/ RecruitingNot Applicable Coordination of Rare Diseases at Sanford
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases. This program allows patients and researchers to connect as easily as possible to help advance treatments and cures for rare diseases. The CoRDS team works with patient advocacy groups, individuals and researchers to help in the advancement of research in over 7,000 rare diseases. The registry is free for patients to enroll and researchers to access. Visit sanfordresearch.org/CoRDS to enroll.
100 Clinical Results associated with Episodic Ataxia, Type 4
100 Translational Medicine associated with Episodic Ataxia, Type 4
0 Patents (Medical) associated with Episodic Ataxia, Type 4
01 Aug 2021·Movement Disorders
Gabapentin Relieves Vertigo of Periodic Vestibulocerebellar Ataxia: 3 Cases and Possible Mechanism
Letter
Author: Gazulla, José
01 Aug 2021·Movement Disorders
Reply to: Gabapentin Relieves Vertigo of Periodic Vestibulocerebellar Ataxia: 3 Cases and Possible Mechanism
Letter
Author: Vance, Jeffery M. ; Coin, J. Thaddeus
01 May 2021·Movement DisordersQ1 · MEDICINE
Gabapentin Relieves Vertigo of Periodic Vestibulocerebellar Ataxia: 3 Cases and Possible Mechanism
Q1 · MEDICINE
Article
Author: Vance, Jeffery M. ; Coin, J. Thaddeus
ABSTRACTObjectiveThe aim of this study was to report relief of optokinetic‐triggered vertigo (OKTV) with low‐dose gabapentin in three patients with periodic vestibulocerebellar ataxia [episodic ataxia type 4 (EA4); OMIM 606552].MethodsClinical observations and analysis of video‐recorded eye movements were used before and after gabapentin.ResultsGabapentin relieved vertigo of all three treated patients with EA4, particularly during activities that typically would induce vertiginous symptoms. Two patients reported 8–12 hours of sustained relief after the first 100 mg dose. One has benefited from 100–200 mg TID for 7 years. Video analysis of nystagmus revealed improved target tracking on smooth pursuit and a steadier gaze hold.ConclusionsGabapentin effectively relieved the optokinetic‐triggered vertigo in our patients with EA4. Mechanisms are postulated in terms of known tight gabapentin binding to the Purkinje cell voltage‐gated calcium channel. The observations may offer insight into this rare disease's neuropathology. © 2021 International Parkinson and Movement Disorder Society