SNHG20

Last update 08 May 2025

Basic Info

Synonyms

C17orf86, DKFZp686L05235, FLJ25582

+ [6]

Introduction-

100 Clinical Results associated with SNHG20

100 Translational Medicine associated with SNHG20

0 Patents (Medical) associated with SNHG20

Literatures (Medical) associated with SNHG20

01 Mar 2025·Asian Pacific Journal of Cancer Prevention

Role of SNHGs in Adverse Prognostic Factors in Cervical Cancer: A Systematic Review

Review

Author: Oliveira, Ana Gabriela Caldas ; Lima, Fernanda Jeniffer Lindoso ; Silva, Jessica Manoelli Costa Da ; Matos, Ana Gabrielly De Melo ; Cartagenes, Maria Do Socorro De Sousa ; Araujo, Eleilde Almeida ; Pinho, Jaqueline Diniz ; Silva, Gyl Eanes Barros ; Khayat, André Salim ; Andrade, Marcelo Souza De ; Moreira, Fabiano Cordeiro

OBJECTIVEThis study aims to summarize the main findings in the literature regarding the family of long non-coding RNAs (LncRNAs), specifically SNHGs, in cervical cancer.METHODSThe study was conducted following the PRISMA protocol, using the PICOS framework for the search strategy. The research sources included PubMed, ScienceDirect, Lilacs, and Medline. Inclusion and exclusion criteria were applied, and data from each article were extracted, including: clinicopathological characteristics, biological function of SNHGs, clinical indicators, and diagnostic and prognostic markers.RESULTSOut of a total of 3.803 studies, 12 were selected, encompassing 8 SNHGs (GAS5, SNHG5, SNHG7, SNHG12, SNHG14, SNHG16, SNHG17, and SNHG20) associated with cervical cancer. All, except for GAS5, showed increased expression. In the literature review, SNHG expression was linked to adverse prognostic factors in cervical cancer, such as proliferation, migration, invasion, lymph node metastasis, and apoptosis.CONCLUSIONAlthough further studies are needed, these data highlight the significant role of SNHGs in tumor biology and the promising potential of this class of transcripts as tools in the clinical management of cervical cancer.

18 Feb 2025·Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

[Effects of LncRNA SNHG20 on epithelial mesenchymal transition and microtubule formation in human oral squamous cell carcinoma cells through targeted regulation of the miR-520c-3p/RAB22A pathway].

Article

Author: Zhao, Yang ; Chao, Xiaoqin ; Zhao, Guoting ; Ma, Minying

OBJECTIVETo investigate the effects of LncRNA SNHG20 on epithelial mesenchymal transition (EMT) and microtubule formation in human oral squamous cell carcinoma (OSCC) cells through targeted regulation of the miR-520c-3p/RAB22A pathway.METHODSAfter real-time fluorescence quantitative detection of LncRNA SNHG20, miR-520c-3p, RAB22A mRNA expression levels in OSCC tissues and cells, dual luciferase reporter assay was used to detect the relationship between the three. OSCC cells were randomly separated into control group, sh-NC group, sh-SNHG20 group, sh-SNHG20+anti NC group, and sh-SNHG20+anti miR-520c-3p group. Western blotting was used to detect the expression of N-cadherin, vimentin, and E-cadherin proteins in the OSCC cells. The morphology of HSC-3 cells was observed under microscope. Changes in the number of microtubules formed were detected. The effect of LncRNA SNHG20 on the growth of OSCC tumors and the expression levels of LncRNA SNHG20, miR-520c-3p and RAB22 A in the transplanted tumors were detected by nude mice tumorigenesis experiment.RESULTSLncRNA SNHG20 and RAB22A mRNA were upregulated in the OSCC tissues and cells, while miR-520c-3p was downregulated (P < 0.05). There were binding sites between LncRNA SNHG20 and miR-520c-3p, RAB22A and miR-520c-3p, which had targeted regulation relationship. Compared with the sh-NC group, the sh-SNHG20 group had fewer stromal like cells, more epithelial like cells, incomplete microtubule structure, and fewer nodules. LncRNA SNHG20, RAB22A, N-Cadherin, and vimentin were downregulated, while miR-520c-3p and E-cadherin were upregulated (P < 0.05). Compared with the sh-SNHG20+anti-NC group, the sh-SNHG20+anti-miR-520c-3p group had a higher number of stromal like cells, a lower number of epithelioid cells, tighter microtubule arrangement, and more microtubule nodules. miR-520c-3p and E-cadherin were downregulated, while RAB22A, N-cadherin, and vimentin were upregulated (P < 0.05). The transplanted tumor of OSCC in sh-SNHG20 group was smaller and lower than that in sh-NC group. The expression levels of LncRNA SNHG20 and RAB22A in the transplanted tumor tissues were lower than those in sh-NC group, and the expression level of miR-520c-3p was higher than that in sh-NC group (P < 0.05).CONCLUSIONLncRNA SNHG20 promotes epithelial-mesenchymal transition and microtubule formation in human oral squamous cell carcinoma cells by targeting the miR-520c-3p/RAB22A pathway. Inhibiting the expression of LncRNA SNHG20 can target and regulate the miR-520c-3p/RAB22A pathway to inhibit EMT and microtubule formation in OSCC cells.

01 Apr 2024·Cancer Biotherapy and RadiopharmaceuticalsQ4 · MEDICINE

Knockdown of lncRNA SNHG20 Suppressed the Proliferation of Cholangiocarcinoma by Sponging miR-520f-3p

Q4 · MEDICINE

Article

Author: Li, Wenzhi ; Jiang, Xingming ; Guan, Canghai ; Wang, Weina ; Hu, Zengtao ; Zhao, Yuqiao ; Liu, Lang

Objective: A large number of studies had found that small nucleolar RNA host gene 20 (SNHG20) was a long noncoding RNA (lncRNA) that played important regulatory functions in numerous tumors. Nevertheless, the expression and pathophysiological role of SNHG20 in cholangiocarcinoma (CCA) are currently unclear. The objective of this study is to reveal the clinical significance and pathophysiological function of SNHG20 in CCA. Methods: The tumor tissues and adjacent normal tissues of CCA were obtained to determine the expression and clinical significance of SNHG20, and the targets of related genes were predicted through bioinformatics analysis. The function and regulatory mechanism of SNHG20 in CCA were evaluated by transfection, CCK-8 experiment, and luciferase reporter assay. Result: In CCA, SNHG20 was highly expressed. Overexpressed SNHG20 was markedly interrelated with the lymph node invasion and TNM stage. In addition, it could be used as indicator to evaluate the prognosis of patients. SNHG20 sponging miR-520f-3p could accelerate the proliferation of CCA tumor cells. MiR-520f-3p acted as a tumor suppressor in CCA and could also serve as a prognostic indicator. Abolition of miR-520f-3p caused an antagonistic effect and diminished the impacts of SNHG20 knockdown. SNHG20 combined with miR-520f-3p could better predict the prognosis of CCA patients. Conclusion: These data confirmed the knockdown SNHG20 expression in CCA could inhibit the proliferation by means of sponging miR-520f-3p.

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SNHG20

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