Prolonged use of wastewater irrigation in peri-urban agriculture has increased levels of heavy metals (HMs) in soil, raising concerns regarding both food safety and human health.To address this issue, the effectiveness of agro-waste derived bioashes (ADB), specifically rice husk ash (RHA) and sugarcane bagasse ash (SBA), was investigated as soil amendment materials to immobilize HMs in soil and reduce their accumulation in crops.The aim of the present study was to evaluate the effects of RHA and SBA on HM uptake, growth, yield, nutrient quality, and seed metabolite profiles of wheat (Triticum aestivum L. cv. HUW 234) crop grown in HM contaminated soils, along with associated health risks.Results revealed that SBA significantly and effectively reduced Cr, Ni, Cu, Zn, and Cd accumulation in wheat seeds (13.5%, 33.8%, 17.6%, 7.8%, and 10.0%, resp.), more compared to RHA (6.8%, 16.9%, 8.8%, 3.9%, and 5.0%) with maximum accumulation in roots followed by shoots and least in seeds.Health risk assessments showed that the estimated daily intake (EDI) of HMs was found highest for Zn and lowest for Cd in both the children and adults consuming wheat seeds, with hazard quotient values above a unit for all the HMs.The present study concludes that SBA could be effectively used as a superior soil amendment to reduce HM toxicity in soil-wheat system, associated human health risks and to promote sustainable agriculture in peri-urban areas.

10 Jan 2025·ACS Pharmacology & Translational Science

Safe and Orally Bioavailable Inhibitor of Serine Palmitoyltransferase Improves Age-Related Sarcopenia

Article

Author: Potluri, Vijay ; De Masi, Alessia ; Lima, Tanes ; Auwerx, Johan ; Morel, Jean-David ; Poisson, Johanne ; Rodriguez-Lopez, Sandra ; Jain, Suresh ; Benegiamo, Giorgia ; Daskalaki, Ioanna

The accumulation of ceramides and related metabolites has emerged as a pivotal mechanism contributing to the onset of age-related diseases. However, small molecule inhibitors targeting the ceramide de novo synthesis pathway for clinical use are currently unavailable. We synthesized a safe and orally bioavailable inhibitor, termed ALT-007, targeting the rate-limiting enzyme of ceramide de novo synthesis, serine palmitoyltransferase (SPT). In a mouse model of age-related sarcopenia, ALT-007, administered through the diet, effectively restored muscle mass and function compromised by aging. Mechanistic studies revealed that ALT-007 enhances protein homeostasis in Caenorhabditis elegans and mouse models of aging and age-related diseases, such as sarcopenia and inclusion body myositis (IBM); this effect is mediated by a specific reduction in very-long chain 1-deoxy-sphingolipid species, which accumulate in both muscle and brain tissues of aged mice and in muscle cells from IBM patients. These findings unveil a promising therapeutic avenue for developing safe ceramide inhibitors to address age-related neuromuscular diseases.

01 Dec 2024·Journal of Hazardous Materials

N-coordinated iron sites dispersed in porous carbon frameworks to activate peroxymonosulfate for efficient sulfisoxazole degradation and real hospital wastewater decontamination

Article

Author: Xiong, Zhaokun ; Gu, Lingyun ; Yu, Chunxiu ; Long, Quan ; Shi, Hongle ; Chen, Kexin ; Zhang, Li ; Wu, Zelin ; Lai, Bo ; Wu, Yi

Herein, an N-coordinated Fe site dispersed in porous carbon frameworks (Fe-NC) fabricated from zeolitic imidazolate frameworks encapsulated with iron acetylacetonate (Fe(acac)₃ @ZIFs) was employed to activate peroxymonosulfate (PMS) for the attenuation of sulfisoxazole (SIZ) and treating real hospital wastewater. The constructed Fe-NC/PMS system exhibited good catalytic stability for SIZ degradation, maintaining excellent degradation performance over multiple cycles with virtually no leaching. The quenching experiments, electron paramagnetic resonance (EPR) capture analyses, and semi-quantitative measurements showed that singlet oxygen (¹O₂) and high-valent metal-oxo species were mainly responsible for SIZ degradation by Fe-NC/PMS. Significantly, ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS) was used to trace 134 pharmaceutical contaminants in real hospital wastewater. Effective degradation was achieved for 87 % of the pharmaceutical contaminants by the Fe-NC/PMS process. Seventy-four pharmaceutical contaminants were eliminated. Taken together, this work successfully established the Fe-NC/PMS technology using the developed iron-based materials and explored its application to real hospital wastewater treatment, providing an eco-friendly and effective strategy for treating wastewater.

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