MIR4521

Last update 08 May 2025

Basic Info

Synonyms

hsa-mir-4521, microRNA 4521, MIR4521

Introduction-

100 Clinical Results associated with MIR4521

100 Translational Medicine associated with MIR4521

0 Patents (Medical) associated with MIR4521

Literatures (Medical) associated with MIR4521

31 Dec 2024·Bioengineered

Statement of Retraction: MicroRNA-4521 targets hepatoma up-regulated protein (HURP) to inhibit the malignant progression of breast cancer

31 Dec 2024·BioengineeredQ4 · BIOLOGY

MicroRNA-4521 targets hepatoma up-regulated protein (HURP) to inhibit the malignant progression of breast cancer

Q4 · BIOLOGY

ArticleOA

Author: Peng, Sen ; Li, Changwen ; Tang, Chuangang

Changwen Li, Sen Pengb, and Chuangang Tanga. MicroRNA-4521 targets hepatoma up-regulated protein (HURP) to inhibit the malignant progression of breast cancer. Bioengineered. 2021 Oct. doi: 10.1080/21655979.2021.1996016.Since publication, significant concerns have been raised about the compliance with ethical policies for human research and the integrity of the data reported in the article.When approached for an explanation, the authors provided some original data but were not able to provide all the necessary supporting information. As verifying the validity of published work is core to the scholarly record's integrity, we are retracting the article. All authors listed in this publication have been informed.We have been informed in our decision-making by our editorial policies and the COPE guidelines.The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as 'Retracted.'

01 Jun 2024·Experimental Dermatology

miR‐4521—A novel biomarker for human lentigos

Article

Author: Chumsakul, Onuma ; Funakoshi, Ayaka ; Suzuki‐Horiuchi, Yoko ; Sato, Yasunari ; Maeno, Hiroshi ; Ishii, Tsuyoshi ; Seykora, John T.

A review.This study investigates the role of microRNA-4521 (miR-4521) as a novel biomarker for human lentigos, a common benign skin lesion characterized by localized hyperpigmentation.Through a comprehensive anal. of skin biopsies from patients with lentigos and healthy controls, we identified significantly elevated levels of miR-4521 expression in lentigo lesions compared to normal skin.Functional assays demonstrated that miR-4521 modulates key cellular pathways associated with melanogenesis and cell proliferation, suggesting its involvement in the pathophysiol. of lentigo development.Addnl., our results indicate that miR-4521 may serve as a potential diagnostic marker, as its expression levels correlated with the clin. severity of the lesions.In silico anal. revealed potential target genes of miR-4521 that are involved in pigmentation regulation, supporting its role in melanocyte function.This study highlights miR-4521 as a promising biomarker for lentigos and provides insight into the mol. mechanisms underlying their formation, paving the way for future research into targeted therapies and early diagnostic strategies for pigmented skin lesions.

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MIR4521

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