ZPBP2

Last update 08 May 2025

Basic Info

Synonyms

MGC41930, zona pellucida binding protein 2, Zona pellucida-binding protein 2

+ [3]

Introduction

Is implicated in sperm-oocyte interaction during fertilization.

100 Clinical Results associated with ZPBP2

100 Translational Medicine associated with ZPBP2

0 Patents (Medical) associated with ZPBP2

Literatures (Medical) associated with ZPBP2

18 Oct 2023·The Journal of infectious diseases

Association of Asthma Risk Alleles With Acute Respiratory Tract Infections and Wheezing Illnesses in Young Children.

Article

Author: Forsström, Ville ; Toivonen, Laura ; Waris, Matti ; Pedersen, Casper-Emil T ; Peltola, Ville ; Jartti, Tuomas ; Homil, Kiara ; Bønnelykke, Klaus

BACKGROUNDGenome-wide association studies have identified several risk alleles for early childhood asthma, particularly in the 17q21 locus and in the cadherin-related family member 3 (CDHR3) gene. Contribution of these alleles to the risk of acute respiratory tract infections (ARI) in early childhood is unclear.METHODSWe analyzed data from the STEPS birth-cohort study of unselected children and the VINKU and VINKU2 studies on children with severe wheezing illness. Genome-wide genotyping was performed on 1011 children. We analyzed the association between 11 preselected asthma risk alleles and the risk of ARIs and wheezing illnesses of various viral etiologies.RESULTSThe asthma risk alleles in CDHR3, GSDMA, and GSDMB were associated with an increased rate of ARIs (for CDHR3, incidence rate ratio [IRR], 1.06; 95% confidence interval [CI], 1.01-1.12; P = .02), and risk allele in CDHR3 gene with rhinovirus infections (IRR, 1.10; 95% CI, 1.01-1.20, P = .03). Asthma risk alleles in GSDMA, GSDMB, IKZF3, ZPBP2, and ORMDL3 genes were associated with wheezing illnesses in early childhood, especially rhinovirus-positive wheezing illnesses.CONCLUSIONSAsthma risk alleles were associated with an increased rate of ARIs and an increased risk of viral wheezing illnesses. Nonwheezing and wheezing ARIs and asthma may have shared genetic risk factors. Clinical Trials Registration. NCT00494624 and NCT00731575.

13 Mar 2023·Biology of Reproduction

Quantitative proteomic analysis uncovers protein-expression profiles during gonadotropin-dependent folliculogenesis in mice

Article

Author: Xu, Xueqiang ; Niu, Shudong ; Wang, Yibo ; Wang, Peike ; Chai, Junyi ; Mu, Lu ; Zhang, Shuo ; Li, Zhen ; Zhang, Yan ; Zhang, Hua ; Wang, Haoran ; Li, Lingyu ; Jia, Longzhong

AbstractOvarian follicle is the basic functional unit of female reproduction, and is composed of oocyte and surrounding granulosa cells. In mammals, folliculogenesis strictly rely on gonadotropin regulations to determine the ovulation and the quality of eggs. However, the dynamic changes of protein-expressing profiles in follicles at different developmental stages remain largely unknown. By performing mass-spectrometry-based quantitative proteomic analysis of mouse follicles, we provide a proteomic database (~3000 proteins) that covers three key stages of gonadotropin-dependent folliculogenesis. By combining bioinformatics analysis with in situ expression validation, we showed that our proteomic data well reflected physiological changes during folliculogenesis, which provided potential to predict unknown regulators of folliculogenesis. Additionally, by using the oocyte structural protein zona pellucida protein 2 as the internal control, we showed the possibility of our database to predict the expression dynamics of oocyte-expressing proteins during folliculogenesis. Taken together, we provide a high-coverage proteomic database to study protein-expression dynamics during gonadotropin-dependent folliculogenesis in mammals.

01 Feb 2022·Pediatric Allergy and ImmunologyQ1 · MEDICINE

17q12‐21 risk‐variants influence cord blood immune regulation and multitrigger‐wheeze

Q1 · MEDICINE

Article

Author: Böck, Andreas ; Unterschemmann, Sandra ; Laubhahn, Kristina ; Kunze, Sonja ; Schedel, Michaela ; Zeber, Kathrin ; Schaub, Bianca

AbstractBackgroundChildhood wheeze represents a first symptom of asthma. Early identification of children at risk for wheeze related to 17q12‐21 variants and their underlying immunological mechanisms remain unknown. We aimed to assess the influence of 17q12‐21 variants and mRNA expression at birth on the development of wheeze.MethodsChildren were classified as multitrigger/viral/no wheeze until six years of age. The PAULINA/PAULCHEN birth cohorts were genotyped (n = 216; GSA‐chip). mRNA expression of 17q21 and innate/adaptive genes was measured (qRT‐PCR) in cord blood mononuclear cells. Expression quantitative trait loci (eQTL) and mediation analyses were performed. Genetic variation of 17q12‐21 asthma‐single nucleotide polymorphisms (SNPs) was summarized as the first principal component (PC1) and used to classify single SNP effects on gene expression as (locus)‐dependent/independent eQTL SNPs.ResultsCore region risk variants (IKZF3, ZPBP2, GSDMB, ORMDL3) were associated with multitrigger wheeze (OR: 3.05–5.43) and were locus‐dependent eQTL SNPs with higher GSDMA, TLR2, TLR5, and lower TGFB1 expression. Increased risk of multitrigger wheeze with rs9303277 was in part mediated by TLR2 expression. Risk variants distal to the core region were mainly locus‐independent eQTL SNPs with decreased CD209, CD86, TRAF6, RORA, and IL‐9 expression. Distinct immune signatures in cord blood were associated either with multitrigger wheeze (increased innate genes, e.g., TLR2, IPS1, LY75) or viral wheeze (decreased NF‐κB genes, e.g., TNFAIP3 and TNIP2).ConclusionLocus‐dependent eQTL SNPs (core region) associated with increased inflammatory genes (primarily TLR2) at birth and subsequent multitrigger wheeze indicate that early priming and imbalance may be crucial for asthma pathophysiology. Locus‐independent eQTL SNPs (mainly distal region, rs1007654) may be involved in the initiation of dendritic cell activation/maturation (TRAF6) and interaction with T cells (CD209, CD86). Identifying potential mechanistic pathways at birth may point to critical key points during early immune development predisposing to asthma.

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ZPBP2

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