SPDEF

Last update 08 May 2025

Basic Info

Synonyms

bA375E1.3, PDEF, Prostate epithelium-specific Ets transcription factor

+ [6]

Introduction

May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter.

100 Clinical Results associated with SPDEF

100 Translational Medicine associated with SPDEF

0 Patents (Medical) associated with SPDEF

664

Literatures (Medical) associated with SPDEF

01 Jun 2025·Fish & Shellfish Immunology

The defatted black soldier fly meal (Hermetia illucens) improved the pathogen resistance and gut health of Nile Tilapia (Oreochromis niloticus)

Article

Author: Bao, Ming-Yang ; Wang, Tong ; Wang, Zhe ; Qiao, Fang ; Wei, Hua ; Zhou, Nan-Nan ; Xiao, Guan-Xiu ; Zhang, Mei-Ling ; Du, Zhen-Yu

As a novel protein source, the black soldier fly (Hermetia illucens) possesses the potential to enhance fish health due to its high protein content, essential amino acids, and bioactive compounds, but the mechanisms by which defatted black soldier fly meal affects fish health remain unclear. This study aimed to evaluate the effects of partially replacing soybean meal (SM) with defatted black soldier fly larvae meal on the pathogen resistance of juvenile Nile tilapia (Oreochromis niloticus) and to explore the underlying mechanisms. Defatted black soldier fly (Hermetia illucens) meal was used to replace 0 % (CON), 15 % (H15), 30 % (H30), 45 % (H45), and 60 % (H60) of soybean meal in the diets, which were fed to Nile tilapia for 8 weeks. At the second week of the experiment, an unexpected infection was observed in the Nile tilapia, with subsequent isolation and identification confirming the pathogen as Aeromonas veronii. The results showed that defatted black soldier fly meal improved the survival rate and reduced the intestinal inflammation of Nile tilapia in H60 group compared to CON group (P < 0.05). Periodic acid-Schiff (PAS) staining of the gut indicated that a 60 % replacement of soybean meal with defatted black soldier fly meal significantly increased the number of goblet cells in the intestine (P < 0.05) and upregulated the expression level of mucin 2 (muc2) (P < 0.05). Throughout the experiment period, the survival rate in the defatted black soldier fly meal groups was higher than that in the soybean meal group, with the H60 group exhibiting the most significant improvement. In addition, defatted black soldier fly meal exhibited a promotion effect on goblet cell numbers, mucin production and mucin secretion with a dose dependent manner (P < 0.05). To identify the possible mechanism by which defatted black soldier fly meal enhanced goblet cell numbers, gut microbiome and metabolomics were conducted. The results showed that the defatted black soldier fly meal altered the composition of intestinal microbiota and increased the content of L-tyrosine in the H60 group. The effects of L-tyrosine were further identified in LS174T cells, and the results showed that L-tyrosine upregulated the expression levels of muc2 and SAM pointed domain-containing Ets transcription factor (spdef) (P < 0.05). In conclusion, the defatted black soldier fly meal improves gut health and enhances pathogen resistance, ultimately leading to the increased survival rates of Nile tilapia when exposed to A. veronii.

01 May 2025·Journal of Adolescent Health

Childhood Adversity and Civic Engagement During Emerging Adulthood

Article

Author: Johnson, Sara B ; Sosnowski, David W ; Klein, Lauren M ; Duke, Naomi N

PURPOSEChildhood adversity is linked to poorer adult health; prior research has established a reciprocal association between health and civic engagement. However, little research has examined the relationship between adverse childhood experiences (ACEs) and civic engagement. We examined whether ACEs are associated with civic engagement at ages 18-26 years and evaluated the potential moderating role of perceived survival expectations (PSE) (i.e., likelihood of living to age 35).METHODSData are from Waves I, III, and IV of the National Longitudinal Study of Adolescent to Adult Health. Multivariable linear regression using survey weights was used to model associations between experiencing 0, 1, 2-3, or 4+ ACEs and civic engagement (composite score) overall and by type of ACE (i.e., child maltreatment, violent victimization in the community, family member suicide, family substance abuse, divorce, household member incarceration, and family member death). An ACE by PSE interaction term was tested.RESULTSTwelve thousand two hundred eighty eight participants were included. Experiencing 2-3 ACEs (β = -0.14; confidence interval [CI]: -0.23, -0.043) and 4+ ACEs (β = -0.17; CI: -0.32, -0.025) were each associated with lower civic engagement compared to experiencing no ACEs. Violent victimization (β = -0.14; CI: -0.22, -0.058) and family substance abuse (β = -0.13; CI: -0.21, -0.049) were negatively associated with civic engagement, accounting for multiple comparisons. There was no evidence of moderation by PSE.DISCUSSIONACEs, particularly violent victimization in the community and family substance abuse, may shape civic development. Interventions could promote civic engagement and lessen the impact of childhood adversity on individual and community health.

01 Mar 2025·Mucosal Immunology

Gut microbiota regulates intestinal goblet cell response and mucin production by influencing the TLR2-SPDEF axis in an enteric parasitic infection

Article

Author: Haq, Sabah ; Seto, Tyler ; Khan, Waliul I ; Grondin, Jensine A ; Haider, Zarin ; Yousefi, Yeganeh ; Wang, Huaqing ; Banskota, Suhrid ; Surette, Michael

Alterations in goblet cell biology constitute one of the most effective host responses against enteric parasites. In the gastrointestinal (GI) tract, millions of bacteria influence these goblet cell responses by binding to pattern recognition receptors such as toll-like receptors (TLRs). Studies suggest that the gut microbiota also interacts bidirectionally with enteric parasites, including Trichuris muris. Here, we study the roles of T. muris-altered microbiota and the TLR2-SPDEF axis in parasitic host defense. In acute T. muris infection, we observed altered gut microbiota composition, which, when transferred to germ-free mice, resulted in increased goblet cell numbers, Th2 cytokines and Muc2 expression, as well as increased Tlr2. Further, antibiotic (ABX)-treated TLR2^-/- mice, despite having received the same T. muris-altered microbiota, displayed diminished Th2 response, Muc2 expression, and, intriguingly, diminished SPDEF expression compared to wildtype counterparts. When infected with T. muris, SPDEF^-/- mice exhibited a reduced Th2 response and altered microbial composition compared to SPDEF^+/+, particularly on day 14 post-infection, and this microbiota was sufficient to alter host goblet cell response when transferred to ABX-treated mice. Taken together, our findings suggest the TLR2-SPDEF axis, via T. muris-induced microbial changes, is an important regulator of goblet cell function and host's parasitic defense.

Analysis

Perform a panoramic analysis of this field.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

SPDEF

Basic Info

Related

Analysis