Last update 08 May 2025

Histiocytosis, Sinus

Basic Info

Synonyms
Destombes Rosai Dorfman Syndrome, Destombes-Rosai-Dorfman Syndrome, Destombes-Rosai-Dorfman症候群
+ [43]
Introduction
Benign, non-Langerhans-cell, histiocytic proliferative disorder that primarily affects the lymph nodes. It is often referred to as sinus histiocytosis with massive lymphadenopathy.

Related

2
Drugs associated with Histiocytosis, Sinus
Cobimetinib Fumarate
Target
MEK1 x MEK2
Mechanism
MEK1 inhibitors [+1]
Active Org.
Hoffmann-La Roche, Inc. [+5]
Originator Org.
Exelixis, Inc.Exelixis, Inc.
Active Indication
Histiocytic Sarcoma [+44]
Inactive Indication
Adenocarcinoma of large intestine [+37]
Drug Highest PhaseApproved
First Approval Ctry. / Loc.
United States
First Approval Date10 Nov 2015
[68Ga] Pentixafor
Target
CXCR4
Mechanism
CXCR4 antagonists
Active Org.
PentixaPharm GmbHPentixaPharm GmbH
 [+2]
Originator Org.
University of IowaUniversity of Iowa
Active Indication
Marginal Zone B-Cell Lymphoma [+10]
Inactive Indication
Primary Central Nervous System Lymphoma [+1]
Drug Highest PhasePhase 3
First Approval Ctry. / Loc.-
First Approval Date20 Jan 1800
10
Clinical Trials associated with Histiocytosis, Sinus
NCT06712810
/ Not yet recruitingPhase 1IIT
MC220806: Phase I Study Evaluating the Efficacy of CSF1R and TAM Receptor or Inhibition in Hematologic Malignancies With Q702, a Small Molecular Inhibitor
NCT06153173
/ RecruitingPhase 2IIT
A Phase II Trial of the MEK Inhibitor Mirdametinib in Histiocytic Disorders
NCT05915208
/ RecruitingNot ApplicableIIT
Histiocytic Disorder Follow-up Study
100 Clinical Results associated with Histiocytosis, Sinus
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100 Translational Medicine associated with Histiocytosis, Sinus
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0 Patents (Medical) associated with Histiocytosis, Sinus
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2,292
Literatures (Medical) associated with Histiocytosis, Sinus
01 Dec 2025Blood Research
Rosai-Dorfman disease disguised as BRAF V600E-positive histiocytosis – a diagnostic pitfall
01 May 2025Pediatric Blood & Cancer
MEK Inhibition With Trametinib for the treatment of MAP2K1‐Mutated Rosai–Dorfman–Destombes Disease Arising from the Nasopharynx in a Paediatric Patient
01 May 2025Clinical Nuclear Medicine
Rosai-Dorfman Disease Mimicking Metastasis to the Spleen From Breast Cancer

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