EXOC

Last update 08 May 2025

Basic Info

Synonyms-

Introduction-

100 Clinical Results associated with EXOC

100 Translational Medicine associated with EXOC

0 Patents (Medical) associated with EXOC

1,036

Literatures (Medical) associated with EXOC

01 May 2025·iScience

Subcellular targets and recognition mechanism of Ralstonia solanacearum effector RipE1

Article

Author: Zhang, Ning ; Marinos, Sotiris ; Sarris, Panagiotis F ; Martin, Gregory B ; Michalopoulou, Vassiliki A ; Kountourakis, Nikos ; Kokkinidis, Michael ; Kotsaridis, Konstantinos ; Tsakiri, Dimitra

Some plant NLRs carry unusual integrated protein domains (IDs) that mimic host targets of pathogen effectors. RipE1 is a core Ralstonia solanacearum Type III effector with a predicted cysteine protease activity that activates defense responses in resistant plants. In this study, we used a library of NLR-IDs as an investigative tool to screen for potential host-cell targets of RipE1. Based on these findings and the effector's localization, we identified two plant membrane trafficking components as RipE1's subcellular targets. Depending on its protease activity, RipE1 promotes the degradation of both exocyst complex subunit Exo70B1 and its known interactor RPM1-interacting protein-4 (RIN4), a known plant immunity regulator. RipE1 protease activity is recognized by the RIN4-guarding NLR Pseudomonas tomato race 1 (Ptr1) in Nicotiana benthamiana. Overall, the data presented here, along with the existing literature, suggest a possible link between RipE1 activity upon the host secretion machinery and its NLR-mediated recognition.

01 May 2025·Developmental & Comparative Immunology

EXOC8 of Epinephelus coioides involved in SGIV infection via innate immunity and apoptosis

Article

Author: Zhang, Ze-Peng ; Jiang, Yu-Feng ; Lan, Yin-Mei ; Huang, Wei ; Chen, Zi-An ; Sun, Hong-Yan ; Li, Qi-Yin ; Lin, Yun-Xiang ; Huang, Cui-Fen ; Qin, Qi-Wei

The exocyst complex (EXOC) plays a major role in the extracellular secretion of organisms. In this study, EXOC8, a member of the EXOC family, was characterized from Epinephelus coioides,an important economical important fish in southern China and Southeast Asia, and its role response to viral infection was explored. The full length of E. coioides EXOC8 is 3091 bp including a 2061 bp open reading frame (ORF) encoding 686 amino acids, with a molecular mass of 79037.42 Da. The mRNA of E. coioides EXOC8 can be detected in all of the tissues examined with different levels. E. coioides EXOC8 is distributed in the cytoplasm. The expression of E. coioides EXOC8 was up-regulated during Singapore grouper iridovirus (SGIV) infection, an important pathogen of E. coioides. Overexpressing E. coioides EXOC8 significantly promoted the formation of cytopathic effects (CPE) caused by SGIV infection and the expressions of SGIV key genes MCP, VP19, LITAF and ICP18; but significantly inhibited the activities of NF-κB/AP-1 promoter, apoptosis induced by SGIV, and the expressions of inflammatory factors (IL-6,IL-8, IL-1β and TNF-α) in E. coioides. The results demonstrated that E. coioides EXOC8 may be involved in SGIV infection, providing a theoretical basis for clearing the mechanisms of viral infection in fish.

01 Apr 2025·Theoretical and Applied Genetics

A major QTL region associated with powdery mildew resistance in leaves and fruits of the reconstructed garden strawberry

Article

Author: Rehman, Attiq Ur ; Hytönen, Timo ; Davik, Jahn ; Strandén, Ismo ; Schulman, Alan H ; Karhu, Saila ; Haikonen, Tuuli ; Kaseva, Janne ; Karisto, Petteri ; Rantanen, Marja

AbstractKey messageMultiple QTLs for powdery mildew resistance were identified in a pre-breeding population derived from the octoploid progenitor species of garden strawberry, including a stable major novel factor on chromosome 3B.AbstractPowdery mildew (PM), caused by the biotrophic fungal pathogen Podosphaera aphanis, poses an increasing threat to garden strawberry (Fragaria × ananassa) production worldwide. While a few commercial cultivars exhibit partial resistance, fungicide application remains essential for managing PM outbreaks. However, breeding offers a more sustainable approach for controlling PM. A better understanding of the genetics of resistance is required for informed breeding strategies, e.g. through identifying novel resistance factors derived from the progenitor species of garden strawberry, F. chiloensis and F. virginiana. We conducted genome-wide association (GWA) and multivariate analyses in a reconstructed (ReC) strawberry population to investigate PM resistance under natural infection. Leveraging multi-year field trial data and 20,779 single-nucleotide polymorphism markers, we identified a novel major quantitative trait locus (QTL) on chromosome 3B, designated as q.LPM.Rec-3B.2, that was consistently associated with high PM resistance in both leaves and fruits. Greenhouse validation with a subset of the ReC population confirmed that this QTL region was stable across field and greenhouse environments. Promising candidate genes for resistance, including two for MLO and one for EXO70, were identified within this major QTL. In addition, multi-locus GWA models and non-additive GWA revealed additional resistance QTLs on multiple chromosomes. Despite previous challenges in breeding for robust PM resistance due to its quantitative nature and complex genetic control, our results provide valuable insights into resistance-contributing QTL regions already existing in strawberry, novel wild-derived resistance QTLs not previously known, candidate genes, and pre-breeding germplasm carrying resistance traits as resources for future genome-informed breeding efforts.

Analysis

Perform a panoramic analysis of this field.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

EXOC

Basic Info

Related

Analysis