Request Demo

Last update 08 May 2025

Cauda Equina Syndrome

Last update 08 May 2025

Basic Info

Synonyms

CAUDA EQUINA SYNDROME, Cauda Equina Syndrome, Cauda Equina Syndromes

+ [18]

Introduction

Compressive lesion affecting the nerve roots of the CAUDA EQUINA (e.g., compression, herniation, inflammation, rupture, or stenosis), which controls the function of the bladder and bowel. Symptoms may include neurological dysfunction of bladder or bowels, loss of sexual sensation and altered sensation or paralysis in the lower extremities.

Clinical Trials associated with Cauda Equina Syndrome

NCT06566846

/ Not yet recruitingNot ApplicableIIT

Lumbosacral Transitional Vertebra(LSTV ) Prevalence in Egypt Population and Its Association With Lumbar Degeneration :Retrospective Evaluation of Consecutive Abdominal CT Scans

retrospective cross sectional study Study Setting: Cases will be recruited from the recorded data system at the department of diagnostic radiology, Assiut University.

Start Date01 Sep 2024

Sponsor / Collaborator

Assiut University

NCT06416878

/ RecruitingNot ApplicableIIT

Can Brief Perioperative Epidural Electrical Stimulation Improve Recovery of Autonomic Function in Cauda Equina Syndrome

BESCES is a study that aims to explore the feasibility of intraoperative brief epidural electrical stimulation (ES) for patients undergoing routine decompression for cauda equina syndrome. In consenting patients, brief ES will be applied using a CE-marked SCS trial kit once sufficient decompression is achieved. In participants who do not recover function following decompression, brief post-op ES will be applied to see if can facilitate micturition and/or removal of the catheter.
The study will assess:
The feasibility of intervention. If brief ES can facilitate conduction in residual neurons. If brief ES can facilitate neuronal recovery

Start Date15 Feb 2024

Sponsor / Collaborator

The University of Liverpool

NCT05470751

/ CompletedNot Applicable

A Multi-centre Prospective Observational Study of the User Experience of Catheterisation and Quality of Life in Patients Prescribed GentleCath™ for Men Intermittent Catheter With FeelClean™ Technology

Male self catherterisng observational study.

Start Date02 Feb 2023

Sponsor / Collaborator

ConvaTec, Inc.

100 Clinical Results associated with Cauda Equina Syndrome

100 Translational Medicine associated with Cauda Equina Syndrome

0 Patents (Medical) associated with Cauda Equina Syndrome

2,814

Literatures (Medical) associated with Cauda Equina Syndrome

01 May 2025·World Neurosurgery

Causal Association Between Inflammatory Proteins, Inflammatory Cells, and Cauda Equina Syndrome: A Two-Sample Mendelian Randomization

Article

Author: Sun, Kaiqiang ; Sun, Xiaofei ; Shi, Jiangang ; Han, Linhui ; Wang, Yuan ; Xing, Jianpeng ; Zhang, Bin ; Kong, Qingjie ; Wang, Jinyu

BACKGROUNDRecent studies have shown that inflammation plays a crucial role in the progression of cauda equina syndrome (CES). However, the exact cause-and-effect relationship between them is still unclear.METHODSWe used CES data from the FinnGen genome-wide association study (GWAS), containing 329 cases and 408,351 control patients. Inflammatory proteins data were obtained from a large scale GWAS of 14,828 European ancestry participants, and inflammatory cells data were obtained from a GWAS summary of 3757 Sardinians. We chose inverse variance weighted as the main method and the Cochrane Q test to assess heterogeneity in the results. The MR-Egger intercept test and MR pleiotropy residual sum and outliers test were used to evaluate the horizontal pleiotropy, and sensitivity analysis was performed by leave-one-out analysis.RESULTSWe examined robust associations between inflammatory proteins, inflammatory cells, and CES using Mendelian randomization. Two inflammatory proteins and 12 inflammatory cells were found as risk factors for CES: IL-8 and PD-L1; and basophil plasmacytoid dendritic cell, CD86+plasmacytoid dendritic cell, CD62L-plasmacytoid dendritic cell, CD39+secreting Treg, IgD+CD38-B cell, switched memory B cell, IgD+CD24+B cell, CD62L+dendritic cell, CD4+T cell, γδ T cell, and CD33dim HLA DR-myeloid cell. Two inflammatory proteins and 7 inflammatory cells were found as protective factors for CES: IL-10RA and CCL25; and transitional B cell, terminal differentiation double negative T cell, CD28-CD127-CD25++CD8br T cell, IgD+CD38br B cell, CD28+CD45RA-CD8br Treg, IgD+CD38-naive B cell, and granulocyte. Heterogeneity and pleiotropy analysis confirmed the reliability of the results. Our study reveals the causal relationship between inflammatory proteins, inflammatory cells, and CES, offering new insights for the development of future therapeutic drugs and early warning indicators.CONCLUSIONSOur findings extend genetic research to causal analysis between inflammatory proteins, cells, and CES. We found 2 proteins and 12 cells as risk factors and 2 proteins and 7 cells as protective factors. Further investigations are needed to verify whether these inflammation markers can be used to prevent or treat CES.

01 May 2025·Canadian Association of Radiologists Journal

Canadian Association of Radiologists Spine Imaging Referral Guideline

Review

Author: Worrall, James ; Murphy, Amanda ; Michaud, Alan ; Avard, Barb ; Mattar, Andrew ; Dea, Nicolas ; Witiw, Christopher ; Hamel, Candyce ; Schmidt, Matthias ; Vu, Viet ; Margau, Ryan ; Volders, David

The Canadian Association of Radiologists (CAR) Spine Expert Panel is made up of physicians from the disciplines of radiology, emergency medicine, neurology, neurosurgery, physiatry, a patient advisor, and an epidemiologist/guideline methodologist. After developing a list of 10 clinical/diagnostic scenarios, a rapid scoping review was undertaken to identify systematically produced referral guidelines that provide recommendations for one or more of these clinical/diagnostic scenarios. Recommendations from 23 guidelines and contextualization criteria in the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) for guidelines framework were used to develop 22 recommendation statements across the 8 scenarios (one scenario points to the CAR Trauma Referral Guideline and one scenario points to the CAR Musculoskeletal Guideline). This guideline presents the methods of development and the referral recommendations for myelopathy, suspected spinal infection, possible atlanto-axial instability (non-traumatic), axial pain (non-traumatic), radicular pain (non-traumatic), cauda equina syndrome, suspected spinal tumour, and suspected compression fracture. Spondyloarthropathies and spine trauma point to other CAR Diagnostic Imaging Referral Guidelines, Musculoskeletal and Trauma, respectively.

01 May 2025·World Neurosurgery

Percutaneous Endoscopic Transforaminal Lumbar Interbody Fusion with an Expandable Cage for the Treatment of Degenerative Lumbar Spinal Stenosis with Instability

Article

Author: Tang, Jiaguang ; Chen, Bin ; Cheng, Xiaokang ; Chen, Qiaoling

OBJECTIVETo evaluate the safety and efficacy of percutaneous endoscopic transforaminal lumbar interbody fusion (PE-TLIF) with an expandable cage for the treatment of single-level degenerative lumbar spinal stenosis (LSS) with instability.METHODSThe clinical data of 42 patients (14 males and 28 females) with single-level LSS with instability who underwent PE-TLIF from September 2019 to April 2023 were retrospectively reviewed. All the patients underwent a minimum follow-up of 12 months. The demographics and perioperative and clinical outcomes were reviewed on the basis of the visual analog scale score, Oswestry Disability Index, and modified MacNab criteria. The Brantigan criteria were used to assess interbody fusion at the final follow-up.RESULTSThe mean age was 69.57 ± 6.06 (61-81) years. The average surgical time was 157.02 ± 13.80 minutes (range, 140-220 minutes). The mean estimated blood loss was 48.09 ± 15.22 mL (range, 20-80 mL). The preoperative visual analog scale scores for back pain and leg pain were 6.76 ± 0.88 and 6.90 ± 0.91, respectively, and the preoperative Oswestry Disability Index score was 66.47 ± 7.57. The respective values were 1.83 ± 0.44, 1.79 ± 0.52, and 19.76 ± 6.08 at 12 months postoperatively. According to the modified MacNab criteria, 85.71% (36/42) of patients exhibited good-to-excellent outcomes. The interbody fusion rate was 100% at the final follow-up. Two patients had postoperative intraspinal hematomas, one of whom had cauda equina syndrome and underwent reoperation. Two patients with osteoporosis experienced mild cage subsidence. However, their low back pain was significantly relieved, and interbody fusion was detected at the final follow-up.CONCLUSIONSFor patients with single-level LSS with instability, PE-TLIF with an expandable cage under conscious sedation and local anesthesia potentially represents an effective method for treating degenerative LSS with instability.

News (Medical) associated with Cauda Equina Syndrome

06 Feb 2023

·www.prnewswire.com

New Nature Study Concludes Rarity of Severe Chiropractic-related Adverse Events

In a recent issue of Nature Scientific Reports, researchers at Chiropractic Doctors Association of Hong Kong (CDAHK) concluded that serious side effects with spinal manipulative therapy (SMT) were extremely rare. NEW YORK, Feb. 6, 2023 /PRNewswire/ -- Chiropractors utilize spinal manipulative therapy (SMT) as a primary method of patient treatment. In a recent issue of Nature Scientific Reports, Researchers at CDAHK came to the conclusion that serious side effects from SMT were very rare. Fewer than one in one hundred thousand spinal manipulative therapies result in a serious adverse event, according to a retrospective study of nearly one million chiropractic procedures [1]. Continue Reading NEW PUBLICATION IN NATURE CONCLUDES RARITY OF SEVERE SPINAL MANIPULATION THERAPY-RELATED ADVERSE EVENTS. Using information from 30 different clinics in Hong Kong, the researchers were able to identify patients who experienced adverse effects after chiropractic spinal manipulation over the course of 5 years. Complaint records, patient surveys, complaints, and clinician recorded incidents were all mined for information. There were 39 adverse events reported among 960,140 treatment sessions for 54,846 patients; two were grade 3, both involving rib fractures in women aged 60 and up with osteoporosis; and none were grade 4, producing an incidence of grade 3 adverse events of 0.21 per 100,000 treatment sessions (95% CI 0.00, 0.56 per 100,000). Cauda equina syndrome and stroke-related adverse events were not seen. While chiropractic treatment has been found to be a highly effective care for a wide range of musculoskeletal issues, the side effects are extremely rare. Prevalence of serious pathology presenting for chiropractic care is small [2], most of the patients who undergo chiropractic care report only positive changes in their physical and psychological wellbeing. Chiropractic care is a safe and highly effective form of treatment and its side effects are virtually non-existent [3]. Reference: 1. Chu EC, Trager RJ, Lee LY, Niazi IK. A retrospective analysis of the incidence of severe adverse events among recipients of chiropractic spinal manipulative therapy. Sci Rep. 2023 Jan 23;13(1):1254. doi: 10.1038/s41598-023-28520-4. 2. Chu EC, Trager RJ. Prevalence of Serious Pathology Among Adults with Low Back Pain Presenting for Chiropractic Care: A Retrospective Chart Review of Integrated Clinics in Hong Kong. Med Sci Monit. 2022 Sep 27;28:e938042. doi: 10.12659/MSM.938042. 3. Chu EC, Trager RJ, Tao C, Lee LY. Chiropractic Management of Neck Pain Complicated by Symptomatic Vertebral Artery Stenosis and Dizziness. Am J Case Rep. 2022 Oct 19;23:e937991. doi: 10.12659/AJCR.937991. This press release was issued through 24-7PressRelease.com. For further information, visit . SOURCE Chiropractic Doctors Association of Hong Kong (CDAHK)

Analysis

Perform a panoramic analysis of this field.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Cauda Equina Syndrome

Basic Info

Related

Analysis