LCE1D

Last update 08 May 2025

Basic Info

Synonyms

late cornified envelope 1D, Late cornified envelope protein 1D, Late envelope protein 4

+ [2]

Introduction

Precursors of the cornified envelope of the stratum corneum.

100 Clinical Results associated with LCE1D

100 Translational Medicine associated with LCE1D

0 Patents (Medical) associated with LCE1D

Literatures (Medical) associated with LCE1D

18 Feb 2025·Cardiovascular & Hematological Disorders-Drug Targets

Machine Learning for Chromatin Regulators in Coronary Artery Disease Diagnosis

Article

Author: Li, Wanying ; Zhao, Mei ; Zheng, Jinghui ; Ma, Xiaocong ; Wang, Ding ; Peng, Simin

Objective:This study aims to investigate the mechanisms underlying the role of chromatin regulator-related genes (CRRGs) in coronary artery disease (CAD) and develop a diagnostic model for CAD.Methods:We downloaded CAD datasets from the GEO database and utilized R software for machine learning, modeling, and classification of CAD based on CRRGs.Results:The random forest model was found to be the best approach, identifying USP44, MOCS1, SSRP1, ZNF516, and SCML1 as the top contributing genes for CAD diagnosis and prevention. Differentially expressed CRRGs were associated with aberrant immune cell infiltration in CAD patients. CAD patients were classified into two subtypes based on the expression of differentially expressed CRRGs. The differential expression analysis identified MMP9, LCE1D, LOC92659, SYNGR4, EN2, CACNA1E, GPR78, and LOC92249 as differentially expressed genes distinguishing the two subtypes of CAD. Functional analyses revealed that the differentially expressed genes are enriched in biological processes related to cellular functions, such as responses to metal ions and inorganic substances. The enriched pathways included inflammation and hormone-related pathways, such as IL-17 signaling, endocrine resistance, TNF signaling, and estrogen signaling pathways.Conclusion:CAD is associated with CRRGs, which may represent a new direction for CAD treatment.

01 Jan 2022·Acta virologicaQ4 · MEDICINE

Acetylation of late expression factor 4 is crucial for the transcription and proliferation of Bombyx mori nucleopolyhedrovirus

Q4 · MEDICINE

Article

Author: Mao, Fuxiang ; Gao, Xu ; Obeng, Enoch ; Yu, Wei ; Ngowo, Jonas ; Zhu, Yajie ; Lei, Jihai

Late expression factor 4 (LEF4), RNA polymerase subunit of Bombyx mori nucleopolyhedrovirus (BmNPV), plays an enzymatic role to enhance the capping of pre-mRNA of late and very late genes. Lysine acetylation is a post-translational modification process having many important functions associated with the regulation of a gene expression. Our previous study on lysine acetylome in BmNPV infected BmN cells showed that LEF 4 was acetylated at lysine 76 (K76). However, it is still unclear whether the modification of K76 residue contributes to the modulation of viral gene transcription. To elucidate the role played by acetylation or deacetylation of LEF4 K76 in the transcription of viral genes, we constructed acetylation mimicking and deacetylation mimicking mutant virus, K76Q and K76R, respectively. We then transfected BmN cells with these mutants and analyzed the level of pre-mRNA at different times. The K76R showed a significant decrease in the mRNA transcription level of vp39 and p10 genes at 48 and 72 h post-transfection, while K76Q did not show any significant changes compared with lef4-Wt. We further detected the virus titer of lef4-Wt, K76Q [et] K76R, and it was found that K76R impaired the virus infectivity ability at 72 and 96 h, while K76Q did not affect the virus infectivity. Moreover, the yeast two hybrid technique (Y2H) showed that both mutants (K76Q [et] K76R) affected the association of LEF 4 with the P47 protein. Taken together, these results indicated that acetylation modification of K76 is important for the proper transcription of late and very late genes, and the effectiveness of viral infection. Keywords: BmNPV lef4 gene; lysine acetylation, late genes transcription; BmNPV p47 gene; infectivity.

01 May 2015·Forensic Science International: GeneticsQ2 · MEDICINE

RNA/DNA co-analysis from human skin and contact traces – results of a sixth collaborative EDNAP exercise

Q2 · MEDICINE

Article

Author: B. Hjort ; P. Miniati ; W. Parson ; Á. Carracedo ; I. Gomes ; C. Courts ; E. Sauer ; H. Niederstätter ; F. Noël ; P. Hoff-Olsen ; K. Drobnic ; A. Kondili ; O. Maroñas ; C. Hollard ; S.A. Harbison ; E. Hanson ; A. Vidaki ; C. Keyser ; M. Turanská ; G. Shanthan ; N. Morling ; L. Zatkalíková ; M. Vennemann ; G. De Cock ; A.D. Roeder ; M.J. Porto ; G. Hadzic ; C. Franchi ; M. van den Berge ; A. Berti ; R. Banemann ; P.M. Schneider ; D. Syndercombe Court ; J. Ballantyne ; R. Fleming ; N. McCallum ; T. Sijen ; A.M. Bento ; C. Haas

The European DNA profiling group (EDNAP) organized a sixth collaborative exercise on RNA/DNA co-analysis for body fluid/tissue identification and STR profiling. The task was to identify skin samples/contact traces using specific RNA biomarkers and test three housekeeping genes for their suitability as reference genes. Eight stains, a skin RNA dilution series and, optionally, bona fide or mock casework samples of human or non-human origin were analyzed by 22 participating laboratories using RNA extraction or RNA/DNA co-extraction methods. Two sets of previously described skin-specific markers were used: skin1 pentaplex (LCE1C, LCE1D, LCE2D, IL1F7 and CCL27) and skin2 triplex (LOR, KRT9 and CDSN) in conjunction with a housekeeping gene, HKG, triplex (B2M, UBC and UCE). The laboratories used different chemistries and instrumentation. All laboratories were able to successfully isolate and detect mRNA in contact traces (e.g., human skin, palm-, hand- and fingerprints, clothing, car interiors, computer accessories and electronic devices). The simultaneous extraction of RNA and DNA provides an opportunity for positive identification of the tissue source of origin by mRNA profiling as well as a simultaneous identification of the body fluid donor by STR profiling. The skin markers LCE1C and LOR and the housekeeping gene marker B2M were detected in the majority of contact traces. Detection of the other markers was inconsistent, possibly due to the low amounts and/or poor quality of the genetic material present in shed skin cells. The results of this and the previous collaborative RNA exercises support RNA profiling as a reliable body fluid/tissue identification method that can easily be combined with current STR typing technology.

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LCE1D

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