Objective To explore the polymorphisms of SLCO1B1 and ApoE genes in patients with hyperlipidemia and their correlations with serum lipid levels.Methods We retrospectively analyzed levels of of triglyceride (TG), total cholesterol (TC), and low d. lipoprotein cholesterol (Low d.), and highdensity lipoprotein cholesterol (HDL-C) and other clin. data in 115 patients with hyperlipidemia admitted between Jan., 2018 and Apr., 2019.The patients with hyperlipidemia were used as the observation group, while 106 healthy volunteers were selected as the control group.The distribution of SLCO1B1 and ApoE gene polymorphisms in the observation group and the control group, as well as the differences in serum lipid levels between the SLCO1B1 and ApoE gene phenotype groups within the observation group were analyzed.The partial correlation anal. was conducted between SLCO1B1 and ApoE gene and blood lipid levels in patients with hyperlipidemia.Results Distribution of SLCO1B1 gene polymorphism was identified as following:the frequency of A gene phenotype in the observation group and the control group were 77.39% and 82.08%, resp., which were the highest within the group, and the C gene phenotype frequency was the lowest in the group A, B and C; there was no significant difference in the frequency of gene phenotype between the groups (P>0.05); ApoE gene polymorphism distribution was identified as following: the E3 gene phenotype frequencies of the observation group and the control group were 63.48% and 76.42%, resp., which were the highest within the group, and the E3 and E4 gene phenotype frequencies in the observation group were compared with the healthy volunteers in the control group and showed a significant differences (P<0.05); The TG, TC, and LDL-C of the SLCO1B1 gene phenotype in patients with hyperlipidemia were higher than those in group B and C.The HDL-C in group B was higher than that in group A and C, but for the phenotypes of TG, TC, there was no significant difference in serum lipid index between LDL-C and HDLC (P>0.05); There were no significant differences in the concentrations of TG, LDL-C and HDL-C between ApoE gene phenotypes E2, E3 and E4 in patients with hyperlipidemia (P>0.05), but the TC concentration in E4 group was significantly higher than that in E2 group and E3 group (P<0.05); Partial correlation anal. showed that there was no significant correlation between SLCO1B1 gene polymorphism and serum lipid levels (P>0.05), and there was no correlation between ApoE gene polymorphism and TG and HDL-C concentrations (P>0.05), however, it was correlated with the concentrations of TC (r=0.36) and LDL-C (r=0.28) (P<0.05).Conclusion The frequency distributions of SLCO1B1 and ApoE gene in patients with hyperlipidemia are significantly different.The distribution of ApoE gene polymorphism and blood lipid levels are related, which has great clin. values for the selection of lipid-lowering drugs and dietary intervention treatment options.
