Like most organisms, plants have endogenous biological clocks that coordinate internal events with the external environment. We used high-density oligonucleotide microarrays to examine gene expression in Arabidopsis and found that 6% of the more than 8000 genes on the array exhibited circadian changes in steady-state messenger RNA levels. Clusters of circadian-regulated genes were found in pathways involved in plant responses to light and other key metabolic pathways. Computational analysis of cycling genes allowed the identification of a highly conserved promoter motif that we found to be required for circadian control of gene expression. Our study presents a comprehensive view of the temporal compartmentalization of physiological pathways by the circadian clock in a eukaryote.

01 Jun 2000·Plant Physiology

National Science Foundation-Sponsored Workshop Report: “The 2010 Project”Functional Genomics and the Virtual Plant. A Blueprint for Understanding How Plants Are Built and How to Improve Them

Author: Raikhel, Natasha V. ; Dangl, Jeffrey ; Okada, Kiyotaka ; Martienssen, Rob ; Briggs, Steve ; Caboche, Michel ; Guerinot, Mary Lou ; Ecker, Joseph R. ; Chory, Joanne ; Coruzzi, Gloria M. ; Grant, Sarah ; Cook, Doug ; Somerville, Chris R. ; Weigel, Detlef ; Henikoff, Steven

Although future developments in a rapidly emerging field can be difficult to predict, some projections and evaluations are helpful in planning for the development of community resources and other initiatives that may facilitate progress. To make these projections and evaluations, a group of

01 Jan 2000·Yeast

Proteome Profiling—Pitfalls and Progress

Author: Haynes, Paul A. ; Yates III, John R.

In this review we examine the current state of analytical methods in proteomics. The conventional methodology using two-dimensional electrophoresis gels and mass spectrometry is discussed, with particular reference to the advantages and shortcomings thereof. Two recently published methods which offer an alternative approach are presented and discussed, with emphasis on how they can provide information not available via two-dimensional gel electrophoresis. These two methods are the isotope-coded affinity tags approach of Gygi et al. and the two-dimensional liquid chromatography–tandem mass spectrometry approach as presented by Link et al. We conclude that both of these new techniques represent significant advances in analytical methodology for proteome analysis. Furthermore, we believe that in the future biological research will continue to be enhanced by the continuation of such developments in proteomic analytical technology.

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