Delving into the Latest Updates on CKD-845 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Testosterone (Chong Kun Dang Pharmaceutical)

Target

AR

Action-

Mechanism

AR agonists(Androgen Receptor agonists), Testosterone replacements

Therapeutic Areas

Endocrinology and Metabolic Disease

Active Indication-

Inactive Indication

Hypogonadism

Originator Organization

Chong Kun Dang Pharmaceutical Corp.

Active Organization-

Inactive Organization

Chong Kun Dang Pharmaceutical Corp.

License Organization-

Drug Highest PhasePendingPhase 1

First Approval Date-

Regulation-

WS-9659 A, a novel phenazine, produced by a Streptomyces sp., had testosterone 5 alpha-reductase inhibition activity on rat, dog and human prostates. However, WS-9659 A did not show any inhibitory activities for aldose reductase on rabbit lenses and lactate dehydrogenase on pig hearts. WS-9659 A was a competitive inhibitor against testosterone 5 alpha-reductase on rat prostates by use of testosterone as a substrate. Radio receptor binding assay of androgen receptor of rat prostates revealed that WS-9659 A had no affinity for this receptor. WS-9659 A was tested subcutaneously in immature castrated rats to confirm its effect on the growth of the ventral prostates induced by testosterone propionate.

01 Nov 1954·EXPERIMENTAL BIOLOGY AND MEDICINE

Effects of Hormone Administration on Serum Protein Patterns.

Article

Author: Karen Irvine ; Cornelia Hoch-Ligeti

cf. C.A. 48, 4680b.In rats the total serum-protein concentration was increased by cortisone administration but not by the other hormones tested.Adrenocorticotropin decreased serum albumin; testosterone, hydrocortone, and cortisone increased it.Insulin increased the concentration of α₁-globulins.Estrogen produced an increase in α₂-globulins, which then appeared as a double band on the electropherogram.Hydrocortone, but not cortisone, depressed the γ-globulin concentrationProgesterone and thyroxine had no effect on the serum-protein pattern.

100 Deals associated with CKD-845

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