MIR4686

Last update 08 May 2025

Basic Info

Synonyms

hsa-mir-4686, microRNA 4686, MIR4686

Introduction-

100 Clinical Results associated with MIR4686

100 Translational Medicine associated with MIR4686

0 Patents (Medical) associated with MIR4686

Literatures (Medical) associated with MIR4686

01 Nov 2024·Mini-Reviews in Medicinal Chemistry

ROR1-AS1: A Meaningful Long Noncoding RNA in Oncogenesis

Review

Author: Zhou, Yunxi ; Yuan, Chengfu ; Fan, Hong ; Zhou, Gang ; Zhang, Ziyan

:Long noncoding RNA (lncRNA) is a non-coding RNA with a length of more than 200 nucleotides, involved in multiple regulatory processes in vivo, and is related to the physiology and pathology of human diseases. An increasing number of experimental results suggest that when lncRNA is abnormally expressed, it results in the development of tumors. LncRNAs can be divided into five broad categories: sense, antisense, bidirectional, intronic, and intergenic. Studies have found that some antisense lncRNAs are involved in a variety of human tumorigenesis. The newly identified ROR1-AS1, which functions as an antisense RNA of ROR1, is located in the 1p31.3 region of the human genome. Recent studies have reported that abnormal expression of lncRNA ROR1-AS1 can affect cell growth, proliferation, invasion, and metastasis and increase oncogenesis and tumor spread, indicating lncRNA ROR1-AS1 as a promising target for many tumor biological therapies. In this study, the pathophysiology and molecular mechanism of ROR1-AS1 in various malignancies are discussed by retrieving the related literature.:ROR1-AS1 is a cancer-associated lncRNA, and studies have found that it is either over- or underexpressed in multiple malignancies, including liver cancer, colon cancer, osteosarcoma, glioma, cervical cancer, bladder cancer, lung adenocarcinoma, and mantle cell lymphoma. Furthermore, it has been demonstrated that lncRNA ROR1-AS1 participates in proliferation, migration, invasion, and suppression of apoptosis of cancer cells.:Furthermore, lncRNA ROR1-AS1 promotes the development of tumors by up-regulating or downregulating ROR1-AS1 conjugates and various pathways and miR-504, miR-4686, miR-670-3p, and miR-375 sponges, etc., suggesting that lncRNA ROR1-AS1 may be used as a marker in tumors or a potential therapeutic target for a variety of tumors.

International Journal of NanomedicineQ2 · MEDICINE

<p>Exosomal lncRNA ROR1-AS1 Derived from Tumor Cells Promotes Glioma Progression via Regulating miR-4686</p>

Q2 · MEDICINE

ArticleOA

Author: Xiao, Shun-Wu ; Chai, Yang ; Liang, Chuan-Dong ; You, Chun-Yue ; Xie, Ming-Xiang ; Wu, Hai-Tao

OBJECTIVEGlioma is one of the most common central nervous system malignant tumors, accounting for 45%-60% of adult intracranial tumors. However, the clinical treatment of glioma is limited. It is of great significance to seek new therapeutic methods for glioma via gene therapy.MATERIALS AND METHODSMicroarray is used to identify the lncRNAs that are differentially expressed in glioma. The expression of long non-coding RNA (lncRNA) ROR1-AS1 and miR-4686 was detected by qRT-PCR. Exosomes were isolated from the supernatant of normal and cancerous cells, and TEM was used for exosomes identification. MTT assay, wound healing assay, transwell assay, and colony formation assay were used to detect the exo-ROR1-AS1 function on proliferation, migration, and invasion in glioma cells. Luciferase assay and RIP assay were used to identify the relationship between lncRNA ROR1-AS1 and miR-4686. The effect of exo-ROR1-AS1 on tumorigenesis of glioma was confirmed by the xenograft nude mice model.RESULTSROR1-AS1 was up-regulated in glioma tissues, and the high expression of ROR1-AS1 indicated a poor prognosis in glioma patients. Interestingly, ROR1-AS1 was packaged into exosomes and derived from tumor cells. Functional analysis showed exo-ROR1-AS1 promoted the progression of glioma cell lines SHG44 and U251. Furthermore, ROR1-AS1 acted as a sponge of miR-4686 and inhibited its expression. Functionally, forced expression of miR-4686 removed the promoted effects of lncRNA ROR1-AS1 on glioma development. In vivo tumorigenesis experiments showed that exo-ROR1-AS1 promoted glioma development via miR-4686 axis.CONCLUSIONOur study suggested tumor cells derived exo-ROR1-AS1 promoted glioma progression by inhibiting miR-4686, which might be a potential therapeutic target for glioma clinical treatment.

Nature CommunicationsQ1 · CROSS-FIELD

Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

Q1 · CROSS-FIELD

ArticleOA

Author: Shu, Xiao-Ou ; Kwak, Soo Heon ; Imamura, Minako ; Danesh, John ; Zhao, Wei ; Yasuda, Kazuki ; Kim, Young Jin ; Okada, Yukinori ; Kawamori, Ryuzo ; Tanaka, Yasushi ; Yamauchi, Toshimasa ; Florez, Jose C ; Tam, Claudia H T ; Hirose, Hiroshi ; Frossard, Philippe ; Zheng, Wei ; Burtt, Noël P ; Iwata, Minoru ; Jørgensen, Torben ; Moon, Sanghoon ; Cho, Yoon Shin ; Brandslund, Ivan ; Pedersen, Oluf ; Tusié-Luna, Teresa ; Wang, Xu ; Maegawa, Hiroshi ; Kubo, Michiaki ; Tai, E Shyong ; Long, Jirong ; Moreno-Macías, Hortensia ; Huerta-Chagoya, Alicia ; Tobe, Kazuyuki ; Kim, Bong-Jo ; Watada, Hirotaka ; Jørgensen, Marit E ; Fujita, Hayato ; Jia, Weiping ; Iwasaki, Minaka ; Ma, Ronald C W ; Hosoe, Jun ; Singh, Jai Rup ; Maeda, Shiro ; Hara, Kazuo ; Saleheen, Danish ; Saxena, Richa ; Ito, Chikako ; Hu, Cheng ; Suzuki, Ken ; Witte, Daniel R ; Zhang, Rong ; Sanghera, Dharambir ; Christensen, Cramer ; Park, Kyong Soo ; Rasheed, Asif ; Shojima, Nobuhiro ; Kaku, Kohei ; Grarup, Niels ; Flannick, Jason ; Chan, Juliana C N ; Kadowaki, Takashi ; Mercader, Josep M ; Hansen, Torben ; Takahashi, Atsushi

AbstractGenome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10−8), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.

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MIR4686

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