100 Clinical Results associated with Pseudohyperkalemia, Familial, 2, Due to Red Cell Leak
100 Translational Medicine associated with Pseudohyperkalemia, Familial, 2, Due to Red Cell Leak
0 Patents (Medical) associated with Pseudohyperkalemia, Familial, 2, Due to Red Cell Leak
20 Jun 2022·Nederlands tijdschrift voor geneeskunde
[Pseudohyperkalemia: clinical chemistry for the clinician].
Article
Author: de Man, Robert A ; Ramakers, Christian ; Rotmans, Joris I ; Hoorn, Ewout J ; Gritter, Martin
BACKGROUNDHyperkalemia is an electrolyte disorder requiring medical attention because it can cause cardiac arrhythmias. Pseudohyperkalemia is the phenomenon of an elevated potassium concentration that is present in the blood sample but not in the patient. Pseudohyperkalemia can be caused by hemolysis, leukocytosis, thrombocytosis, seasonal pseudohyperkalemia, potassium release from muscle cells due to fist clenching during venipuncture, and contamination due to blood withdrawal from an intravenous line over which potassium was administered. Rarer causes include EDTA contamination and familial pseudohyperkalemia.CASE DESCRIPTIONA 23-year old woman was admitted with ascites due to polycythemia vera and essential thrombocytosis for which hydroxycarbamide was started. The reported serum potassium concentrations were 6.1 and 6.8 mmol/l. The use of spironolactone was discontinued and she was treated with sodium polystyrene sulfonate and insulin-glucose infusion. The serum potassium concentration only decreased on the ninth day of admission, when the thrombocyte count was normalizing. A diagnosis of pseudohyperkalemia due to thrombocytosis was established.CONCLUSIONKnowledge of the causes of pseudohyperkalemia and interaction between the clinician and clinical chemist aids in the differentiation between true hyperkalemia and pseudohyperkalemia and may prevent unnecessary diagnostics and harmful treatment.
01 Feb 2001·British Journal of HaematologyQ2 · MEDICINE
Familial pseudohyperkalaemia Chiswick: a novel congenital thermotropic variant of K and Na transport across the human red cell membrane
Q2 · MEDICINE
Article
Author: Suzanne E. Coles ; Helen Jarvis ; Margaret C. Chetty ; Anna Nicolaou ; Philip G. Haines ; Julie Fisher ; Charles Crawley ; Gordon W. Stewart
Two families with inherited abnormalities in Na and K transport across the red cell membrane are described. Both presented with ‘pseudohyperkalaemia’ as a result of loss of K from the red cells on storage at room temperature. Routine haematology was essentially normal, except for macrocytosis in one family. Studies of the temperature dependence of the passive leak to K showed a novel shoulder pattern with a minimum at 25°C, a maximum at 10°C, followed by a further fall. As in other cases of red cell‐based pseudohyperkalaemia, the abnormal temperature dependence of this ‘leak’ flux could be held to account for the loss of K from the cells at room temperature. These cases represent a novel variant of the temperature dependence of the passive leak of K and Na across the red cell membrane, and can be classified as a mild, non‐haemolytic form of the group known as the hereditary stomatocytosis and allied disorders’.
