The proposed method for estimating monoamines (dopamine) is relatively simple, eliminates the use of a large quantity of material, and is a modification of the A. V. Sakharov and D. A. Sakharov procedure (1968) which uses aqueous H₂CO.The modification involved treatment of hypothalamus sections with 10% H₂CO solution (prepared in Ringer-Locke solution of pH 7.4) for 15 min at 4°.After removing excess H₂CO, the preparations were dried over P₂O₅ at 45° for 2 h, kept in nonluminescent immersion oil at 60° for 15 min, and then examined under a luminescent microscopy.Quant. determination of monoamine (dopamine) in the arcuate nucleus of the hypothalamus was done with indirect fluorometry (preparations were photographed under standard conditions under a luminescent microscope, and the negatives were inspected with a microphotometer).Applicability of the method is demonstrated by measuring changes in monoamine during the estrus cycle.

Klinicheskaya Meditsina (Moscow, Russian Federation)

The question of a thiamine and riboflavin deficiency in acute and chronic diseases of the liver

Author: Sudakova, S. A.

The vitamin B₁ (I) and B₂ (II) deficiency existing in the organism in acute parenchymatous hepatitis was demonstrated in an investigation of the vitamin excretion after intramuscular injection of large amounts of I (10 mg.) and II (5 mg.) either separately or together.Sometimes the excretion of II and I following the administration of both was considerably higher than that following their administration separately.A certain parallel was found to exist between the excretion of I and II and the severity of the disease.There was also a definite relation between the disturbance of the excretion of II and I following their combined administration and the condition of the detoxicating function of the liver.The excretion of bilirubin did not coincide completely with that of the vitamins.A definite I and II deficiency was observed in cases of cirrhosis of the liver.The excretion of these vitamins was practically 0 before administration of large doses of them and was still low after such administration.It increased considerably during treatment with a diet rich in protein together with large amounts of II, I, and vitamin C.The symptoms of acute and chronic diseases of the liver parenchyma are thus explained in part by the I and II deficiency, and therapy with these vitamins is indicated.

Gigiena Truda i Professional'nye Zabolevaniya

Chronic experimental effect of potassium sulfate and a potassium-magnesium sulfate fertilizer on animals

Author: Khodykina, T. M.

Chronic toxicity symptoms are described in rats following their 4-h daily exposure for 4 mo to K sulfate and K Mg sulfate (5.5-15 mg/m³).Both materials were polytropic and caused irritation of the lung and upper respiratory tract.Prolonged exposure to the materials also affected oxidation-reduction processes, internal organs, and also the immune system.A concentration of 15 mg/m³ is recommended as the threshold concentration for these materials.

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