Last update 08 Oct 2025

AZD6621

Overview

Basic Info

Drug Type
Bispecific T-cell Engager (BiTE)
Synonyms-
Target
CD8 x STEAP2
Action
stimulants, inhibitors
Mechanism
CD8 stimulants(Cluster of differentiation 8 stimulants), STEAP2 inhibitors(STEAP2 metalloreductase inhibitors)
Therapeutic Areas
NeoplasmsUrogenital Diseases
Active Indication
Metastatic Prostate CarcinomaProstatic Cancer
Inactive Indication-
Originator Organization
AstraZeneca PLCAstraZeneca PLC
Active Organization
AstraZeneca PLCAstraZeneca PLC
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with AZD6621
NCT07192614
/ RecruitingPhase 1/2
A Phase I/II Open-label, Dose Escalation and Dose Expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of AZD6621, a T Cell-engaging Antibody That Targets STEAP2, CD3, and CD8 in Adult Participants With Metastatic Prostate Cancer
100 Clinical Results associated with AZD6621
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100 Translational Medicine associated with AZD6621
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100 Patents (Medical) associated with AZD6621
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100 Deals associated with AZD6621
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Prostate CarcinomaPhase 2
United States
AstraZeneca PLCAstraZeneca PLC
30 Sep 2025
Metastatic Prostate CarcinomaPhase 2
China
AstraZeneca PLCAstraZeneca PLC
30 Sep 2025
Metastatic Prostate CarcinomaPhase 2
Japan
AstraZeneca PLCAstraZeneca PLC
30 Sep 2025
Metastatic Prostate CarcinomaPhase 2
South Korea
AstraZeneca PLCAstraZeneca PLC
30 Sep 2025
Prostatic CancerPreclinical
United Kingdom
AstraZeneca PLCAstraZeneca PLC
28 Apr 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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