BZW1

Last update 08 May 2025

Basic Info

Synonyms

5MP2, Basic leucine zipper and W2 domain-containing protein 1, basic leucine zipper and W2 domains 1

+ [5]

Introduction

Translation initiation regulator which represses repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:29470543, PubMed:34260931). Enhances histone H4 gene transcription but does not seem to bind DNA directly (PubMed:11524015).

100 Clinical Results associated with BZW1

100 Translational Medicine associated with BZW1

0 Patents (Medical) associated with BZW1

Literatures (Medical) associated with BZW1

01 Apr 2025·Arab Journal of Gastroenterology

Retraction notice to “miR-129-2-3p inhibits colon cancer cell proliferation by down-regulating the expression of BZW1” [Arab J. Gastroenterol. 25 (2024) 42−50]

Article

Author: Gao, Hengfei ; Wang, Meng ; Wang, Feng ; Ji, Kangkang ; Song, Peng ; Ren, Yan ; Shao, Lihua ; Tao, Liang

01 Jan 2025·The journal of contemporary dental practice

Bone Remodeling Optimization in Orthodontics: Harnessing Periodontal Ligament Cell-derived Exosomes and Anti-inflammatory Compounds.

Article

Author: Alhazmi, Anwar Shawqi

AIM AND BACKGROUNDExosomes transport biological information between cells and can influence periodontal tissue remodeling. Particularly, the periodontal ligament cells (PDLCs) receive mechanical stimuli and transmit them via exosomes to osteoblasts and assist in tissue remodeling during the orthodontic treatment.MATERIALS AND METHODSThis study uses computational methods to examine the effects of mechanical force-induced PDLC-transported exosomal micro RNA (miRNA) on osteoblast cells and to identify potential adjuvant therapies during orthodontic treatment.RESULTSAs a result of the investigation, 29 miRNAs were overrepresented in the PDLC-derived exosome, and when transported to osteoblasts, it regulates 3,768 mRNA targets, forming a vital gene interaction network. From the network, the crucial cluster was extracted, which plays a role in FoxO signaling, PI3K-Akt signaling, Ras signaling, and MAPK signaling pathways. Further, the cluster analysis with Cytohubba plug-in identified the basic leucine zipper and W2 domains 1 (BZW1) gene as a key target of miRNAs (hsa-let-7d-5p, hsa-miR-101-3p, and hsa-miR-15b-5p) in osteoblast cells. Molecular docking (MD) of 2,696 anti-inflammatory compounds against BZW1 indicates the least binding energy of -6.33 kcal/mol for C₂₁H₂₄N₄O₂ that effectively interacts with BZW1 protein. Further molecular mechanics-generalized born model and solvent accessibility analysis showed a free-binding energy of -34.56 kcal/mol for the C₂₁H₂₄N₄O₂-BZW1 complex. Finally, molecular dynamics simulation confirms stable confirmation of the C₂₁H₂₄N₄O₂-BZW1 complex.CONCLUSIONOur study stipulates the molecular mechanisms that occurred in osteoblast cells upon mechanical stimuli in PDLC, which is critically useful to the development of adjuvant therapeutic molecules for the benefit of orthodontic treatment.CLINICAL SIGNIFICANCEThe crucial mechanism by which exosomes deliver miRNAs to the osteoblast cells capable of inhibiting the significant genes/mRNAs could benefit orthodontic treatment. How to cite this article: Alhazmi AS. Bone Remodeling Optimization in Orthodontics: Harnessing Periodontal Ligament Cell-derived Exosomes and Anti-inflammatory Compounds. J Contemp Dent Pract 2025;26(1):77-85.

01 Dec 2024·Cell Reports Medicine

CD97 maintains tumorigenicity of glioblastoma stem cells via mTORC2 signaling and is targeted by CAR Th9 cells

Article

Author: Yuan, Zheng ; Choi, Sun Il ; Park, Jong Bae ; Shi, Bingyang ; Lin, Weiwei ; Zhang, Qi ; Zhou, Shuchang ; Yin, Jinlong ; Deng, Yilin ; Liu, Meichen ; Guo, Meixia ; Niu, Rui ; Jin, Xiong ; Chai, Tianran ; Kim, Sung Soo

Glioblastoma (GBM) stem cells (GSCs) contribute to poor prognosis in patients with GBM. Identifying molecular markers is crucial for developing targeted therapies. Here, we identify cluster of differentiation 97 (CD97) as an optimal GSC surface antigen for potential targeting by chimeric antigen receptor (CAR) T cell therapy through in vitro antibody screening. CD97 is consistently expressed in all validated patient-derived GSCs and positively correlated with known intracellular GSC markers. Silencing CD97 reduces GSC tumorigenicity-related activities, including self-renewal, proliferation, and tumor progression. Transcriptome analysis reveals that CD97 activates mTORC2, leading to AKT S473 phosphorylation and enhanced expression of the downstream genes ARHGAP1, BZW1, and BZW2. Inhibiting mTORC2 with JR-AB2-011 suppresses GSC tumorigenicity and downstream gene expression. We develop CD97-CAR T helper (Th) 9 cells, which exhibit potent cytotoxic effects in vitro and extend survival in mice. These findings suggest that CD97 is a promising GSC-enriched antigen and that targeting it with CAR Th9 cells offers a potential therapeutic strategy for GBM.

Analysis

Perform a panoramic analysis of this field.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

BZW1

Basic Info

Related

Analysis