GCFC2

Last update 08 May 2025

Basic Info

Synonyms

C2orf3, DNABF, GC-rich sequence DNA-binding factor

+ [7]

Introduction

Involved in pre-mRNA splicing through regulating spliceosome C complex formation (PubMed:24304693). May play a role during late-stage splicing events and turnover of excised introns (PubMed:24304693).

100 Clinical Results associated with GCFC2

100 Translational Medicine associated with GCFC2

0 Patents (Medical) associated with GCFC2

246

Literatures (Medical) associated with GCFC2

01 May 2025·Journal of Oral Biology and Craniofacial Research

The influence of chronic periodontitis and type 2 diabetes mellitus on resistin levels of gingival crevicular fluid- a systematic review and meta-analysis

Review

Author: Gupta, Alpa ; Mrinalini, Mrinalini ; Abraham, Dax ; Duraisamy, Arun Kumar

AimChronic periodontitis (CP), a prevalent inflammatory dental disease, has been linked to systemic conditions like Type 2 Diabetes Mellitus (T2DM). This systematic review and meta-analysis aimed to evaluate resistin levels in the Gingival Crevicular Fluid (GCF) of CP individuals with T2DM. The objective was to determine if resistin could be a potential biomarker for periodontal disease in T2DM individuals.MethodsThe review included data from seventeen clinical studies that investigated resistin levels in GCF of individuals diagnosed with CP and T2DM. Data were sourced from PubMed, Scopus, and EBSCOhost, selected for their extensive coverage of medical and dental research, ensuring thorough retrieval of relevant studies. From the initial seventeen studies, five complied with the strict inclusion criteria for meta-analysis.ResultsUsing a comprehensive meta-analysis, the significance of GCF Resistin levels in individuals with CP and T2DM relative to the healthy groups was examined. In addition, a meta-analysis was carried out to look into the relationship between periodontal probing depth (PPD) and CP and T2DM. The results indicated that individuals with T2DM and CP had significantly higher GCF resistin levels than the other groups. Furthermore, the PPD in T2DM with CP was significantly greater than in the other groups.ConclusionThe present review highlights the potential role of resistin as a biomarker to diagnose individuals with chronic periodontitis and T2DM.Clinical significanceThe significantly elevated levels of resistin suggest that resistin could serve as a potential biomarker for T2DM in individuals with CP. This could lead to improved methods of early diagnosis and treatment, which could enhance individual outcomes and quality of life.Prospero registrationThe registration number CRD42023467186.

01 Mar 2025·Oral Diseases

Gingival crevicular fluid levels of TLR‐9, AIM‐2, and ZBP‐1 in periodontal diseases

Article

Author: Atmaca, Harika ; Köse, Timur ; Emingil, Gülnur ; Öztürk, Veli Özgen ; Yılmaz, Büşra ; Kantarcı, Alpdoğan

AbstractObjectivesToll‐like receptor (TLR)‐9, may play a role in periodontal disease inflammation. This study measured TLR‐9 and its related molecules, absence in melanoma‐2 (AIM‐2) and Z‐DNA‐binding protein‐1 (ZBP‐1), in gingival crevicular fluid (GCF) from patients with varying stages of periodontal disease to assess the role of pathogen‐derived nucleic acids in inflammation.Materials and MethodsThe study comprised 80 participants: 20 with Stage III Grade C periodontitis, 20 with Stage III Grade B periodontitis (P‐Stage III‐B), 19 with gingivitis, and 21 with periodontal health. Parameters including probing depth (PD), clinical attachment level (CAL), plaque index (PI), and bleeding on probing (BOP) were recorded. ELISA was used to analyze TLR‐9, AIM‐2, and ZBP‐1 levels in GCF. Nonparametric tests were used for statistical comparisons.ResultsThe total amount of TLR‐9 was higher in P‐Stage III‐B than in the healthy group (p < 0.05). Similarly, the gingivitis group exhibited elevated GCF TLR‐9 levels compared to the healthy group (p < 0.05). GCF AIM‐2 and ZBP‐1 levels remained consistent across groups (p > 0.05). Significant correlations were found between GCF TLR‐9 and CAL (p < 0.05), BOP (p < 0.05), PI (p < 0.01), and GCF volume (p < 0.001).ConclusionThese findings suggested that the TLR‐9‐mediated inflammatory process plays a role in periodontal disease, as evidenced by the increased levels of TLR‐9 in GCF.

01 Oct 2024·Journal of Dentistry

Association between calcium-channel blockers and gingival enlargement: A case-control study

Article

Author: Nibali, Luigi ; Hughes, Francis ; Lu, Emily Ming-Chieh ; Alamri, Meaad Mohammed ; Zoheir, Noha ; Mainas, Giuseppe ; Santamaria, Pasquale

OBJECTIVESAs reported by the existing literature, calcium-channel blockers (CCB) can lead to gingival enlargement. The aims of this study were to investigate the factors associated with gingival enlargement in patients on CCB and to assess the saliva and gingival crevicular fluid (GCF) profile of patients on CCB with gingival enlargement.METHODSA total of 131 participants were included. Data were collected from 91 patients taking CCB for treatment of systemic hypertension. The presence of drug-induced gingival enlargement (DIGE) was assessed clinically and associated with patient factors. Patients with DIGE were group-matched for gender and ethnicity with an equal number of consecutive CCB non-DIGE patients (control 1), no-CCB no-DIGE (control 2) and periodontally healthy with no DIGE (control 3) for the saliva and GCF analysis. A bead-based multiplex immunoassay was used to assess a panel of biomarkers.RESULTSTwenty-two percent of patients on CCB were diagnosed with DIGE. Lack of daily interdental cleaning and self-reported diagnosis of type II diabetes were associated with the diagnosis of DIGE. When analysing patients only on CCB, those with DIGE had higher GCF levels of vascular endolthelial growth factor (VEGF) (p = 0.032), epidermal growth factor (EGF) (p = 0.030) and matrix metalloproteinase-8 (MMP-8) (p = 0.008). Among the salivary markers, only MMP-8 showed a statistically significant difference across groups (p < 0.001).CONCLUSIONSThis is the first study investigating saliva and GCF biomarkers in patients with DIGE and different control groups, suggesting that causes of the overgrowth might involve inflammatory processes, tissue damage pathways, and potentially an impact on growth factors like VEGF. Future research should verify these results in independent populations and explore the underlying pathogenic mechanisms in-depth.CLINICAL SIGNIFICANCECalcium-channel blockers (CCB) can lead to gingival enlargement. This study confirms lack of interdental cleaning and type II diabetes as risk factors. Elevated levels of VEGF, EGF, and MMP-8 in gingival crevicular fluid and MMP-8 in saliva suggest inflammatory processes and growth factors might play roles in this condition.

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GCFC2

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