RNU12

Last update 08 May 2025

Basic Info

Synonyms

RNA, U12 small nuclear, RNU12, RNU12-1

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Introduction-

100 Clinical Results associated with RNU12

100 Translational Medicine associated with RNU12

0 Patents (Medical) associated with RNU12

Literatures (Medical) associated with RNU12

01 Oct 2023·Molecular Cell

RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression

Article

Author: Seidman, Jason S ; Link, Verena M ; Abe, Yohei ; Mueller, Jasmine R ; Ouyang, Zhengyu ; Sakai, Juro ; Downes, Michael ; Manolagas, Stavros C ; Hamakubo, Takao ; Evans, Ronald M ; Almeida, Maria ; Schlachetzki, Johannes C M ; Taylor, Havilah ; Prohaska, Thomas A ; Cobo, Isidoro ; Kadonaga, James T ; Jepsen, Kristen ; Rosenfeld, Michael G ; Fan, Weiwei ; Spann, Nathanael J ; Yeo, Gene W ; Kofman, Eric R ; Resende-Coelho, Ana ; Glass, Christopher K ; Stender, Joshua D ; Cruz-Becerra, Grisel ; Sakai, Mashito ; Ponte, Filipa

The nuclear receptor co-repressor (NCoR) complex mediates transcriptional repression dependent on histone deacetylation by histone deacetylase 3 (HDAC3) as a component of the complex. Unexpectedly, we found that signaling by the receptor activator of nuclear factor κB (RANK) converts the NCoR/HDAC3 co-repressor complex to a co-activator of AP-1 and NF-κB target genes that are required for mouse osteoclast differentiation. Accordingly, the dominant function of NCoR/HDAC3 complexes in response to RANK signaling is to activate, rather than repress, gene expression. Mechanistically, RANK signaling promotes RNA-dependent interaction of the transcriptional co-activator PGC1β with the NCoR/HDAC3 complex, resulting in the activation of PGC1β and inhibition of HDAC3 activity for acetylated histone H3. Non-coding RNAs Dancr and Rnu12, which are associated with altered human bone homeostasis, promote NCoR/HDAC3 complex assembly and are necessary for RANKL-induced osteoclast differentiation in vitro. These findings may be prototypic for signal-dependent functions of NCoR in other biological contexts.

09 May 2023·Scientific reports

RNU12 inhibits gastric cancer progression via sponging miR-575 and targeting BLID.

Article

Author: Zou, Changyan ; He, Huocong ; Lin, Xiandong ; Lin, Xinyi ; Wang, Shaoli ; Liao, Jin-Rong ; Zhang, Lurong ; Su, Ying ; Zheng, Xiongwei ; Huang, Tao ; Hu, Dan

Gastric cancer (GC) is one of the major causes of cancer deaths with 5-year survival ratio of 20%. RNU12 is one of long noncoding RNAs (lncRNAs) regulating the tumor progression. However, how RNU12 affecting GC is not clear. qRT-PCR was utilized for determining the RNU12 expression in cell lines, 113 cases of paired gastric cancer (GC) and their adjacent normal gastric tissues. The biofunction alterations of RNU12 were assessed by its overexpression or knockdown in GC cells. MTT and cloning assay were assayed for the cell proliferation, the flow cytometry for the detection of cell cycle and the wound healing assay (WHA) and transwell invasion assay (TIA) for examining the migration and invasion of cells. The expressions of a set of genes related proliferation and migration were investigated with the Western Blotting (WB). RNA immunoprecipitation (RIP), biotinylated RNA pull-down and dual luciferase reporter tests were used to detect the interactions of RNU12 with miR-575/BLID. The in vivo proliferation and migration ability of RNU12 infected cells were determined in zebrafish system. This study revealed that RNU12 inhibited proliferation, invasion and metastasis by sponging of miR-575 and regulating the downstream BLID and modulated EMT of GC cells. The RNU12/miR-575/BLID axis is likely to be the prognosis biomarkers and drug targets of GC.

01 Jan 2022·Journal of Neural TransmissionQ4 · MEDICINE

Sex differences in schizophrenia: a longitudinal methylome analysis

Q4 · MEDICINE

Article

Author: Al-Chalabi, Nzaar ; Fatemi, Ali Bani ; Gerretsen, Philip ; De Luca, Vincenzo ; Adanty, Christopher ; Qian, Jessica ; Graff, Ariel

DNA methylation analysis at the genome-wide level is a useful tool to explore potential sex differences in SCZ patients. The primary aim of the current study was to identify differentially methylated regions of DNA between males and females with schizophrenia. We collected DNA samples from 134 schizophrenia patients to measure genome-wide methylation at single-base resolution in 96 males and 38 females. We further repeated the analysis in 13 subjects (9 females, 4 males) to confirm the sex differences and to reduce the effect of potential confounders. The longitudinal methylation analysis found significant replication of several genes across the genome. These genes included RFTN1, TLE1, DAZL, PRR4, UTP14C, RNU12, and LOC644649. The overall results showed robust association between autosomal CpG sites and sex. Longitudinal methylation analysis can be used as internal replication to confirm epigenetic variants that are stable over time.

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RNU12

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