H1-8

Last update 08 May 2025

Basic Info

Synonyms

H1-8, H1.8 linker histone, H1FOO

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Introduction

May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity).

100 Clinical Results associated with H1-8

100 Translational Medicine associated with H1-8

0 Patents (Medical) associated with H1-8

118

Literatures (Medical) associated with H1-8

01 Jan 2025·Plant Science

Mutation of rice SM1 enhances solid leaf midrib formation and increases methane emissions

Article

Author: Huang, Xianzhong ; Cheng, Weimin ; Fang, Cheng ; Wu, Kun ; Jiang, Hongrui ; Chen, Chunpeng ; Fu, Xiangdong ; Zhan, Yue ; Liu, Binmei ; Wu, Yuejin ; Tao, Liangzhi ; Ye, Yafeng ; Yang, Yang

The leaf midrib system is essential for plant growth and development, facilitating nutrient transport, providing structural support, enabling gas exchange, and enhancing resilience to environmental stresses. However, the molecular mechanism regulating leaf midrib development is still unclear.In this study, we reported a rice solid midrib 1 (sm1) mutant, exhibiting solid leaf aerenchyma and abaxial rolling leaves due to abnormal development of parenchyma and bulliform cells. Map-based cloning revealed that SM1 encodes a litter zipper protein (ZPR). SM1 was mainly expressed in the sheaths and basal midrib and was associated with the nucleus. Further experiments indicated that SM1 can interact with OSHB1, preventing the formation of OSHB:OSHB dimers and subsequently repressing the expression of OSH1 involved in the regulation and maintenance of apical stem meristem formation. The sm1 mutant reduced long-distance oxygen transport ability from shoot to root. The impaired oxygen transport in the sm1 mutant may have contributed to the increase in methanogens and elevated methane emissions. Collectively, our findings revealed that the SM1-OSHB1-OSH1 modules regulate leaf aerenchyma development in rice. These modules not only enhance our understanding of the molecular mechanism of rice leaf aerenchyma development but also offer insights for reducing methane emissions through genetic modification.

01 Jan 2025·Methods in Molecular Biology

Purification of Anti-OSH1 IgG and Immunohistochemical Staining of Rice Shoot Apical Meristem

Article

Author: Sato, Yutaka ; Nosaka-Takahashi, Misuzu ; Yoshikawa, Takanori ; Tezuka, Takumi

Immunohistochemical staining (IHC) enables the visualization of protein localization within tissues and organs. Here, we describe IHC to detect the ORYZA SATIVA HOMEOBOX1 (OSH1) protein in sections of rice shoot apical meristems (SAMs). First, anti-OSH1 IgG is purified from OSH1 polyclonal rabbit antisera. For subsequent IHC, rice shoot apices are fixed and embedded in paraffin and sections are prepared for IHC. In this IHC procedure, two different labeling methods, fluorescein isothiocyanate and alkaline phosphatase, are utilized for secondary antibody detection.

01 Dec 2024·Planta

SUMOylation of rice DELLA SLR1 modulates transcriptional responses and improves yield under salt stress

Article

Author: Abreu, Isabel A. ; Rodrigues, Mafalda A. A. ; Oliveira, M. Margarida ; Barros, Pedro M. ; Gonçalves, Nuno M. ; Matiolli, Cleverson C ; Fernandes, Telma ; Rodrigues, Mafalda A A ; Oliveira, M Margarida ; Barros, Pedro M ; Matiolli, Cleverson C. ; Gonçalves, Nuno M ; Abreu, Isabel A

AbstractMain conclusionSUMOylation of SLR1 at K2 protects productivity under salt stress, possibly by modulation of SLR1 interactome.AbstractDELLA proteins modulate GA signaling and are major regulators of plant plasticity to endure stress. DELLAs are mostly regulated at the post-translational level, and their activity relies on the interaction with upstream regulators and transcription factors (TFs). SUMOylation is a post-translational modification (PTM) capable of changing protein interaction and has been found to influence DELLA activity in Arabidopsis. We determined that SUMOylation of the single rice DELLA, SLENDER RICE1 (SLR1), occurs in a lysine residue different from the one identified in Arabidopsis REPRESSOR OF GA (RGA). Artificially increasing the SUMOylated SLR1 levels attenuated the penalty of salt stress on rice yield. Gene expression analysis revealed that the overexpression of SUMOylated SLR1 can regulate GA biosynthesis, which could partially explain the sustained productivity upon salt stress imposition. Furthermore, SLR1 SUMOylation blocked the interaction with the growth regulator YAB4, which may fine-tune GA20ox2 expression. We also identified novel SLR1 interactors: bZIP23, bHLH089, bHLH094, and OSH1. All those interactions were impaired in the presence of SUMOylated SLR1. Mechanistically, we propose that SUMOylation of SLR1 disrupts its interaction with several transcription factors implicated in GA-dependent growth and ABA-dependent salinity tolerance to modulate downstream gene expression. We found that SLR1 SUMOylation represents a novel mechanism modulating DELLA activity, which attenuates the impact of stress on plant performance.

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H1-8

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