Lumicell, Inc., a leader in fluorescence-guided imaging technologies for
cancer detection, has unveiled promising early clinical trial results from a study focusing on molecular imaging in
gastric cancer. These findings were highlighted during the American Association for Cancer Research (AACR) Annual Meeting, specifically in the "Advances in the Detection and Treatment of
Gastrointestinal Cancers" session organized by Stand Up To Cancer (SU2C).
Dr. Andrew T. Chan and Dr. David A. Drew from Massachusetts General Hospital presented groundbreaking research indicating that cathepsin activity could serve as a significant biomarker for gastric cancer. This discovery was made through single-cell analysis of patient samples and molecular profiling using genetically engineered mouse models. Their research supports the potential of
pegulicianine-fluorescence imaging technology to identify early-stage gastric tumors and those treated with neoadjuvant therapy effectively.
The first clinical trial of pegulicianine in patients with gastrointestinal cancer, conducted in partnership with Lumicell, was led by Dr. Drew and Dr. Chan. During the study, participants with diffuse and intestinal-type gastric cancers were administered pegulicianine intravenously before undergoing surgical procedures aimed at tumor removal. The results showed that post-surgical specimens exhibited strong, tumor-specific fluorescence signals that matched pathologically confirmed cancerous tissues. Notably, pegulicianine was well-tolerated by all participants in the study.
Dr. Chan emphasized the significance of these findings, noting that most gastric cancers are diagnosed at advanced stages, resulting in five-year survival rates below 30%. He pointed out that current screening methods, such as random biopsies during endoscopy, lack adequate sensitivity. The new findings highlight a potential shift towards more precise and early detection methods for gastric cancer.
Dr. Drew expressed excitement over the feasibility results, highlighting that this research is paving the way for real-time, in vivo endoscopic imaging. Such advancements could significantly enhance early detection strategies for gastric and gastroesophageal cancers in high-risk populations. The next phase of the research involves an in vivo clinical trial of pegulicianine, combined with Lumicell's newly developed endoscopic imaging system.
Lumicell, Inc. is a privately-owned company dedicated to developing fluorescence-guided imaging technologies for detecting cancerous tissue during surgeries. Their leading products are designed to illuminate cancerous tissues during initial lumpectomy procedures and are being explored for the potential to address a broad range of
solid tumor types. The company remains focused on advancing its technologies to improve cancer detection and treatment outcomes.
As Lumicell continues its research and development efforts, the potential impact of their innovations could be significant for improving survival rates and treatment efficacy in cancer patients. The ongoing collaboration with leading researchers and institutions underscores their commitment to transforming the landscape of cancer detection and aiding healthcare professionals in delivering more effective interventions.
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