DLGAP5

Last update 08 May 2025

Basic Info

Synonyms

DAP-5, Discs large homolog 7, Disks large-associated protein 5

+ [8]

Introduction

Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.

100 Clinical Results associated with DLGAP5

100 Translational Medicine associated with DLGAP5

0 Patents (Medical) associated with DLGAP5

261

Literatures (Medical) associated with DLGAP5

01 Jun 2025·Biochemical and Biophysical Research Communications

Vitamin K2 mitigates cognitive, and motor impairments induced by multiple surgery with anesthesia and analgesia in neonatal stage

Article

Author: Li, Zhichao ; Liu, Qidong ; Wang, Runjia ; Li, Shuai ; Hou, Qi ; Xu, Xiyuan ; Hou, Yu ; Zheng, Hui ; Shen, Yuan ; Ma, Linhui

Anesthesia and analgesia are essential components for surgical procedures. While the neurotoxic effects of multiple anesthesia exposures during brain development are well established, the combined impact of multiple surgery with anesthesia and analgesia exposures on neurodevelopmental remains unknown. In this study, neonatal mice underwent multiple surgery with fentanyl and sevoflurane (MSFS) exposures on postnatal days 6, 8, and 10, resulting in attention deficit hyperactivity disorder (ADHD)-like hyperactivity, impulsive behavior, cognitive impairment, and fine motor dysfunction in adulthood. Additionally, MSFS exposures inhibited neurogenesis in the nucleus accumbens (NAc) by reducing neural stem cells (NSCs) proliferation and differentiation into neurons and astrocytes. Pre-administration of Vitamin K2 (VK2) 30 min before each MSFS procedure significantly mitigated the behavioral impairments and restored neurogenesis. RNA-sequencing revealed that MSFS treatment induced 75 up-regulated and 140 down-regulated differentially expressed genes (DEGs) in the NAc, while VK2 pre-administration resulted in 149 up-regulated and 56 down-regulated DEGs. Among these, 32 DEGs were down-regulated by MSFS but restored by VK2 and 12 DEGs were up-regulated by MSFS but down-regulated by VK2. To identify key regulatory genes modulated by VK2, we performed protein-protein interaction analysis using CytoHubba, which revealed 10 hub genes-DLGAP5, TPX2, KIF20B, PLK1, SGO1, GTSE1, ASPM, CDCA2, BUB1B, and NUSAP1-with critical roles in cell cycle, cell division and NSCs pathways. The expression of hub genes was validated by RT-qPCR and immunofluorescence staining. These findings suggest that MSFS-induces ADHD-like behaviors, cognitive impairment, fine motor dysfunction, impaired neurogenesis and altering genes expression involved in cell cycle, cell division and NSCs pathways, which are rescued by VK2. This study presents the clinically MSFS model for investigating neurodevelopmental toxicity and highlights VK2's potential as a neuroprotective agent in pediatric involving multiple surgery with anesthesia and analgesia.

01 May 2025·Pathology - Research and Practice

Discovering potential therapeutic targets in glioblastoma multiforme using a multi-omics approach

Article

Author: Alajmi, Mohamed F ; Fatima, Urooj ; Hassan, Md Imtaiyaz ; Ansari, Jaoud ; Saeed, Mohammad Umar ; Mohammad, Taj ; Choudhury, Arunabh ; Hussain, Afzal

BACKGROUNDGlioblastoma multiforme (GBM) is a highly aggressive primary brain tumor associated with high fatality rates, poor prognosis, and limited treatment options. In this study, we utilized RNA-Seq gene count data from GBM patients, sourced from the Gene Expression Omnibus (GEO) database, to conduct an in-depth analysis of gene expression patterns.METHODSOur investigation involved stratifying samples into two distinct sets, Group I and Group II, comparing normal, low-grade, and GBM tumor samples, respectively. Subsequently, we performed differential expression analysis and enrichment analysis to uncover significant gene signatures. To elucidate the protein-protein interactions associated with GBM, we used the STRING plugin within Cytoscape for comprehensive network visualization and analysis.RESULTSBy applying Maximal clique centrality (MCC) scores, we identified a set of 10 hub genes in each group. These hub genes were subjected to survival analysis, highlighting their prognostic relevance. In Group I, comprising BUB1, DLGAP5, BUB1B, CDK1, TOP2A, CDC20, KIF20A, ASPM, BIRC5, and CCNB2, these genes emerged as potential biomarkers associated with the transition to low-grade tumors. In Group II, genes such as LIF, LBP, CSF3, IL6, CCL2, SAA1, CCL20, MMP9, CXCL10, and MMP1 were found to be involved in the transformation to adult glioblastoma. Kaplan-Meier's overall survival analysis of these hub genes revealed that modifications, particularly the upregulation of these candidate genes, were associated with reduced survival in GBM patients.CONCLUSIONSThe findings established the significance of genomic alterations and differential gene expression in GBM, presenting opportunities for prognostic and targeted therapeutic interventions. This study provides valuable insights into potential avenues for enhancing the clinical management of GBM.

01 Apr 2025·Immunity, Inflammation and Disease

Quantitative Proteomic Analysis Indicates That Pggt1b Deficiency Promotes Cytokine Secretion in Resiquimod‐Stimulated Bone Marrow‐Derived Macrophages via the NF‐κB Pathway

Article

Author: Yu, Shanshan ; Hao, Zhimin ; Gu, Heng ; Long, Fangyuan ; Wei, Xuecui

ABSTRACTBackgroundPsoriasis is a systemic inflammatory skin disease mediated by the innate and adaptive immune systems. Recent studies have indicated that macrophages may contribute to the pathogenesis of psoriasis. However, the role of macrophage protein geranylgeranyl transferase type‐1β subunit (PGGT1B) in psoriasis is unclear. In this study, we aimed to establish how a reduction in Pggt1b expression in monocytes influences the onset and progression of psoriasis.MethodsMyeloid cell‐specific Pggt1b knockout mice were generated, and their bone marrow‐derived macrophages (BMDMs) were stimulated with resiquimod (R848) to mimic the psoriatic immune microenvironment. The proteomic analysis enabled us to identify 17 differentially expressed proteins associated with Pggt1b deficiency in the psoriasis macrophage model (folded change ≥ 1.3 and p < 0.05). Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment was performed. Quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR) and western blot assays were used to verify the differentially expressed proteins and signaling pathways. Finally, an enzyme‐linked immunosorbent assay was used to verify the expression of the key inflammatory cytokine interleukin (IL)‐1β.ResultsIn total, six proteins (Dlgap5, Fas, Fnta, Nlrp3, Cd14, and Ticam2) were identified as hub proteins. Furthermore, we found that Pggt1b might mediate R848‐induced inflammation via the small G‐proteins Rac1 or Cdc42. We found that Pggt1b positively regulates pro‐inflammatory responses in R848‐stimulated BMDMs via the NF‐κB signaling pathway.ConclusionsThis study clarified that PGGT1B affected the synthesis of inflammatory cytokines via NF‐κB pathway and provided insights into the mechanisms underlying immune responses and inflammation.

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DLGAP5

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