TMED7

Last update 08 May 2025

Basic Info

Synonyms

CGI-109, FLJ90481, p24 family protein gamma-3

+ [6]

Introduction

Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications.

100 Clinical Results associated with TMED7

100 Translational Medicine associated with TMED7

0 Patents (Medical) associated with TMED7

Literatures (Medical) associated with TMED7

01 Feb 2025·Animal Genetics

Several variants on chromosome 10 are associated with coarse hair diameter in Dazu black goats (Capra hircus)

Article

Author: Xu, Jiele ; Zhang, Jipan ; Fang, Jiabei ; Zhang, Siyuan ; Zhao, Yongju

AbstractGoats typically have double coats, with the outermost coarse hairs providing protection against mechanical and radiation damage. While much attention has been paid to cashmere due to its status as a high‐end textile material, there is limited information available on coarse hair. This study aimed to identify genomic variants, such as single nucleotide polymorphisms (SNPs) and insertion/deletions (indels), associated with coarse hair diameter using a genome‐wide association study (GWAS). Coarse hairs and blood samples were collected from 263 adult female goats. The diameter of coarse hairs was measured using an inverted microscope, and whole genome sequencing was conducted on the blood samples. After reads mapping, variants calling, and quality control, totals of 11 322 006 SNPs and 863 734 indels were included for SNP‐GWAS and indel‐GWAS analyses. Eight significant SNPs (p < 8.98e‐8) and three significant indels (p < 1.16e‐6) were identified. Among those, one SNP was located on Chromosome 4 and near the genes COL28A1 and C1GALT1. Seven significant SNPs were found in the region chr10_96664101–96670958, with the genes CDO1 and TMED7 located upstream and downstream, respectively. Haplotype analysis revealed that the diverse haplotypes of these seven SNPs presented varying values for coarse hair diameter. Notably, the only consistently significant insertion (chr10_96665085, GTA>G) was also located within the region chr10_96664101–96670958, further highlighting the importance of this genomic region in influencing coarse hair diameter. These significant variants and genomic regions provide valuable insights for investigating the genetic mechanisms underlying the variation in fiber diameter.

01 Nov 2023·Traffic (Copenhagen, Denmark)

Anterograde trafficking of Toll-like receptors requires the cargo sorting adaptors TMED-2 and 7.

Article

Author: Soares, Sandro G ; Gay, Nicholas J ; Symmons, Martyn F ; Holm, Julia E J ; Huddin, Afiqah Saleh ; Moncrieffe, Martin C

Toll-Like Receptors (TLRs) play a pivotal role in immunity by recognising conserved structural features of pathogens and initiating the innate immune response. TLR signalling is subject to complex regulation that remains poorly understood. Here we show that two small type I transmembrane receptors, TMED2 and 7, that function as cargo sorting adaptors in the early secretory pathway are required for transport of TLRs from the ER to Golgi. Protein interaction studies reveal that TMED7 interacts with TLR2, TLR4 and TLR5 but not with TLR3 and TLR9. On the other hand, TMED2 interacts with TLR2, TLR4 and TLR3. Dominant negative forms of TMED7 suppress the export of cell surface TLRs from the ER to the Golgi. By contrast TMED2 is required for the ER-export of both plasma membrane and endosomal TLRs. Together, these findings suggest that association of TMED2 and TMED7 with TLRs facilitates anterograde transport from the ER to the Golgi.

01 Dec 2020·Journal of Cell ScienceQ2 · BIOLOGY

AGS3-dependent trans-Golgi network membrane trafficking is essential for compaction in mouse embryos

Q2 · BIOLOGY

Article

Author: Zhou, Wenjun ; Zhou, Dong-Jie ; Niu, Ying-Jie ; Cui, Xiang-Shun ; Nie, Zheng-Wen ; Kim, Ju-Yeon

ABSTRACTActivator of G-protein signaling 3 (AGS3, also known as GPSM1) regulates the trans-Golgi network. The AGS3 GoLoco motif binds to Gαi and thereby regulates the transport of proteins to the plasma membrane. Compaction of early embryos is based on the accumulation of E-cadherin (Cdh1) at cell-contacted membranes. However, how AGS3 regulates the transport of Cdh1 to the plasma membrane remains undetermined. To investigate this, AGS3 was knocked out using the Cas9-sgRNA system. Both trans-Golgi network protein 46 (TGN46, also known as TGOLN2) and transmembrane p24-trafficking protein 7 (TMED7) were tracked in early mouse embryos by tagging these proteins with a fluorescent protein label. We observed that the majority of the AGS3-edited embryos were developmentally arrested and were fragmented after the four-cell stage, exhibiting decreased accumulation of Cdh1 at the membrane. The trans-Golgi network and TMED7-positive vesicles were also dispersed and were not polarized near the membrane. Additionally, increased Gαi1 (encoded by GNAI1) expression could rescue AGS3-overexpressed embryos. In conclusion, AGS3 reinforces the dynamics of the trans-Golgi network and the transport of TMED7-positive cargo containing Cdh1 to the cell-contact surface during early mouse embryo development.

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TMED7

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