ZMAT5

Last update 08 May 2025

Basic Info

Synonyms

SNRNP20, U11/U12 small nuclear ribonucleoprotein 20 kDa protein, U11/U12 snRNP 20 kDa protein

+ [5]

Introduction-

100 Clinical Results associated with ZMAT5

100 Translational Medicine associated with ZMAT5

0 Patents (Medical) associated with ZMAT5

Literatures (Medical) associated with ZMAT5

01 Feb 2025·Molecular Cell

Structural basis of 5′ splice site recognition by the minor spliceosome

Article

Author: Zhao, Jiangfeng ; Galej, Wojciech P ; Brandina, Irina ; Peter, Daniel ; Liu, Xiangyang

The minor spliceosome catalyzes excision of U12-dependent introns from precursors of eukaryotic messenger RNAs (pre-mRNAs). This process is critical for many cellular functions, but the underlying molecular mechanisms remain elusive. Here, we report a cryoelectron microscopy (cryo-EM) reconstruction of the 13-subunit human U11 small nuclear ribonucleoprotein particle (snRNP) complex in apo and substrate-bound forms, revealing the architecture of the U11 small nuclear RNA (snRNA), five minor spliceosome-specific factors, and the mechanism of the U12-type 5' splice site (5'SS) recognition. SNRNP25 and SNRNP35 specifically recognize U11 snRNA, while PDCD7 bridges SNRNP25 and SNRNP48, located at the distal ends of the particle. SNRNP48 and ZMAT5 are positioned near the 5' end of U11 snRNA and stabilize binding of the incoming 5'SS. Recognition of the U12-type 5'SS is achieved through base-pairing to the 5' end of the U11 snRNA and unexpected, non-canonical base-triple interactions with the U11 snRNA stem-loop 3. Our structures provide mechanistic insights into U12-dependent intron recognition and the evolution of the splicing machinery.

01 May 2016·Journal of Experimental BotanyQ2 · BIOLOGY

The Arabidopsis homolog of human minor spliceosomal protein U11-48K plays a crucial role in U12 intron splicing and plant development

Q2 · BIOLOGY

Article

Author: Xu, Tao ; Kang, Hunseung ; Kwak, Kyung Jin ; Jung, Hyun Ju ; Kim, Bo Mi

The minor U12 introns are removed from precursor mRNAs by the U12 intron-specific minor spliceosome. Among the seven ribonucleoproteins unique to the minor spliceosome, denoted as U11/U12-20K, U11/U12-25K, U11/U12-31K, U11/U12-65K, U11-35K, U11-48K, and U11-59K, the roles of only U11/U12-31K and U11/U12-65K have been demonstrated in U12 intron splicing and plant development. Here, the functional role of the Arabidopsis homolog of human U11-48K in U12 intron splicing and the development of Arabidopsis thaliana was examined using transgenic knockdown plants. The u11-48k mutants exhibited several defects in growth and development, such as severely arrested primary inflorescence stems, formation of serrated leaves, production of many rosette leaves after bolting, and delayed senescence. The splicing of most U12 introns analyzed was impaired in the u11-48k mutants. Comparative analysis of the splicing defects and phenotypes among the u11/u12-31k, u11-48k, and u11/12-65k mutants showed that the severity of abnormal development was closely correlated with the degree of impairment in U12 intron splicing. Taken together, these results provide compelling evidence that the Arabidopsis homolog of human U11-48K protein, as well as U11/U12-31K and U11/U12-65K proteins, is necessary for correct splicing of U12 introns and normal plant growth and development.

01 Jun 2013·Head & NeckQ2 · MEDICINE

Search for chromosome rearrangements: New approaches toward discovery of novel translocations in head and neck squamous cell carcinoma

Q2 · MEDICINE

Article

Author: Vivian W. Wang ; David I. Smith ; Jian Ma ; Bruce W. Eckloff ; Rebecca R. Laborde ; Yan W. Asmann ; Kerry D. Olsen ; Eric J. Moore ; Yang Li ; Steven M. Olsen ; Nicole M. Tombers

AbstractBackgroundChromosome rearrangements that result in gene fusions have important roles in the initial steps of tumorigenesis, especially in leukemias and lymphomas, but the biological and clinical impact of gene fusions in common solid tumors are less understood. The purpose of this study was to discover novel translocations that could result in gene fusions in oropharyngeal squamous cell carcinomas (OPSCCs).MethodsTranslocations were identified using 2 different bioinformatics pipelines, SnowShoes‐FTD and FusionHunter, examining data from 11 paired‐end RNA sequencing (RNA‐Seq) data in OPSCC. Translocations were validated by RT‐PCR and Sanger sequencing analysis.ResultsTwo novel cancer‐specific translocations involving MGST3‐ZMAT5 and MS4A7‐C2CD3 were found in 2 of the tumor samples tested. However, these translocations were found only in the single tumor.ConclusionsWe hope that this integrative methodology will elucidate key aspects of tumor biology as well as generate novel targets for cancer diagnoses and therapies. Head Neck, 2012

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