

Author: Mouhamad, Manal ; Alhalabi, Rima ; Abudeeb, Julia ; Oun, Youlla ; Alhalabi, Dima ; Kikhia, Judy ; Salloum, Riham

AbstractSclerema neonatorum (SN) is a rare condition of neonatal panniculitis with a poor prognosis and a high fatality rate. It clinically presents as hardening of the skin and subcutaneous adipose tissue extending throughout the body, sparing the fat‐free soles, palms, and genitalia. SN typically affects gravely ill, preterm neonates in the first week of life and diagnosis is often clinical. We report a case of an eight‐day‐old premature infant diagnosed with early‐onset neonatal sepsis who presented with clinical and histopathological features of SN. Despite early treatment of the sepsis with intravenous antibiotics and the SN with a topical corticosteroid cream and moisturiser, the infant died on the twelfth day of life.

01 Jun 2021·Panminerva MedicaQ4 · MEDICINE

Efficacy of vitamin E combined with heparin sodium cream in treatment of scleredema neonatorum

Q4 · MEDICINE

Article

Author: Li, Huanyun ; He, Jiahuan ; Li, Hui ; Xu, Min ; Liu, Tao ; Zhang, Ying

30 Dec 2020·Case Reports in Pediatrics

Sclerema Neonatorum in a Term Infant: A Case Report and Literature Review

Author: Kavuma, Daniel ; Egesa, Walufu Ivan ; Nakalema, Gloria ; Nduwimana, Martin ; Anaya, Amnia Diaz ; Kizito, Mirembe Stephen ; Kumbakulu, Patrick Kumbowi

Sclerema neonatorum (SN) is a rare form of panniculitides with an obscure incidence, aetiology, and pathogenesis. This condition is peculiar to preterm neonates, especially those with comorbidities such as sepsis, congenital anomalies, congenital heart disease, and gastrointestinal and respiratory diseases. Usually, it presents within the first seven days of life, but may develop a few weeks later. Typically, SN manifests with diffuse hardening of the skin and subcutaneous tissues that subsequently bind to the underlying muscle and bone, often beginning in the buttocks, thighs, or trunk, and progressing to other body parts, but sparing the soles, palms, and genitalia. Diagnosis is based on clinical characteristics. It has been associated with a high mortality, despite aggressive use of various treatment modalities such as antibiotics, steroids, fresh blood transfusion, exchange blood transfusion, and intravenous immunoglobins. This is a report of a macrosomic term neonate who presented with typical clinical and histopathological features of SN.

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Sclerema Neonatorum

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