Last update 06 Jun 2026

VU0476406

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
VU0476406
Target
M4 receptor
Action
modulators
Mechanism
M4 receptor modulators(Muscarinic acetylcholine receptor M4 modulators)
Therapeutic Areas
Nervous System DiseasesCongenital DisordersEndocrinology and Metabolic Disease+ [1]
Active Indication
Huntington DiseaseParkinson DiseaseSchizophrenia
Inactive Indication-
Originator Organization
AstraZeneca PLCAstraZeneca PLCVanderbilt UniversityVanderbilt University
Active Organization
Vanderbilt UniversityVanderbilt UniversityAstraZeneca PLCAstraZeneca PLC
Inactive Organization-
License Organization-
Drug Highest PhasePreclinical
First Approval Date-
Regulation-

Structure/Sequence

Molecular FormulaC21H18FN5OS
InChIKeyBPGQEZBPFDQHIA-UHFFFAOYSA-N
CAS Registry1451993-12-6

Related

100 Clinical Results associated with VU0476406
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100 Translational Medicine associated with VU0476406
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100 Patents (Medical) associated with VU0476406
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1
Literatures (Medical) associated with VU0476406
01 Jun 2017Bioorganic & medicinal chemistry lettersQ4 · MEDICINE
Optimization of M4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology
Q4 · MEDICINE
100 Deals associated with VU0476406
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Huntington DiseasePreclinical
United States
Vanderbilt UniversityVanderbilt University
01 Jun 2017
Huntington DiseasePreclinical
New Zealand
AstraZeneca PLCAstraZeneca PLC
01 Jun 2017
Parkinson DiseasePreclinical
United States
Vanderbilt UniversityVanderbilt University
01 Jun 2017
Parkinson DiseasePreclinical
New Zealand
AstraZeneca PLCAstraZeneca PLC
01 Jun 2017
SchizophreniaPreclinical
United States
Vanderbilt UniversityVanderbilt University
01 Jun 2017
SchizophreniaPreclinical
New Zealand
AstraZeneca PLCAstraZeneca PLC
01 Jun 2017
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Clinical Result

Indication
Phase
Evaluation
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Clinical Trial

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Approval

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Regulation

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