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Author: Beilby, John ; Bossé, Yohan ; Grallert, Harald ; Enroth, Stefan ; Musk, Arthur W ; Shrine, Nick ; Lopez, Lorna M ; Gieger, Christian ; Karrasch, Stefan ; Zhao, Jing Hua ; Stubbe, Beate ; Rawal, Rajesh ; Wilson, James F ; Wain, Louise V ; Lind, Lars ; Polasek, Ozren ; Miller, Suzanne ; Nickle, David C ; Obeidat, Ma'en ; Imboden, Medea ; Schulz, Holger ; Kumar, Ashish ; Hartikainen, Anna-Liisa ; Gläser, Sven ; Ripatti, Samuli ; Kolcic, Ivana ; Sayers, Ian ; Tobin, Martin D ; Ingelsson, Erik ; McArdle, Wendy L ; Padmanabhan, Sandosh ; Völzke, Henry ; Morris, Andrew P ; Marten, Jonathan ; Wareham, Nicholas J ; Albrecht, Eva ; Ntalla, Ioanna ; Kheirallah, Abdul Kader ; Starr, John M ; Navarro, Pau ; Hayward, Caroline ; Kähönen, Mika ; Jarvis, Deborah L ; Granell, Raquel ; Heinrich, Joachim ; Brandsma, Corry-Anke ; Gyllensten, Ulf ; Horikoshi, Momoko ; Vitart, Veronique ; Deary, Ian J ; Wright, Alan F ; James, Alan L ; Wild, Sarah H ; Jarvelin, Marjo-Riitta ; Johansson, Åsa ; Hocking, Lynne ; Lehtimäki, Terho ; Mahajan, Anubha ; Hysi, Pirro G ; Rudan, Igor ; Heliövaara, Markku ; Hui, Jennie ; Evans, David M ; Zemunik, Tatijana ; Teumer, Alexander ; Trochet, Holly ; Melén, Erik ; Campbell, Harry ; Viñuela, Ana ; Strachan, David P ; Huffman, Jennifer E ; Probst-Hensch, Nicole M ; Spector, Tim D ; Henderson, John ; Sin, Don D ; Hutri-Kähönen, Nina ; Alves, Alexessander Couto ; Lyytikäinen, Leo-Pekka ; Raitakari, Olli T ; Soler Artigas, María ; González, Juan R ; Scott, Robert A ; Ried, Janina S ; Hall, Ian P ; Surakka, Ida ; Hammond, Chris J ; Joshi, Peter K ; Harris, Sarah E ; Flexeder, Claudia ; Kemp, John P
AbstractLung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10−8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
