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Last update 08 May 2025

Amersham Biosciences AB

Private Company|Sweden

Last update 08 May 2025

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Translational Medicine

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100 Clinical Results associated with Amersham Biosciences AB

0 Patents (Medical) associated with Amersham Biosciences AB

Literatures (Medical) associated with Amersham Biosciences AB

Expanded bed adsorption for integrated primary recovery

Author: Hjorth, Rolf A.

Expanded bed adsorption (EBA) is a technique to clarify, concentrate and partially purify biopharmaceutical products from various feedstocks in one unit operation.This results in higher product recoveries and shorter process times compared to other approaches.The development of improved adsorbents for EBA allowing faster processes and product binding without feedstock dilution has increased the over-all productivity.In addition, the availability of EBA columns which overcome the problem of feedstock clogging has made the process significantly more robust.These columns are scalable to production scale with maintained hydrodynamic performance.Increased knowledge on the interaction of various feedstocks with EBA adsorbents and the development of methodol. to monitor such interactions has made process development easier and more predictable.Furthermore, the better understanding of the behavior of different EBA processes has made it possible to develop general guidelines their for application.This presentation will cover some aspects on development of efficient and robust EBA processes.

Hierarchically structured porous polydivinylbenzene beads

Author: Meyer, Ulrika ; Larsson, Anders

In adsorbent beads for process chromatog., a hierarchical pore structure is expected to give improved mass transport of target mols. such as proteins etc.The structure should have a network of large feeder pores extending from the bead surface and subdividing into smaller pores with a large accessible surface where the adsorption can take place.To prepare beads with this structure, we have conducted suspension polymerizations where dispersions of inorganic template particles (ground limestone, magnesium hydroxide, wollastonite) in solutions of a crosslinking monomer (divinylbenzene)and a porogenic diluent (Et hexanol) are emulsified in an aqueous phase, polymerised and treated with acids to dissolve the template particles.The resulting polydivinylbenzene beads have a large-pore structure (microns) formed by the cavities of the template particles as well as a fine-pore structure (nanometers) derived from the porogen-induced phase separation during polymerizationElectron microscopy and mercury porosimetry data show that the two pore structures are connected both to the exterior and to each other, provided that the template particle surfaces are treated to get an appropriate degree of hydrophobicity.

Stimulus-responsive polymers used in chromatographic separation

Author: Kjellgren, Anna ; Palmgren, Ronnie ; Wulff, Marie ; Rudstedt, Asa ; Van Alstine, Jim

In the chromatog. separation of peptides, proteins, and other biol. mols., and when culturing cells on particulate media, it is frequently necessary to avoid the use of organic solvents or high salt concentrations in the mobile phase, which can cause sample denaturation.The complete avoidance of organic solvents is also advantageous for environmental reasons.Polymers that display a physicochem. response to stimuli have been utilized widely by a variety of scientists (e. g., Okano et. al. , Hoffman et. al. ) for drug delivery systems, cell culture substrates, and bioconjugates.Stimuli studied to date include chem. substances, and changes in temperature, pH, light and elec. fields.However, there have been few reports on the use of stimulus-responsive polymers in chromatog. separations, where altering phys. conditions strongly affects surface properties of the stationary phase.We have covalently attached different stimulus-responsive polymers to a support matrix.These new matrixes were then characterised and chromatog. evaluated.The responsive media show different separation behavior than regular media.

100 Deals associated with Amersham Biosciences AB

100 Translational Medicine associated with Amersham Biosciences AB

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Amersham Biosciences AB

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Pipeline Snapshot as of 07 Nov 2025

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Translational Medicine

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