ZBTB22

Last update 08 May 2025

Basic Info

Synonyms

BING1, fru, fruitless

+ [9]

Introduction

May be involved in transcriptional regulation.

100 Clinical Results associated with ZBTB22

100 Translational Medicine associated with ZBTB22

0 Patents (Medical) associated with ZBTB22

310

Literatures (Medical) associated with ZBTB22

01 Mar 2025·iScience

Contribution of neurons that express fruitless and Clock transcription factors to behavioral rhythms and courtship

Article

Author: Deluca, Anthony ; Arbeitman, Michelle N ; Bascom, Brooke ; Key Planas, Daniela A ; Kocher, Matthew A ; Torres, Marielise

Animals need to integrate information across neuronal networks that direct reproductive behaviors and circadian rhythms. The Drosophila master regulatory transcription factors that direct courtship and circadian rhythms are co-expressed. We find sex differences in the number of these fruitless (fru) and Clock (Clk)-expressing neurons (fru ∩ Clk neurons) regulated by male-specific Fru. We assign the fru ∩ Clk neurons to the electron microscopy connectome and to subtypes of clock neurons. We discover sex differences in fru-expressing neurons that are post-synaptic targets of Clk-expressing neurons. When fru ∩ Clk neurons are activated or silenced, we observe a male-specific shortening of period length. Activation of fru ∩ Clk neurons also changes the rate a courtship behavior is performed. We examine male courtship behavior over 24 h and find courtship activities peak at lights-on. These results reveal how neurons that subserve the two processes can impact behavioral outcomes in a sex-specific manner.

01 Feb 2025·Food Chemistry: X

Sweet-enhancing effect of coolant agent menthol evaluated via sensory analysis and molecular modeling

Article

Author: Chen, Chen ; Mao, Haifang ; Tian, Huaixiang ; Liu, Jibo ; Yu, Haiyan ; Ao, Ting

Responding to global trends favoring low-sugar diets, this study explored the potential of menthol, a cooling agent, to enhance sweet taste perception through integrated sensory evaluations and molecular modeling. The results of static sensory evaluation (recognition threshold determination, paired comparison test and 15 cm-linear scale) and dynamic sensory analysis indicated that menthol lowered sweetness threshold of HFCS (from 5.98 g/L to 5.02 g/L), while intensifying maximum sweetness intensity and prolonging the duration of sweetness. Sensory analysis identified optimal sweet enhancement at 0.004-0.030 g/L menthol concentrations, while 0.060 g/L caused sweetness suppression through intensified cooling/bitter sensations. Molecular modeling comparing T1R2/T1R3-Glu/Fru system and T1R2/T1R3-Glu/Fru/Men system elucidated that the addition of menthol increased the number of hotspot residues in protein-sugars binding and stabilized interactions by occupying sites near sugar active sites, maintaining the Venus Flytrap Domain in its closed, activated configuration. These findings demonstrated the underlying contribution menthol made to sweet enhancement and sugar reduction.

30 Oct 2024·The Journal of Neuroscience

Neurons Underlying Aggression-Like Actions That Are Shared by Both Males and Females inDrosophila

Article

Author: Ayembem, Deven ; Barranca, Victor J ; Tao, Liangyu ; Bhandawat, Vikas ; Ayambem, Deven ; Barranca, Victor J.

Aggression involves both sexually monomorphic and dimorphic actions. How the brain implements these two types of actions is poorly understood. We found that inDrosophila melanogaster, a set of neurons, which we call CL062, previously shown to mediate male aggression also mediate female aggression. These neurons elicit aggression acutely and without the presence of a target. Although the same set of actions is elicited in males and females, the overall behavior is sexually dimorphic. The CL062 neurons do not expressfruitless, a gene required for sexual dimorphism in flies, and expressed by most other neurons important for controlling fly aggression. Connectomic analysis in a female electron microscopy dataset suggests that these neurons have limited connections withfruitlessexpressing neurons that have been shown to be important for aggression and signal to different descending neurons. Thus, CL062 is part of a monomorphic circuit for aggression that functions parallel to the known dimorphic circuits.

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ZBTB22

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