Stock Soars on Promising Epilepsy Drug Trial, Longboard Eyes $150M Offering

3 June 2024
Longboard Pharmaceuticals recently reported promising results from its Phase Ib/IIa PACIFIC study, highlighting the effectiveness of its drug candidate bexicaserin in reducing seizures for individuals with developmental and epileptic encephalopathies (DEE). The study demonstrated a significant 53.3% decrease in motor seizures after a 28-day treatment period, with bexicaserin outperforming placebo by a placebo-adjusted reduction of 32.5%.

The company's Chief Medical Officer, Randall Kaye, expressed enthusiasm about the findings, suggesting that bexicaserin could become a leading product in the treatment of DEE, potentially setting a new standard for patient care. This optimism was reflected in the market, as Longboard's stock price surged by an impressive 316% following the announcement.

Bexicaserin is a 5-HT2C receptor superagonist that modulates mood, appetite, and motor behaviors by binding to the neurotransmitter serotonin. Its mechanism of action involves regulating the neurotransmitter GABA, which helps to reduce the hyperexcitability associated with seizures. Importantly, bexicaserin does not interact with the 5-HT2A or 5-HT2B receptor subtypes, which are known to cause toxicities and side effects.

In terms of patient safety, the most frequently reported side effects during the PACIFIC trial were gastrointestinal issues, fatigue, and decreased appetite. Serious adverse events were rare, affecting only three participants. However, nine patients in the bexicaserin group withdrew from the study due to treatment-related toxicities, a factor that will need to be carefully considered as the drug progresses through further clinical trials.

The PACIFIC study was structured to evaluate the safety, tolerability, and efficacy of bexicaserin at varying doses, with patients titrating their dosage over a 15-day period before settling on their highest tolerated dose for a 60-day maintenance phase. Participants were permitted to continue stable anti-seizure medications throughout the study.

As Longboard prepares to present more data from the PACIFIC trial at upcoming medical conferences, the company is also advancing bexicaserin into Phase III development. The recent success has prompted Longboard to initiate a public offering, aiming to raise $150 million by issuing additional shares of its voting common stock.

While the initial results from the PACIFIC study are encouraging, further research and clinical trials will be crucial to fully understand the drug's potential and to ensure its safety and efficacy for patients with DEE. The journey from clinical trials to market availability is a complex and lengthy one, but the early signs are promising for those affected by these challenging conditions.

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