Facial Palsy, Congenital, Unilateral or Bilateral

Last update 01 Nov 2024

Basic Info

Synonyms

FACIAL PALSY, CONGENITAL, UNILATERAL OR BILATERAL, Facial Palsy, Congenital, Unilateral Or Bilateral, 面神经麻痹，先天性，单侧或双侧

Introduction-

100 Clinical Results associated with Facial Palsy, Congenital, Unilateral or Bilateral

100 Translational Medicine associated with Facial Palsy, Congenital, Unilateral or Bilateral

0 Patents (Medical) associated with Facial Palsy, Congenital, Unilateral or Bilateral

Literatures (Medical) associated with Facial Palsy, Congenital, Unilateral or Bilateral

01 Jul 2017·Journal of Cranio-Maxillofacial SurgeryQ3 · MEDICINE

Masseteric nerve for gracilis muscle re-innervation in unilateral facial palsy: Impact on quality of life

Q3 · MEDICINE

Article

Author: Ferrari, S ; Sesenna, E ; Bergonzani, M ; Pedrazzi, G ; Ferri, A ; Poddi, V ; Bianchi, B

BACKGROUNDUnilateral established or congenital facial palsies are usually treated with neuromuscular transplantation to reanimate the impaired side of the face. One of the most debated points is the motor nerve to choose for the reinnervation of the transplant. Contra-lateral healthy facial nerve is usually preferred, but in selected cases motor nerve to masseter is considered a valuable option. However only a few clinical studies focused on quality of life in this subset of patients are available in literature.METHODSTwenty patients treated for established or congenital unilateral facial palsy reanimated with gracilis muscle transplant reinnervated with masseteric nerve were retrospectively analyzed. The FDI questionnaire on quality of life was administered before and after surgery and statistical analysis of results was conducted to score changes.RESULTSOverall results of the questionnaire resulted in a statistically significant improvement after surgery, with a p value of 0.05.CONCLUSIONFacial animation with gracilis muscle transplant re-innervated with masseteric nerve is a safe and reliable procedure in selected unilateral facial palsy patients. Results reported here confirm that surgery mainly improves the functional aspects of a patient's daily life quality, while the impact on social interactions and self-perception is less significant. The comparison of these results with those obtained in patients treated with gracilis muscle transplant re-innervated via contralateral facial nerve suggests that spontaneity is probably highly relevant to improve social aspects of QOL in this subset of patients.

01 Mar 2017·Molecular Case Studies

An exome sequencing study of Moebius syndrome including atypical cases reveals an individual with CFEOM3A and aTUBB3mutation

Article

Author: Lupski, James R ; Liu, David ; Lu, James T ; Fernbach, Susan D ; Campeau, Philippe M ; Gibbs, Richard A ; Gonzaga-Jauregui, Claudia ; Lalani, Seema R ; Belmont, John W ; Jhangiani, Shalini ; Lee, Brendan H ; Muzny, Donna ; Paysse, Evelyn A ; Edmond, Jane C ; Patel, Ronak M ; Sutton, V Reid ; Azamian, Mahshid ; White, Lisa ; Lewis, Richard Alan

Moebius syndrome is characterized by congenital unilateral or bilateral facial and abducens nerve palsies (sixth and seventh cranial nerves) causing facial weakness, feeding difficulties, and restricted ocular movements. Abnormalities of the chest wall such as Poland anomaly and variable limb defects are frequently associated with this syndrome. Most cases are isolated; however, rare families with autosomal dominant transmission with incomplete penetrance and variable expressivity have been described. The genetic basis of this condition remains unknown. In a cohort study of nine individuals suspected to have Moebius syndrome (six typical, three atypical), we performed whole-exome sequencing to try to identify a commonly mutated gene. Although no such gene was identified and we did not find mutations inPLXND1andREV3L, we found a de novo heterozygous mutation, p.E410K, in the gene encoding tubulin beta 3 class III (TUBB3), in an individual with atypical Moebius syndrome. This individual was diagnosed with near-complete ophthalmoplegia, agenesis of the corpus callosum, and absence of the septum pellucidum. No substantial limb abnormalities were noted. Mutations inTUBB3have been associated with complex cortical dysplasia and other brain malformations and congenital fibrosis of extraocular muscles type 3A (CFEOM3A). Our report highlights the overlap of genetic etiology and clinical differences between CFEOM and Moebius syndrome and describes our approach to identifying candidate genes for typical and atypical Moebius syndrome.

01 Jan 2014·Genetic counseling (Geneva, Switzerland)

Electroconvulsive therapy during pregnancy as a possible cause of Möbius syndrome: additional clinical observation.

Article

Author: Cetin, H ; Sandal, G

Möbius syndrome is a rare congenital disease with a prevalence of between 0.0002 and 0.002% of births. Minimum diagnostic criteria for this disease include congenital unilateral or bilateral facial and abducens nerve paresis. Occasionally, the cranial nerves V and VIII are affected. If cranial VIII is affected, the person experiences hearing loss. Other findings in these patients that are not part of the diagnostic criteria include the involvement of other cranial nerves, malformations of orofacial structures, reductive limb anomalies, and defects of the chest wall. We herein report a newborn case with Möbius syndrome.

Analysis

Perform a panoramic analysis of this field.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Facial Palsy, Congenital, Unilateral or Bilateral

Basic Info

Related

Analysis