Brenig Therapeutics Presents New LRRK2 Inhibitor Findings for Parkinson's Disease at 2024 ACS Spring Meeting

Brenig Therapeutics, an enterprise within the investment group of Torrey Pines Investments, OrbiMed Advisors, and BioGeneration Ventures, specializes in therapies for neurodegenerative conditions. At the American Chemical Society's Spring 2024 event held at the Ernest N. Morial Convention Center in New Orleans, on the 17th of March, new safety information was unveiled for their investigative LRRK2 antagonist medication.

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Brenig has made notable progress in pioneering a sophisticatedly engineered inhibitor targeting LRRK2, labeled BT-0267, which aligns with their goal of tackling neurodegenerative disorders. LRRK2 is a pivotal enzyme connected to the onset of Parkinson's disease and has presented considerable obstacles in drug development.

The company's advanced research has yielded a drug candidate that boasts impressive efficacy in crossing the blood-brain barrier, while reducing unwanted effects outside the central nervous system, and exhibiting an enhanced safety margin.

Recent results underscore the distinguished safety standing of the LRRK2 Inhibitor BT-0267, evidenced by an outstanding cerebral spinal fluid (CSF) to plasma concentration ratio. Additionally, in vivo studies suggest BT-0267 has notable brain activity without detectable structural damage to lungs or kidneys, relative to other LRRK2 inhibitor contenders. Anticipations are set for BT-0267 to embark on phases of human testing by the year-end of 2024.

The pioneering work behind Brenig's top-tier LRRK2 inhibitor, geared towards altering the progression of Parkinson's for patients, including those with sporadic PD forms, has been bolstered by the sophisticated methods of computer-aided drug discovery and the profound knowledge in structural biology provided through the Expert Systems Accelerator.

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According to the data provided by the Synapse Database, As of March 20, 2024, there are 48 investigational drugs for the LRRK2 target, including 17 indications, 46 R&D institutions involved, with related clinical trials reaching 20, and as many as 2936 patents.

BT-0267 targets LRRK2 and has potential applications in treating nervous system diseases and endocrinology and metabolic diseases. The active indication for BT-0267 is Parkinson's disease. However, it is important to note that BT-0267 is currently in the preclinical phase of development, and further research and testing are required before its efficacy and safety can be determined.