PDLIM1

Last update 08 May 2025

Basic Info

Synonyms

C-terminal LIM domain protein 1, CLIM1, CLP-36

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Introduction

Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity).

100 Clinical Results associated with PDLIM1

100 Translational Medicine associated with PDLIM1

0 Patents (Medical) associated with PDLIM1

149

Literatures (Medical) associated with PDLIM1

01 May 2025·Experimental Eye Research

Integration of single-cell and bulk transcriptomics reveals β-hydroxybutyrylation-related signatures in primary open-angle glaucoma

Article

Author: Wang, Aiqin ; Fan, Yuchen ; Li, Juan ; Li, Ning ; Dai, Qing ; Gao, Ziqing ; Zhao, Sijie

The pathophysiology of primary open-angle glaucoma (POAG), the most prevalent glaucoma type, is poorly understood. Although it is well known that epigenetic factors affect the progression of POAG, the impact of β-hydroxybutyrylation (Kbhb) on POAG remains unknown. Based on POAG-related datasets (GSE27276, GSE4316, and GSE231749) retrieved from the Gene Expression Omnibus (GEO) database, four biomarkers (FABP5, GLS, PDLIM1, and TAGLN) with a diagnostic value for POAG were identified by combining differential expression analysis, machine learning algorithms, and receiver operating characteristic (ROC) analysis. Immune infiltration analysis demonstrated significant differences in the infiltration abundances of 10 immune cells between POAG and controls, including regulatory T cells, monocytes, and macrophages, with notable positive correlations between TAGLN expression and these immune cells. Subsequently, single-cell analysis revealed that GLS, PDLIM1, and TAGLN were higher expressed in chondrocytes, smooth muscle cells, and endothelial cells. In addition, in vitro cellular experiments and animal models revealed that the TAGLN expression trend was consistent with the data from GSE27276 and GSE4316. In conclusion, TAGLN may play an important role in understanding of the molecular mechanisms of POAG and exploration of therapeutic targets.

01 Apr 2025·Autonomic Neuroscience

Quantitative serum proteomic analysis for biomarker discovery in post-COVID-19 postural orthostatic tachycardia syndrome (PC-POTS) patients

Article

Author: Hoke, Ahmet ; Chung, Tae ; Jeong, Seeun Judy ; Ryu, Taekyung ; Adler, Brittany L ; Na, Chan Hyun ; Lee, David C

Postural orthostatic tachycardia syndrome (POTS) is a chronic, debilitating condition that is characterized by an excessive increase in heart rate upon orthostatic challenge. Before the COVID-19 pandemic, POTS affected 0.5 % to 1 % of the U.S. population. Since the pandemic, the incidence has risen sharply, adding an estimated 6-7 million new cases in the U.S. Despite its importance, there is currently no reliable biomarker for POTS, leading to significant diagnostic delays. A major hurdle in identifying biomarkers is the heterogeneous nature of the syndrome. To address this, we focused on a homogeneous subgroup of post-COVID-19 POTS (PC-POTS) patients. We conducted quantitative proteomics on sera from 9 PC-POTS patients and 9 healthy controls, identifying 31 proteins with significantly different abundances in PC-POTS patients. Most elevated proteins were linked to actin filaments or immune functions/inflammation. Weighted Gene Co-Expression Network Analysis revealed module 7 (M7) correlated strongly with PC-POTS diagnosis and related traits. The key proteins in M7 included MTPN, TAGLN2, ADP-ribosylation factor 1, PDLIM1, PPIA, CNN2, LGALSL, TXN, TLN1, TUBA4A, IL4, TREML1, GP1BA, and, all highly correlated with these traits. Cell-type enrichment analysis revealed that M7 was highly associated with immune and neuronal cells. The main pathways identified in M7 included the integrin signaling pathway, blood coagulation, and glycolysis. These findings suggest that the key proteins in M7 could serve as biomarkers for PC-POTS. This study uses quantitative proteomics to identify potential biomarkers that differentiate PC-POTS patients from healthy controls, establishing a foundation for further research and validation.

31 Mar 2025·The FASEB Journal

PDLIM1 suppresses retinal neovascularization by regulating the β‐catenin pathway

Article

Author: Du, Yunhui ; Feng, Wen ; Xie, Pinxue ; Gao, Xinxiao ; Duan, Yanru

AbstractRetinal neovascularization (RNV) is an important pathological change associated with proliferative diabetic retinopathy (PDR), which is a common cause of vision loss. PDZ and LIM domain protein 1 (PDLIM1) plays an important role in the occurrence and development of nonproliferative diabetic retinopathy (NPDR); however, the role of PDLIM1 in PDR remains unclear. We conducted gain‐of‐function studies using adenovirus infection and found that PDLIM1 overexpression inhibited the migration, proliferation, and tube formation of vascular endothelial cells. Moreover, PDLIM1 regulated the expression of β‐catenin in vascular endothelial cells. Furthermore, in an oxygen‐induced retinopathy model, PDLIM1 negatively regulated β‐catenin, and the inhibition of PDLIM1 promoted RNV. In contrast, increased PDLIM1 levels significantly inhibited the formation of RNV. In summary, our findings provide evidence that PDLIM1 plays an important role in pathological neovascularization and may serve as a target for the treatment of RNV.

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PDLIM1

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