CFAP77

Last update 08 May 2025

Basic Info

Synonyms

C9orf171, CFAP77, cilia and flagella associated protein 77

+ [2]

Introduction

Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.

100 Clinical Results associated with CFAP77

100 Translational Medicine associated with CFAP77

0 Patents (Medical) associated with CFAP77

Literatures (Medical) associated with CFAP77

15 Apr 2023·Nature communicationsQ1 · CROSS-FIELD

Native doublet microtubules from Tetrahymena thermophila reveal the importance of outer junction proteins.

Q1 · CROSS-FIELD

ArticleOA

Author: Bui, Khanh Huy ; Kubo, Shintaroh ; Joachimiak, Ewa ; Valente-Paterno, Melissa ; Fan, Zhe ; Black, Corbin S ; Legal, Thibault ; Yang, Shun Kai ; Marcotte, Edward M ; Peri, Katya ; Khalifa, Ahmad Abdelzaher Zaki ; Huynh, Phuong M ; McCafferty, Caitlyn L ; De Bellis, Chelsea ; Wloga, Dorota ; Ghanaeian, Avrin

Cilia are ubiquitous eukaryotic organelles responsible for cellular motility and sensory functions. The ciliary axoneme is a microtubule-based cytoskeleton consisting of two central singlets and nine outer doublet microtubules. Cryo-electron microscopy-based studies have revealed a complex network inside the lumen of both tubules composed of microtubule-inner proteins (MIPs). However, the functions of most MIPs remain unknown. Here, we present single-particle cryo-EM-based analyses of the Tetrahymena thermophila native doublet microtubule and identify 42 MIPs. These data shed light on the evolutionarily conserved and diversified roles of MIPs. In addition, we identified MIPs potentially responsible for the assembly and stability of the doublet outer junction. Knockout of the evolutionarily conserved outer junction component CFAP77 moderately diminishes Tetrahymena swimming speed and beat frequency, indicating the important role of CFAP77 and outer junction stability in cilia beating generation and/or regulation.

01 Jan 2023·Journal of Dairy Science

Estimation of genetic parameters and single-step genome-wide association studies for milk urea nitrogen in Holstein cattle

Article

Author: Wang, Yachun ; Wang, Lei ; Ma, Longgang ; Guo, Gang ; Chen, Ziwei ; Luo, Hanpeng ; Brito, Luiz F ; Zhang, Fan ; Chang, Yao ; Lou, Wenqi

The main objectives of this study were to estimate genetic parameters for milk urea nitrogen (MUN) in Holstein cattle and to conduct a single-step (ss)GWAS to identify candidate genes associated with MUN. Phenotypic measurements from 24,435 Holstein cows were collected from March 2013 to July 2019 in 9 dairy farms located in the Beijing area, China. A total of 2,029 cows were genotyped using the Illumina 150K Bovine Bead Chip, containing 121,188 SNP. A single-trait repeatability model was used to evaluate the genetic background of MUN. We found that MUN is a trait with low heritability (0.06 ± 0.004) and repeatability (0.12). Considering similar milk production levels, a lower MUN concentration indicates higher nitrogen digestibility. The genetic correlations between MUN and milk yield, net energy concentration, fat percentage, protein percentage, and lactose percentage were positive and ranged from 0.02 to 0.26. The genetic correlation between MUN and somatic cell score (SCS) was negative (-0.18), indicating that animals with higher MUN levels tend to have lower SCS. Both ssGWAS and pathway enrichment analyses were used to explore the genetic mechanisms underlying MUN. A total of 18 SNP (located on BTA11, BTA12, BTA14, BTA17, and BTA18) were found to be significantly associated with MUN. The genes CFAP77, CAMSAP1, CACNA1B, ADGRB1, FARP1, and INTU are considered to be candidate genes for MUN. These candidate genes are associated with important biological processes such as protein and lipid metabolism and binding to specific proteins. This set of candidate genes, metabolic pathways, and their functions provide a better understanding of the genomic architecture and physiological mechanisms underlying MUN in Holstein cattle.

Scientific Reports

Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American Women

Article

Author: Gelernter, Joel ; Cheng, Zhongshan ; Kranzler, Henry R ; Zhang, Huiping ; Montalvo-Ortiz, Janitza L

AbstractThere is currently an epidemic of opioid use, overdose, and dependence in the United States. Although opioid dependence (OD) is more prevalent in men, opioid relapse and fatal opioid overdoses have recently increased at a higher rate among women. Epigenetic mechanisms have been implicated in the etiology of OD, though most studies to date have used candidate gene approaches. We conducted the first epigenome-wide association study (EWAS) of OD in a sample of 220 European-American (EA) women (140 OD cases, 80 opioid-exposed controls). DNA was derived from whole blood samples and EWAS was implemented using the Illumina Infinium HumanMethylationEPIC array. To identify differentially methylated CpG sites, we performed an association analysis adjusting for age, estimates of cell proportions, smoking status, and the first three principal components to correct for population stratification. After correction for multiple testing, association analysis identified three genome-wide significant differentially methylated CpG sites mapping to the PARG, RERE, and CFAP77 genes. These genes are involved in chromatin remodeling, DNA binding, cell survival, and cell projection. Previous genome-wide association studies have identified RERE risk variants in association with psychiatric disorders and educational attainment. DNA methylation age in the peripheral blood did not differ between OD subjects and opioid-exposed controls. Our findings implicate epigenetic mechanisms in OD and, if replicated, identify possible novel peripheral biomarkers of OD that could inform the prevention and treatment of the disorder.

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CFAP77

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