Q4 · MEDICINE
Article
Author: Tang, Qiang ; Xiao, Di ; Zhang, Si-Min ; Liu, Rang-Ru ; Xu, Xiao-Jing ; Li, Xi ; Zhou, Hong-Hao ; Zhang, Wei ; Lin, Xu ; Zheng, Yi ; Ji, Li-Nong ; Yin, Ji-Ye ; Gong, Wei-Jing ; Liu, Zhao-Qian ; Han, Xue-Yao
Aim: To investigate the potential genetic effect on metformin efficacy in overweight or obese Chinese Type 2 diabetes mellitus (T2DM) patients. Patients & methods: 768 SNPs in or close to 207 genes were genotyped in 84 patients treated with metformin + glibenclamide/Xiaoke Pill. Significant SNPs were then verified in 107 recent-onset overweight or obese T2DM patients treated with metformin alone. Genotyping was done by Illumina GoldenGate Assay. Results: In the discovery stage, 22 SNPs were nominally significant. IL1B rs1143623 (p = 0.011) and EEF1A1P11-RPL7P9 rs10783050 (p = 0.021) were still significantly associated with the relative change of HbA1cin the replication stage. Conclusion: IL1B rs1143623 and EEF1A1P11-RPL7P9 rs10783050 polymorphisms may contribute to metformin's glucose-lowing efficacy in overweight or obese Chinese T2DM patients.