GRK7

Last update 08 May 2025

Basic Info

Synonyms

G protein-coupled receptor kinase 7, G protein-coupled receptor kinase GRK7, GPRK7

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Introduction

Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).

100 Clinical Results associated with GRK7

100 Translational Medicine associated with GRK7

0 Patents (Medical) associated with GRK7

109

Literatures (Medical) associated with GRK7

01 Apr 2025·Acta Pharmacologica Sinica

Smad transcription factors as mediators of 7 transmembrane G protein-coupled receptor signalling

Review

Author: Chia, Zheng-Jie ; Kumarapperuma, Hirushi ; Little, Peter J ; Zhang, Ruizhi ; Kamato, Danielle ; Little, Peter J.

AbstractThe Smad transcription factors are well known for their role at the core of transforming growth factor-β (TGF-β) signalling. However, recent evidence shows that the Smad transcription factors play a vital role downstream of other classes of receptors including G protein-coupled receptors (GPCR). The versatility of Smad transcription factors originated from the two regions that can be differently activated by the TGF-β receptor superfamily or through the recruitment of intracellular kinases stimulated by other receptors classes such as GPCRs. The classic GPCR signalling cascade is further expanded to conditional adoption of the Smad transcription factor under the stimulation of Akt, demonstrating the unique involvement of the Smad transcription factor in GPCR signalling pathways in disease environments. In this review, we provide a summary of the signalling pathways of the Smad transcription factors as an important downstream mediator of GPCRs, presenting exciting opportunities for discovering new therapeutic targets for diseases.

05 Mar 2025·Molecular Biology and Evolution

Widespread and Convergent Evolution of Cone Monochromacy in Galeomorph Sharks

Article

Author: Gaston, Troy F ; Hart, Nathan S ; Williamson, Jane E ; Ryan, Laura A ; Seeger, Olivia ; Tosetto, Louise ; Pozo-Montoro, Maria ; Peddemors, Victor M ; Huveneers, Charlie

AbstractColor vision is widespread in marine vertebrates but is notably lacking in whales, dolphins, seals, and apparently also sharks. All sharks studied to date possess only a single spectral class of cone and are thus potentially totally color blind. The reason why sharks lack color vision is unclear, but as the visual pigments of only a handful of this large and ecologically diverse taxon have been studied, more data are required to address this question. Here, we assembled the retinal transcriptomes of 9 species from 7 families and 3 orders within the superorder Galeomorphii to screen for visual opsin and phototransduction genes. We reveal that cone monochromacy is widespread in galeomorph sharks, but the type of cone opsin expressed varies, with lamniform and orectolobiform sharks expressing a long-wavelength-sensitive (LWS) opsin, and carcharhiniform and heterodontiform sharks expressing a rhodopsin-like 2 (RH2) opsin. Cone monochromacy has evolved from a dichromatic ancestral state at least 4 times, implying strong selection pressure to prioritize achromatic over chromatic vision. While all species express the GRK1A and GRK7 isoforms of G protein-coupled receptor kinase, only sharks with the LWS cone opsin express the GRK1B isoform, which suggests that nonspectral functions of photoreception may have influenced, or result from, the opsin complement in the shark retina. Finally, we show that the shark rod (RH1) opsin gene shows evidence of positive selection at sites known to influence pigment kinetics (i.e. metarhodopsin II stability) and that the rate of retinal release likely differs substantially between species in ways that reflect their physiology and ecology.

01 Aug 2024·Cancer Genetics

Novel gene fusions in human oropharyngeal carcinoma

Article

Author: Matsushita, Hirokazu ; Masago, Katsuhiro ; Horio, Yoshitsugu ; Fujita, Shiro ; Ishihara, Hiromasa ; Hanai, Nobuhiro ; Fujita, Yasuko ; Sasaki, Eiichi ; Kuroda, Hiroaki ; Endo, Motoyoshi

Few reports have analyzed the fusion genes involved in carcinogenesis in the oropharynx, where the incidence of human papillomavirus-associated tumors is relatively low. The aim of this study was to identify novel driver fusion genes in patients with oropharyngeal cancer. The study enrolled fifty-seven patients who were diagnosed with oropharyngeal carcinoma. RNA sequencing data from fresh-frozen specimens were used to identify candidate fusion genes via the JAFFA, arriba, and STAR-Fusion pipelines. Candidate fusion genes were confirmed by direct sequencing. The expression level of a candidate fusion gene was compared to that of tumors without fusion genes. Finally, filtering was performed for driver genes using the annoFuse pipeline. In addition, the VIRTUS pipeline was used to analyze the presence of human papillomavirus in the tumors. We identified 5 (8.8 %) novel potential driver in-frame fusion genes, MKNK2::MOB3A, ICMT::RPS6KA3, ATP1B3::GRK7, CSNK2A1::KIF16B, and FGFR3::MAEA, and 1 (1.8 %) known in-frame fusion gene, FGFR3::TACC3, in 57 patients with pharyngeal carcinoma. Our results suggest that sporadic fusion genes may contribute to tumorigenesis in oropharyngeal carcinomas.

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GRK7

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