MT-TS1

Last update 08 May 2025

Basic Info

Synonyms

mitochondrially encoded tRNA-Ser (UCN) 1, MT-TS1, MTTS1

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Introduction-

100 Clinical Results associated with MT-TS1

100 Translational Medicine associated with MT-TS1

0 Patents (Medical) associated with MT-TS1

230

Literatures (Medical) associated with MT-TS1

01 Dec 2025·Molecular Biology Reports

The first complete mitochondrial genome sequences of the crimson rose (Pachliopta hector) (Papilionidae: Troidini) and phylogenetic analysis

Article

Author: Bhaskar, Ranjana ; Subramanian, Kumarapuram Apadodharanan ; Kanaparthi, Praveen

BACKGROUNDPachliopta hector, known as the crimson rose, is a sizable swallowtail butterfly within the genus Pachliopta (roses) and part of the red-bodied swallowtails group. The mitochondrial genome (mitogenome) offers valuable insights for phylogenetic studies and the evolutionary biology of Pachliopta hector.METHODS AND RESULTSIn this study, we sequenced, characterized, and annotated the mitogenome of P. hector. The complete mitogenome is 15,477 bp long and includes 13 protein-coding genes (PCGs), 22 transfer RNA genes (tRNAs), 2 ribosomal RNA genes (rRNAs), and one control region, all arranged within a single scaffold. The mitogenome exhibits a strong A + T bias of 81.84%, along with a negative AT skew (-0.0379) and a negative GC skew (-0.1989). All PCGs initiate with a standard ATN start codon, while TAA or TAG serves as the common stop codons. Codon usage analysis revealed that the most frequently used amino acids in the mitogenome are Phe, Ile, Leu1, Met, and Asn. Most tRNAs displayed the typical cloverleaf secondary structure, except for trnI, trnS1, and trnF. The loop and DHU stem were absent in trnS1, while both trnF and trnI lacked the TΨC loop. A phylogenetic analysis was performed with 17 other species from the tribe Troidini along with 42 species from tribe Leptocircini, Papilionini, and Teinopalpini, within the subfamily Papilioninae was conducted using Bayesian inference (BI) and maximum likelihood (ML) based on the nucleotide sequences of the 13 mitochondrial PCGs. All the four tribes under Papilioninae were well separated.CONCLUSIONSThe findings suggest that P. hector is a member of the Troidini under subfamily Papilioninae shares sister clade with Pachliopta aristolochiae and Losaria neptunus. The BI and ML tree supported well-defined monophyletic groups at the tribe level and illustrated the relationship between the groups ((Teinopalpini and Papilionini) + Leptocircini) + Troidini)). This research may provide valuable insights into the evolution of P. hector and phylogenetic relationship of tribes Troidini under subfamily Papilioninae.

01 Dec 2025·Genetica

Mitogenomics providing new insights into the phylogenetic structure of subfamily Panchaetothripinae (Thripidae: Terebrantia)

Article

Author: Kumar, Vikas ; Ghosh, Abhishek ; Banerjee, Dhriti ; Tyagi, Kaomud

Complete mitochondrial genome of two species of subfamily Panchaetothripinae, Astrothrips tumiceps (16,467 bp) and Monilothrips kempi (14,773 bp) are generated by Next-Generation Sequencing Method. In this study, the detailed annotation of these mitogenomes as well as comparative analyses are carried out to explore the codon usage, gene composition, and phylogenetic relationship of subfamilies of family Thripidae. Moreover, the gene rearrangement of subfamily Panchaetothripinae of family Thripidae is also studied. Both the mitogenomes featured by 37 genes including 13 PCGs, 22 tRNAs, 2 rRNAs and with single putative control region with a positive AT-skew and negative GC-skew. trnS1 without DHU arm in both species, trnV without DHU arm in M. kempi, and trnE without TΨC loop in As. tumiceps. Further, codon based comparative analysis depicted the existence of natural selection pressure on all the PCGs in all the subfamilies of family Thripidae. The phylogenetic analyses, using the Bayesian inference (BI) and Maximum likelihood (ML) supported the monophyly of two suborders and family Phlaeothripidae. The family Thripidae is recovered as paraphyletic and subfamily Panchaetothripinae is in sister relationship with family Aeolothripidae and Stenurothripidae rather than the other subfamilies of family Thripidae. The gene order of the order Thysanoptera is highly rearranged, while few members of the subfamily Panchaetothripinae showed similar gene order to family Stenurothripidae. Therefore, this study suggests that the phylogenetic relationship between the subfamily Panchaetothripinae and other families is uncertain, necessitating a whole genome-based study to clarify the position of Panchaetothripinae within the suborder Terebrantia.

01 Feb 2025·Biochemical Genetics

Characterization of Complete Mitochondrial Genome of Badri Breed of Bos indicus (Bovidae: Bovinae): Selection Pressure and Comparative Analysis

Article

Author: Bisht, Satpal Singh ; Ghosh, Abhishek ; Arya, Mansi ; Kumar, Vikas ; Tyagi, Kaomud ; Tyagi, Inderjeet

High-altitude mammals are often subject to specific environmental obstacles, which exert selective pressure on their physiological and morphological traits, hence driving their evolutionary processes. It is anticipated that these circumstances will lead to the adaptive evolution of protein-coding genes (PCGs) in the mitochondrial genome, which play a crucial role in the oxidative phosphorylation system. In this study, we have generated the complete mitochondrial genome of the Badri breed of Bos indicus inhabiting a high-altitude environment to test the signatures of adaptive evolution on PCGs and their phylogenetic relationships. The complete mitogenome of the Badri breed is 16,339 bp and most tRNAs showed typical clover-leaf secondary structure with a few exceptions, like trnS1 and trnS2 without DHU arm and trnK without DHU loop. Comparative analysis of PCGs indicated that cox1 is the most conserved, while atp6 is the most variable gene. Moreover, the ratios of non-synonymous to synonymous substitution rates indicated the purifying selection (Ka/Ks < 1) in the protein-coding genes that shape the diversity in mitogenome of Bos indicus. Furthermore, Branch-site model (BSM) suggested that cox1, cox2, nad3, nad4L, and nad6 underwent stronger purifying selection (ω < 1) than other PCGs in 15 breeds of 4 species, including Badri. BSM also detected 10 positive sites in PCGs and one in 13 PCGs concatenated dataset. Additional analyses in Datamonkey indicated 11 positive sites and 23 purifying sites in the concatenated dataset, a relaxation of selection strength in nad3, and no evidence of episodic diversifying selection in any PCGs. Phylogeny revealed the sister relationship of the Badri with other breeds of Bos indicus as well as Bos frontalis (Gayal-2). The mitogenome of the Badri breed is an important genomic resource for conservation genetics of this species and also contributes to the understanding of the adaptive evolution of mitochondrial protein coding genes.

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