TAS2R60

Last update 08 May 2025

Basic Info

Synonyms

T2R56, T2R60, TAS2R60

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Introduction

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).

100 Clinical Results associated with TAS2R60

100 Translational Medicine associated with TAS2R60

0 Patents (Medical) associated with TAS2R60

Literatures (Medical) associated with TAS2R60

01 May 2023·Heliyon

Bioinformatic analysis identifies GPR91 as a potential key gene in brain injury after deep hypothermic low flow

Article

Author: Jirong, Qi ; Jia, An ; Kede, Wu ; Xuming, Mo ; Puwei, Song ; Jiali, Xu ; Zhuoga, Deqin ; Patel, Nishant

Explore the transcription change of brain ischemia and reperfusion injury after deep hypothermic low flow.The data from PRJNA739516 and GSE104036 were obtained for the differentially expressed genes identification, functional enrichment anal., gene set enrichment anal., protein-protein interaction construction and hub gene identification.Oxygen and glucose deprivation model was set to validate the hub gene and explore the detailed brain injury mechanism.Interleukin, immunol. response, NF-κB signaling pathway, G protein-coupled receptor signaling pathway and NLRP inflammatory are functional pathway were enriched in differentially expressed genes anal.Sucnr1, Casr, Cxcr4, C5ar1, Tas2r41, Tas2r60 and Hcar2 were identified and verified in the OGD model.Knocking down GPR91 reduces the inflammatory response after OGD and GPR91 may be involved in the inflammatory pre-reaction through the synergistic activation of NF-κB, NLRP3, and IL-1β resp.Our study found that Interleukin, immunol. response, NF-κB signaling pathway, G protein-coupled receptor signaling pathway and NLRP inflammatory are all associated with brain ischemia and reperfusion injury after deep hypothermic low flow and GPR91 can activate NF-κB/NLRP3 pathway and trigger the release of IL-1β in this progress.

01 Dec 2022·iScience

Genetic variants in taste genes play a role in oral microbial composition and severe early childhood caries

Article

Author: de Jesus, Vivianne Cruz ; Hu, Pingzhao ; Chelikani, Prashen ; Schroth, Robert J ; Mittermuller, Betty-Anne

Severe early childhood caries (S-ECC) is a multifactorial disease with strong evidence of genetic inheritance. Previous studies suggest that variants in taste genes are associated with dental caries due to the role of taste proteins in mediating taste preferences, oral innate immunity, and important host-microbial interactions. However, few taste genes have been investigated in caries studies. Therefore, the associations of genetic variants in sweet, bitter, umami, salt, sour, carbonation, and fat taste-related genes with S-ECC and plaque microbial composition (16S and ITS1 rRNA sequencing) were evaluated. The results showed that sixteen variants in seven taste genes (SCNN1D, CA6, TAS2R3, OTOP1, TAS2R5, TAS2R60, and TAS2R4) were associated with S-ECC. Twenty-one variants in twelve taste genes were correlated with relative abundances of bacteria or fungi. These results suggest that S-ECC risk and composition of the plaque microbiome can be partially influenced by genetic variants in genes related to taste sensation.

01 May 2013·Biochemical and Biophysical Research CommunicationsQ3 · BIOLOGY

Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol

Q3 · BIOLOGY

Article

Author: Sophie Thalmann ; Maik Behrens ; Wolfgang Meyerhof

A complete understanding of bitterness perception requires identification of cognate bitter substances for all human bitter taste receptors (TAS2Rs). However, so far, no agonists have been identified for five of the 25 TAS2Rs, i.e., TAS2R41, TAS2R42, TAS2R45, TAS2R48 and TAS2R60. Due to substantial genetic variability several haplotypes exist for most bitter receptor genes. For some of the deorphaned TAS2Rs, haplotypes have been identified coding for proteins with severely impaired or even lacking receptor function, proposing that the use of non-functional receptor variants in previous investigations accounted for the failure to identify cognate bitter agonists for the orphan TAS2Rs. In the present report we reasoned that at least one out of the major genetically encoded TAS2R variants is functional. Therefore, we expressed the major haplotypes of the five orphan TAS2Rs in our functional assay and challenged the cells with 106 bitter compounds. Chloramphenicol was identified as agonist for TAS2R41. Further studies revealed that TAS2R41 is a 'specialist' receptor highly selective for this antibiotic. None of the other TAS2R variants responded to any of the 106 compounds, suggesting that the use of non-functional variants does not explain the failure to identify cognate agonists for the other four TAS2Rs. Probably, these TAS2Rs are highly selective for bitter substances absent in our compound library.

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TAS2R60

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