KLHL31

Last update 08 May 2025

Basic Info

Synonyms

bA345L23.2, BKLHD6, BTB and kelch domain-containing protein 6

+ [7]

Introduction

Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).

100 Clinical Results associated with KLHL31

100 Translational Medicine associated with KLHL31

0 Patents (Medical) associated with KLHL31

Literatures (Medical) associated with KLHL31

01 Jun 2025·European Journal of Cell Biology

The dual nature of KLHL proteins: From cellular regulators to disease drivers

Review

Author: Giordano, Antonio ; Carletti, Erminia ; Cavallo, Luigi Maria ; Berardinelli, Jacopo ; Morrione, Andrea ; Solari, Domenico ; De Luca, Antonella ; Barboni, Barbara ; Canciello, Angelo ; Di Giulio, Verdiana ; Russo, Valentina

The Kelch-like (KLHL) protein family, characterized by its conserved BTB, BACK, and Kelch domains, serves as substrate adaptors for Cullin 3-RING ligases (CRL3), facilitating the ubiquitination and degradation of specific target proteins. Through this mechanism, KLHL proteins regulate numerous physiological processes, including cytoskeletal organization, oxidative stress response, and cell cycle progression. Dysregulation of KLHL proteins-via mutations or abnormal expression-has been implicated in various pathological conditions, including neurodegenerative disorders, cancer, cardiovascular diseases, and hereditary syndromes. This review provides a comprehensive overview of the physiological and pathological roles of KLHL proteins, emphasizing their specific substrates and mechanisms of action. By integrating structural and mechanistic insights with translational research, this review underscores the potential of KLHL proteins as promising therapeutic targets, offering new opportunities to combat a wide spectrum of complex diseases.

01 Apr 2024·European Journal of Medicinal Chemistry

Targeting kelch-like (KLHL) proteins: achievements, challenges and perspectives

Review

Author: Jiang, Zhengyu ; Hu, Xiuqi ; Zhou, Yangguo ; Zhao, Ziquan ; Zhang, Qiong ; You, Qidong

Kelch-like proteins (KLHLs) are a large family of BTB-containing proteins. KLHLs function as the substrate adaptor of Cullin 3-RING ligases (CRL3) to recognize substrates. KLHLs play pivotal roles in regulating various physiological and pathological processes by modulating the ubiquitination of their respective substrates. Mounting evidence indicates that mutations or abnormal expression of KLHLs are associated with various human diseases. Targeting KLHLs is a viable strategy for deciphering the KLHLs-related pathways and devising therapies for associated diseases. Here, we comprehensively review the known KLHLs inhibitors to date and the brilliant ideas underlying their development.

01 Mar 2024·Heliyon

Characterization of KLHL14 anti-oncogenic action in malignant mesothelioma

Article

Author: Morrione, Andrea ; Domínguez, Reyes Benot ; Canciello, Angelo ; Giordano, Antonio ; Barboni, Barbara

Malignant mesothelioma (MM) is a very aggressive neoplasia with a short life expectancy and limited therapeutic options. Thus, the identification of novel molecular targets is a matter of great urgency. Kelch-like (KLHL) proteins play an important role in a number of physiological and pathological cell-regulatory processes. Among this family, the function of KLHL14 is still very poorly characterized. KLHL14 was originally identified as a gene involved in regulating the epithelial-mesenchymal transition (EMT) process. Here, we demonstrate that KLHL14 not only prevents EMT but also plays an anti-oncogenic role in MM. Indeed, KLHL14 depletion enhanced proliferation, motility, invasion and colony formation in MM cells. Importantly, we also demonstrated that KLHL14 mechanism of action is dependent on Transforming Growth Factor β (TGF-β). In fact, TGF-β promotes de novo synthesis, increases protein stability and induces nuclear-cytoplasmic shuttling of KLHL14. Collectively, this research is an important step further to decipher KLHLs mechanism of action and further contributes to the understanding of the molecular mechanisms regulating MM.

Analysis

Perform a panoramic analysis of this field.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

KLHL31

Basic Info

Related

Analysis