MYO1H

Last update 08 May 2025

Basic Info

Synonyms

FLJ37587, MYO1H, myosin IH

+ [2]

Introduction

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).

100 Clinical Results associated with MYO1H

100 Translational Medicine associated with MYO1H

0 Patents (Medical) associated with MYO1H

Literatures (Medical) associated with MYO1H

01 Jan 2025·Brazilian Journal of Psychiatry

Association between methyl-CpG-binding domain protein 5 gene and depressive symptoms in Mexican population: Results from MxGDAR/Encodat cohort

Article

Author: Genis-Mendoza, Alma Delia ; Nicolini, Humberto ; Bustos-Gamiño, Marycarmen ; Medina-Mora, María Elena ; Villatoro-Velá, Jorge Ameth ; Camarena, Beatriz ; Sanabrais-Jiménez, Marco Antonio ; Gutiérrez-López, María de Lourdes ; Martínez-Magaña, José Jaime ; Aguilar-García, Alejandro

OBJECTIVETo explore the association between 75 candidate genes previously reported in subjects with anxiety symptoms (AS) and depressive symptoms (DS) in a Mexican cohort.METHODSThe sample included 2012 individuals from the Mexican Genomic Database for Addiction Research (MxGDAR/Encodat) cohort, 198 showed AS, 266 DS, 66 anxiety and depressive symptoms (ADS), and 1482 healthy controls. The DI-PAD screening questionnaire was used to evaluate lifetime AS and DS. The sample was genotyped with the commercial microarray PsychArray BeadChip. We identified 707 SNPs of 75 genes previously associated with AS and DS. PLINK's logistic regression approach was performed.RESULTSThe analysis showed association between the rs2437092 (p=3.89x10-5) of LAMA and rs11066591 (p=4.06x10-5) of MYO1H with anxiety and depressive symptomatology. Additionally, rs7578002 (p=7.9x10-6) and rs1234428 (p=1.94x10-5) of MBD5 found association with DS. However, after adjustment for age, sex, and the three genetic principal components, only the association of rs7578002 (p=5.85x10-5) and rs1234428 (p=8.15x10-5) of MBD5 with DS remained.CONCLUSIONSOur study replicated the association between MBD5 and DS. The MBD5 protein is involved in gene silencing, suggesting its potential implication in the development of DS in the Mexican population.

01 Nov 2022·American Journal of Orthodontics and Dentofacial Orthopedics

Single nucleotide polymorphisms MYO1H 1001 C>T SNP (rs3825393) is a strong risk factor for mandibular prognathism

Article

Author: Glisic, Branislav ; Milosevic, Olga ; Carkic, Jelena ; Vucic, Ljiljana ; Milasin, Jelena ; Juloski, Jovana ; Nikolic, Nadja

INTRODUCTIONMandibular prognathism (MP) is a common craniofacial disorder of Class III malocclusion that causes esthetic and functional problems. Class III malocclusion diversity is influenced by both environmental and genetic factors. Single nucleotide polymorphisms (SNPs) in genes involved in craniofacial morphogenesis, bone and cartilage development, and metabolism, could play a role as predisposing factors. The present study aimed to establish a potential association between MATN1 -1878 A>G (rs1149048), MYO1H 1001 C>T (rs3825393), and BMP-4 538 A>G (rs17563) SNPs and MP in Serbian population.METHODSThe study included 110 participants: 55 patients with Class III malocclusion diagnosed with MP and 55 with Class I malocclusion. The 3 SNPs were analyzed using the polymerase chain reaction-restriction fragment length polymorphism method.RESULTSThe genotype frequency of MYO1H showed a highly significant difference between patients and controls. Heterozygous carriers of the T allele had an almost 3-fold increase in odds for the development of MP (odds ratio, 2.79; 95% confidence interval, 1.26-6.19; P = 0.010). No association could be established between MATN1 and BMP-4 polymorphisms and MP.CONCLUSIONSOur results support the concept of gene polymorphisms as risk modulators in mandibular prognathism development, although only the association between MYO1H and MP was found in Serbian patients with Class III malocclusion.

01 Oct 2022·Saudi Journal of Biological Sciences

The association of polymorphisms in BMP2/MYO1H and skeletal Class II div.1 maxillary and mandibular dimensions. A preliminary ‘report

Article

Author: Hussein, Ali S ; Porntaveetus, Thantrira ; Abid, Mushriq

IntroductionThe genetic impact directly or indirectly predefines maxillofacial dimensions, potentially leading to an inappropriate relationship of the jaws and subsequently skeletal malocclusion. Previous studies focused mainly on genetic polymorphisms and class III malocclusion. This study was set out to investigate the association between genetic polymorphisms in two genes BMP2 (rs235768) and MYO1H (rs11066446) with Class II division 1 malocclusion, skeletal variation in vertical plane, and maxillary and mandibular jaws length.Subjects and methodsSixty patients classified as Skeletal Class I (n = 30) and Class II division 1 (n = 30) were recruited. DNA was extracted from saliva and analyzed by Sanger sequencing. Lateral cephalometric radiographs were measured for the anterio-posterior relationship of maxillary and mandibular arch using digital tracing. Hardy-Weinberg equilibrium analysis of genotype frequencies was performed using Chi-square test to compare genotype distribution among groups and multiple logistic regression analysis adjusted by gender was also performed.ResultsThe rs235768 polymorphism in BMP2 was associated with hypodivergent face, increased maxillary length, and decreased mandibular length. Meanwhile, the rs11066446 polymorphism in MYO1H was associated with decreased mandibular length. New polymorphism was identified in MYO1H (rs10850090) in association with decreased mandibular length.ConclusionA potential association between polymorpisms in BMP2 rs235768 and MOY1H rs11066446 and rs10850090 and Class II division 1 skeletal malocclusion related phenotypes exists, however, the degree of it has to be further investigated and yet to be discovered.

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