Lupus myocarditis

Last update 08 May 2025

Basic Info

Synonyms

Lupus myocarditis, ループス心筋炎, ﾙｰﾌﾟｽｼﾝｷﾝｴﾝ

Introduction-

100 Clinical Results associated with Lupus myocarditis

100 Translational Medicine associated with Lupus myocarditis

0 Patents (Medical) associated with Lupus myocarditis

125

Literatures (Medical) associated with Lupus myocarditis

01 Apr 2025·Rheumatology

Distinctive clinical traits of lupus-related myocarditis: a multicentre retrospective study

Article

Author: Bellocchi, Chiara ; Holopainen, Noora E A ; Pizzetti, Giuseppe ; Esposito, Antonio ; Beretta, Lorenzo ; Dagna, Lorenzo ; Moroni, Luca ; Sala, Simone ; Gerosa, Maria ; Mastropaolo, Francesca ; Cariddi, Adriana ; Ramirez, Giuseppe A ; Argolini, Lorenza M ; De Luca, Giacomo ; Campochiaro, Corrado ; Sartorelli, Silvia ; Caporali, Roberto ; Palmisano, Anna ; Peretto, Giovanni ; Bozzolo, Enrica P ; Arroyo-Sánchez, Daniel

AbstractObjectivesCardiovascular involvement in systemic lupus erythematosus (SLE) is frequent, but little is known about possible distinctive traits of SLE-related myocarditis (myoSLE) in comparison with patients with SLE (onlySLE) or myocarditis alone (onlyMyo).MethodsA retrospective analysis was performed comparing patients with myoSLE (n = 25) from three centres with consecutive patients with onlySLE (n = 279) and onlyMyo (n = 88). SLE patients were dichotomized by disease duration ≤1 vs >1 year into recent onlySLE/early myoSLE vs longstanding onlySLE/late myoSLE. Further stratification into disease duration of 1–5, 5–10 and >10 years was also performed. SLE disease activity index 2000 (SLEDAI-2K) was used to estimate disease activity. Myocarditis was diagnosed through biopsy or MRI.ResultsWomen were significantly more frequent among myoSLE than among onlyMyo (72% vs 43%; P = 0.013). Compared with onlyMyo, myoSLE patients had a higher frequency of conduction abnormalities (22% vs 5%; P = 0.046) and presented with numerically higher frequencies of left ventricular function compromise (48% vs 30%), along with higher pro-brain natriuretic peptide levels. Inflammation markers were higher in myoSLE compared with onlyMyo and with patients with onlySLE with >10 years of disease duration. SLEDAI-2K was significantly higher in late myoSLE than in longstanding onlySLE. Antiphospholipid syndrome was more frequent in myoSLE than in onlySLE. Multivariate analysis showed an association among myoSLE, anti-β-2-glycoprotein I antibodies (aB2GPI, P = 0.014) and a higher number of involved British Isles Lupus Assessment Group domains in patient history (P = 0.003).ConclusionmyoSLE has unique clinical traits compared with other forms of myocarditis and is associated with aB2GPI and a more severe SLE course.

01 Apr 2025·JACC: Case Reports

Peripartum Unmasking of Acute Lupus Myopericarditis

Article

Author: Kersey, Cooper B ; Yang, Eugene ; Balansay, Brianna ; Richardson, Annie

BACKGROUNDThere is a broad differential diagnosis that should be considered when assessing a postpartum patient in cardiopulmonary distress.CASEThe authors present a case of postpartum systemic lupus erythematosus (SLE)-associated myopericarditis causing heart failure with reduced ejection fraction highlighting the challenges of diagnosis and treatment of new-onset heart failure in postpartum patients.DISCUSSIONA unique element of this case was peripartum unmasking of SLE with cardiac involvement. Hormonal changes during pregnancy exacerbate helper T-cell mediated autoimmune diseases, potentially triggering SLE in this patient.TAKE-HOME MESSAGEThis case emphasizes the importance of using cardiac magnetic resonance imaging to determine the etiology of heart failure during the postpartum period and shared decision-making around guideline-directed medical therapy in a lactating patient.

26 Feb 2025·Cureus

A Case of Lupus Myopericarditis in a Young African American Male

Article

Author: Abutineh, Mohamed A ; Sharak, Nazar ; Lodha, Chirag

A 28-year-old African American male presented to the emergency department with a chief complaint of chest pain. He stated that the pain began five days prior to arrival and had not improved despite taking ibuprofen and self-medicating with marijuana. His chest pain was constant and localized to the center of his chest, rating it as a 7/10 in terms of severity. His past medical history included a diagnosis of systemic lupus erythematosus (SLE) three months ago, complicated by pericarditis, for which he had been taking colchicine and prednisone, as well as hydroxychloroquine for maintenance therapy. He stated that he adhered to his treatment regimen without missing a single dosage. Upon cardiac auscultation, he was found to have a pericardial friction rub. His ECG showed signs of PR-segment depression in all leads, ST-elevation in leads V2-V4, as well as sinus tachycardia, raising some concern for myocardial ischemia. His echocardiogram showed no signs of pericardial effusion or left ventricular dysfunction and was otherwise unremarkable. Because of his positional chest pain, diffuse ST-elevation, and elevated troponin, the patient was diagnosed with myopericarditis, thought to be secondary to SLE exacerbation due to no recent illnesses. He was then placed on low-dose prednisone. After four days, his symptoms resolved, and he was discharged with a regimen of 60 mg prednisone daily and 0.5 mg colchicine daily for his pericarditis as well as 10 mg oxycodone for his pain every eight hours. His prednisone was to be tapered with a rheumatologist outpatient, but there was no follow-up at the time of writing this study.

Analysis

Perform a panoramic analysis of this field.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Lupus myocarditis

Basic Info

Related

Analysis