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Last update 08 May 2025

Kyphoscoliosis 1

Last update 08 May 2025

Basic Info

Synonyms

KYPHOSCOLIOSIS 1, KYPSC1, Kyphoscoliosis 1

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Introduction-

Clinical Trials associated with Kyphoscoliosis 1

NCT05146193

/ RecruitingNot Applicable

AI-Powered Scoliosis Auto-Analysis System Multicenter Development and Validations

The investigators aim to use artificial intelligence (AI) to help clinicians in diagnosing and assessing spinal deformities.

Start Date01 May 2022

Sponsor / Collaborator

The University of Hong Kong

[+9]

NCT04601363

/ RecruitingNot ApplicableIIT

Personalized Spine Study Group (PSSG) Registry of Patients With Personalized Spine Rod Implantation

The primary objective of the study is a data collection initiative. The study will collect clinical and radiographic outcomes of patients implanted with patient specific rods. The secondary objective is to collect clinical and radiographic outcomes of patients with hardware as a control cohort to the patient-specific rods.

Start Date29 Oct 2020

Sponsor / Collaborator

University of Colorado Denver

NCT04536909

/ Active, not recruitingNot Applicable

Indication and Treatment of Adult Kyphoscoliosis

Degeneration, iatrogenic-/idiopathic causes and fractures can lead to kypho- scoliotic deformities potentially resulting in pain and loss of function. The surgical strategies rely on surgeon preferences and type of deformity as well as clinical symptoms. The complication rate of surgical treatment is high. The aim of this study is to elucidate the indications for surgical treatment of kyphoscoliosis and evaluate the effectiveness of surgical and non-surgical outcome clinically and radiologically.
The primary outcome for the PROMs and x-ray is at 12 months, but the investigators will also follow the patients with the PROMs and x-rays after 2,5 and 10 years.

Start Date01 Jan 2020

Sponsor / Collaborator

University of Bergen

[+4]

100 Clinical Results associated with Kyphoscoliosis 1

100 Translational Medicine associated with Kyphoscoliosis 1

0 Patents (Medical) associated with Kyphoscoliosis 1

Literatures (Medical) associated with Kyphoscoliosis 1

01 Jun 2020·World NeurosurgeryQ4 · MEDICINE

Radiologic Outcomes and Complication Analysis of the Posterior Vertebral Column Resection in the Treatment of Previously Operated Severe Kyphoscoliosis: A Retrospective Case Series

Q4 · MEDICINE

Article

Author: Polat, Ayşe Esin ; Atıcı, Yunus ; Çarkçı, Engin ; Erdoğan, Sinan ; Benli, İsmet Teoman ; Polat, Barış ; Demiröz, Serdar

OBJECTIVEThe aim of this study was to evaluate the radiologic outcomes and complication analysis of posterior vertebral column resection (PVCR) performed on previously operated patients with severe kyphoscoliosis (SK).METHODSTwelve patients (6 men and 6 women) with SK underwent PVCR. The mean age of the patients preoperatively was 16 years (range, 10-26 years). The mean follow-up period was 5.3 years (range, 2-7 years). Previous surgeries included posterior growth arrest in 3 patients, hemivertebrectomy in 4 patients, and posterior fusion in 5 patients. The sagittal plane parameters and coronal parameters were measured in the preoperative, in the early postoperative, and during the last follow-up stages. Complications were also noted.RESULTSThe mean thoracic scoliosis Cobb angle was 76.8° (range, 35°-142°) preoperatively, 37.8° (range, 5°-80°) early postoperatively, and 41.5° (range, 11°-80°) during the last follow-up (P < 0.0001). The mean thoracic kyphosis angle was 84.7° (range, 23°-132°) preoperatively, 50.3° (range, 25°-78°) early postoperatively, and 48.5° (range, 25°-80°) during the last follow-up (P = 0.0032). Complications occurred in 5 patients (41.7%); a hemothorax in 1 patient, rod fracture in 3 patients, and permanent neurologic deficit in 1 patient. Temporary loss of neuromonitoring motor evoked potentials developed in 2 patients during deformity correction.CONCLUSIONSPVCR provides effective correction in patients with SK. However, expected surgical correction of a deformity may not always be achieved because of intraoperative neuromonitoring changes. Furthermore, PVCR can lead to a large number of major complications in patients with SK who have undergone previous spinal surgery.

01 Jan 2014·Annals of the Rheumatic DiseasesQ1 · MEDICINE

Patients with non-Jo-1 anti-tRNA-synthetase autoantibodies have worse survival than Jo-1 positive patients

Q1 · MEDICINE

Article

Author: Diane Carol Koontz ; Rohit Aggarwal ; Dana P Ascherman ; Mary Lucas ; Noreen Fertig ; Chester V Oddis ; Elaine Cassidy

OBJECTIVETo compare the cumulative survival and event free survival in patients with Jo-1 versus non-Jo-1 anti-tRNA synthetase autoantibodies (anti-synAb).METHODSAnti-synAb positive patients initially evaluated from 1985 to 2009 were included regardless of the connective tissue disease (CTD) diagnosis. Clinical data were extracted from a prospectively collected database and chart review. Survival between Jo-1 and non-Jo-1 was compared by log rank and Cox proportional hazards methods.RESULTS202 patients possessed anti-synAb: 122 Jo-1 and 80 non-Jo-1 (35 PL-12; 25 PL-7; 9 EJ; 6 KS; 5 OJ). The diagnoses at first visit for Jo-1 and non-Jo-1 patients were myositis in 83% and 40.0%, overlap or undifferentiated CTD in 17% and 47.5%, and systemic sclerosis in 0% and 12.5%, respectively (p<0.001). The median delay in diagnosis was 0.4 years in Jo-1 patients versus 1.0 year in non-Jo-1 patients (p<0.001). The most common causes of death in the overall cohort were pulmonary fibrosis in 49% and pulmonary hypertension in 11%. The 5- and 10-year unadjusted cumulative survival was 90% and 70% for Jo-1 patients, and 75% and 47% for non-Jo-1 patients (p<0.005). The hazard ratio (HR) of non-Jo-1 patients compared with Jo-1 patients was 1.9 (p=0.01) for cumulative and 1.9 (p=0.008) for event free survival from diagnosis. Age at first diagnosis and diagnosis delay but not gender, ethnicity and CTD diagnosis influenced survival.CONCLUSIONSNon-Jo-1 anti-synAb positive patients have decreased survival compared with Jo-1 patients. The difference in survival may be partly attributable to a delay in diagnosis in the non-Jo-1 patients.

01 Jan 2011·Prenatal DiagnosisQ3 · MEDICINE

Fetal spinal anomalies in a first‐trimester sonographic screening program for aneuploidy

Q3 · MEDICINE

Review

Author: Amy E. Wong ; Waldo Sepulveda ; David E. Fauchon

AbstractObjectivesTo review the sonographic features of spinal anomalies in first‐trimester fetuses presenting for screening for chromosomal abnormalities.MethodsFetuses with a spinal abnormality diagnosed prenatally or postnatally that underwent first‐trimester sonographic evaluation at our institution had their clinical information retrieved and their sonograms reviewed.ResultsA total of 21 fetuses complied with the entry criteria including eight with body stalk anomaly, seven with spina bifida, two with Vertebral, Anal, Cardiac, Tracheal, Esophageal, Renal, and Limb (VACTERL) association, and one case each of isolated kyphoscoliosis, tethered cord, iniencephaly, and sacrococcygeal teratoma. One fetus with body stalk anomaly and another with VACTERL association also had a myelomeningocele, making a total of nine cases of spina bifida in our series. Five of the nine (56%) cases with spina bifida, one of the two cases with VACTERL association, and the cases with tethered cord and sacrococcygeal teratoma were undiagnosed in the first trimester. Although increased nuchal translucency was found in seven (33%) cases, chromosomal analysis revealed only one case of aneuploidy in this series.ConclusionsFetal spinal abnormalities diagnosed in the first trimester are usually severe and frequently associated with other major defects. The diagnosis of small defects is difficult and a second‐trimester scan is still necessary to detect most cases of spina bifida. Copyright © 2010 John Wiley & Sons, Ltd.

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