STOML3

Last update 08 May 2025

Basic Info

Synonyms

Epb7.2l, SLP-3, SRO

+ [3]

Introduction

Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations.

100 Clinical Results associated with STOML3

100 Translational Medicine associated with STOML3

0 Patents (Medical) associated with STOML3

166

Literatures (Medical) associated with STOML3

08 Feb 2025·Nucleic Acids Research

Allovalent scavenging of activation domains in the transcription factor ANAC013 gears transcriptional regulation

Article

Author: O’Shea, Charlotte ; Morffy, Nicolas ; Skriver, Karen ; Strader, Lucia C ; Theisen, Frederik Friis ; Blackledge, Martin ; Due, Amanda D ; Delaforge, Elise ; Kragelund, Birthe B

AbstractTranscriptional regulation involves interactions between transcription factors, coregulators, and DNA. Intrinsic disorder is a major player in this regulation, but mechanisms driven by disorder remain elusive. Here, we address molecular communication within the stress-regulating Arabidopsis thaliana transcription factor ANAC013. Through high-throughput screening of ANAC013 for transcriptional activation activity, we identify three activation domains within its C-terminal intrinsically disordered region. Two of these overlap with acidic islands and form dynamic interactions with the DNA-binding domain and are released, not only upon binding of target promoter DNA, but also by nonspecific DNA. We show that independently of DNA binding, the RST (RCD--SRO--TAF4) domain of the negative regulator RCD1 (Radical-induced Cell Death1) scavenges the two acidic activation domains positioned vis-à-vis through allovalent binding, leading to dynamic occupation at enhanced affinity. We propose an allovalency model for transcriptional regulation, where sequentially close activation domains in both DNA-bound and DNA-free states allow for efficient regulation. The model is likely relevant for many transcription factor systems, explaining the functional advantage of carrying sequentially close activation domains.

07 Jan 2025·Microbiology Spectrum

Mitochondrial targeting of Candida albicans SPFH proteins and requirement of stomatins for SDS-induced stress tolerance

Article

Author: Kim, Hyunjeong ; Chen, Xiao ; Heredia, Marienela Y. ; Rauceo, Jason M. ; Hernday, Aaron D. ; Ahmed, Maisha ; Callender, Tracy L. ; Qasim, Mohammad

ABSTRACT The SPFH (stomatin, prohibitin, flotillin, and HflK/HflC) protein superfamily is conserved across all domains of life. Fungal SPFH proteins are required for respiration, stress adaptation, and membrane scaffolding. In the yeast Candida albicans , stomatin-like protein 3 (Slp3) forms punctate foci at the plasma membrane, and SLP3 overexpression causes cell death following exposure to the surfactant, SDS, and the oxidative stressor, H 2 O 2 . Here, we sought to determine the cellular localization and functionally characterize stomatin-like protein 2 (Slp2), prohibitin-1 (Phb1), prohibitin-2 (Phb2), and prohibitin-12 (Phb12) in C. albicans . Cytological and western blotting results showed that Slp2-Gfp/Rfp and prohibitin-Gfp fusion proteins localize to the mitochondrion in yeast cells. Growth assay results did not identify any respiration defects in a panel of stomatin and prohibitin mutant strains, suggesting that SPFH respiratory function has diverged in C. albicans from other model eukaryotes. However, a slp2Δ / Δ / slp3Δ / Δ double mutant strain grew poorly in the presence of 0.08% SDS, accumulated intracellular reactive oxidative species, and displayed aberrant ergosterol distribution in the plasma membrane. These phenotypes were not observed in slp2Δ / Δ or slp3Δ / Δ single mutants, indicating a possible indirect genetic interaction between SLP2 and SLP3 . In addition, slp2Δ / Δ and slp2Δ / Δ / slp3Δ / Δ mutant strains were slightly resistant to the antifungal drug, fluconazole. Collectively, these findings reveal the cellular localization of Slp2, Phb1, Phb2, and Phb12, highlight the significance of stomatins in C. albicans SDS stress tolerance, and, for the first time, associate stomatins with antifungal resistance. IMPORTANCE Stomatins and prohibitins coordinate respiration and stress adaptation in fungi. Invasive mycoses caused by Candida albicans are a significant cause of morbidity, and candidemia patients show high mortality rates worldwide. Mitochondria are essential for C. albicans commensalism and virulence, and mitochondrial proteins are targets for antifungal interventions. C. albicans encodes five SPFH proteins: two stomatin-like proteins and three prohibitins. We have previously shown that Slp3 is important for C. albicans adaptation to various types of environmental stress. Moreover, synthetic compounds that bind to mammalian prohibitins inhibit C. albicans filamentation and are fungicidal. However, there is limited information available regarding the remaining SPFH proteins. Our findings show that mitochondrial localization of SPFH proteins is conserved in C. albicans . In addition, we demonstrate the importance of stomatins in plasma membrane and mitochondrial stress tolerance.

31 Dec 2024·Plant Signaling & Behavior

Genome-wide identification of SIMILAR to RCD ONE (SRO) gene family in rapeseed ( Brassica napus L.) reveals their role in drought stress response

Article

Author: Li, Jia ; Tang, Rongzi ; Tang, Rong ; Liang, Fenghao ; Zhang, Chao ; Zhou, Yuyu ; Jiang, Huanhuan ; Zhang, Yuling

Rapeseed (Brassica napus L.) is an important oilseed crop widely cultivated worldwide, and drought is the main environmental factor limiting its yield enhancement and the expansion of planted areas. SIMILAR TO RCD ONE (SRO) is a plant-specific small gene family that plays a crucial role in plant growth, development, and responses to abiotic stresses such as drought. However, the functional role of SROs in rapeseed remains poorly understood. In this study, 19 BnaSROs were identified from the rapeseed genome, with 9, 10, 10, 18, and 20 members identified from the genomes of Brassica rapa, Brassica nigra, Brassica oleracea, Brassica juncea, and Brassica carinata, respectively. We then analyzed their sequence characteristics, phylogenetic relationships, gene structures, and conserved domains, and explored the collinearity relationships of the SRO members in Brassica napus and Brassica juncea. Next, we focused on the analysis of tissue expression and stress-responsive expression patterns of rapeseed SRO members and examined their expression profiles under ABA, MeJA and water-deficit drought treatments using qPCR. Transcriptome data analysis and qPCR detection indicated that BnaSROs exhibit multiple stress-responsive expression patterns. BnaSRO1 and BnaSRO11, which are likely to function through interactions with NAC transcription factors, were screened as major drought-regulated members. Our results provide a solid foundation for functional analysis of the role of the SRO gene family in abiotic stress responses, especially drought stress responses, in rapeseed.

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STOML3

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