Tonsil and/or adenoid hypertrophy

Last update 08 May 2025

Basic Info

Synonyms

Adenotonsillar hypertrophy, Enlargement of tonsil or adenoid, Enlargement of tonsil or adenoid (disorder)

+ [22]

Introduction-

Clinical Trials associated with Tonsil and/or adenoid hypertrophy

ChiCTR2500099650

/ SuspendedEarly Phase 1IIT

Application of virtual reality in pain management after tonsillectomy in children

Start Date01 Apr 2025

Sponsor / Collaborator-

CTRI/2024/08/071825

/ Not yet recruitingNot ApplicableIIT

A randomized controlled study to evaluate effectiveness of propofol administered at the end of the surgery for prevention of emergence agitation in children undergoing adenotonsillectomy in department of anaesthesia, SMS Medical College, Jaipur. - nil

Start Date16 Aug 2024

Sponsor / Collaborator-

ChiCTR2400086998

/ SuspendedPhase 4IIT

Effect of Intranasal Remimazolam besylate for Premedication on the Occurrence of Respiratory Adverse Events in Children Undergoing Tonsillectomy and Adenoidectomy:A Single-blind Randomized Controlled Study

Start Date17 Jul 2024

Sponsor / Collaborator-

100 Clinical Results associated with Tonsil and/or adenoid hypertrophy

100 Translational Medicine associated with Tonsil and/or adenoid hypertrophy

0 Patents (Medical) associated with Tonsil and/or adenoid hypertrophy

1,150

Literatures (Medical) associated with Tonsil and/or adenoid hypertrophy

17 Apr 2025·Journal of sleep research

Prevalence of Altered Craniofacial Morphology in Children With OSA.

Article

Author: Amin, Reshma ; Pliska, Benjamin ; Jacob, Sheila ; Cholette, Marie-Claude ; Vezina, Kevin ; Narang, Indra ; Zhang, Jingjing ; Laberge, Sophie ; Almeida, Fernanda ; Huynh, Nelly ; Hamoda, Mona ; Montpetit, Andrée ; Kirk, Val ; Chadha, Neil

Snoring and obstructive sleep apnoea (OSA) affect a significant percentage of children. Recent studies have suggested that altered craniofacial morphology may contribute to the multifactorial pathophysiology of OSA. This study aims to determine the prevalence of craniofacial abnormalities and malocclusion in children referred for polysomnography due to OSA suspicion. This is a multicentre prevalence study completed across four Canadian sites. Otherwise, healthy children (≥ 4 years old) who were seen at the sleep clinic were recruited. Upon arrival for their hospital-based overnight sleep recording, a clinical orthodontic assessment and a series of paediatric sleep questionnaires were completed for each participant. Data from 315 children (age 9.37 ± 3.70) revealed significant risk factors associated with the presence of OSA, including male sex, presence of snoring, endomorph body type, and hypertrophic tonsils. The intra-oral and facial morphologic characteristics were not significantly different between children with (AHI 9.51 ± 10.94) and without (AHI 0.84 ± 0.50) PSG-verified OSA. Factors such as maxillary constriction/posterior crossbite and a retrognathic mandible showed similar (p > 0.05) prevalence between groups. Hierarchical regression analysis showed no statistically significant facial and dental variables in predicting AHI. In conclusion, a multidisciplinary approach involving dental professionals with expertise in growth and development is crucial for the assessment of possible craniofacial abnormalities in children with OSA. Craniofacial morphology may play a limited role in the pathophysiology of OSA in most children, as no differences in the prevalence of these variables in children with and without OSA were found in this large, multicentre study.

01 Apr 2025·Sleep Medicine

Association of sleep disordered breathing with severity and control of persistent asthma in Indian children

Article

Author: Bagla, Jyoti ; Singla, Aarushi ; Dubey, Anand Prakash ; Kumari, Sweta ; Gothi, Dipti

OBJECTIVETo assess the association of pediatric sleep disordered breathing (SDB) with control and severity of asthma, and to evaluate the comorbidities associated with both.METHODSBased on the Sleep-Related Breathing Disorder scale, extracted from the Pediatric Sleep Questionnaire (SDBS-PSQ), children (5-15 years) with persistent asthma were classified as; with SDB (SDBS-PSQ≥0.33) and without SDB (SDBS-PSQ<0.33), in a cross-sectional study. Baseline characteristics were compared. Control of asthma into well-controlled, not-well, and poorly controlled was assessed using childhood - asthma control test (c-ACT). Comorbidities like adeno-tonsillar hypertrophy, gastroesophageal reflux disease (GERD), obesity and allergic rhinitis (AR) for presence of SDB in asthma were assessed.RESULTSSixty asthmatics were included. Mild, moderate, and severe persistent asthma was observed in 26.67 %, 40 % and 33.33 % respectively, with 18.33 % asthmatics having SDB. 42.3 % of uncontrolled asthmatics had SDB. Baseline characteristics were similar in both groups. Asthmatics with SDB had higher frequency of severe persistent (63.6 % vs 26.5 %, p = 0.018) and uncontrolled asthma i.e. partly & poorly controlled (100 % vs 30.6 %, p < 0.001) versus asthmatics without SDB. Mean SDBS-PSQ score was higher in uncontrolled asthmatics compared to well-controlled asthmatics (0.255 ± 0.19 vs 0.047 ± 0.06, p < 0.001). Mean c-ACT score was lower with SDB (14.45 ± 3.20 vs 20.04 ± 4.56, p < 0.001), indicating poor control of asthma. A negative relationship was established between c-ACT and SDBS-PSQ (p < 0.001, r² = -0.36). Higher occurrence of AR was found in asthmatics with SDB (72.7 % vs 20.4 %, p = 0.001).CONCLUSIONSDB may be associated with poor control and worsening severity of asthma. Concomitant AR was found in asthmatic children with SDB.

01 Apr 2025·Minerva Dental and Oral Science

Effects of rapid maxillary expansion in pediatric patients affected by obstructive sleep apnea syndrome: a literature review

Review

Author: Portelli, Marco ; Galletti, Fulvia ; Maio, Alessandra ; Nucera, Riccardo ; Bellocchio, Angela M ; Fiorillo, Luca ; Militi, Angela

INTRODUCTIONObstructive sleep apnea syndrome (OSAS) is a breathing disorder during sleep, characterized by upper airway obstruction with many subsequent daytime and nocturnal symptoms. Children with OSAS may show abnormalities of the maxillary structure. This review aims to evaluate the effectiveness of rapid maxillary expansion (RME) as a treatment for OSAS in children to reduce apnea/hypopnea index and oxygen saturation.EVIDENCE ACQUISITIONAn electronic search for all articles published in English from January 2004 to February 2022. The study focused on children between 5 and 12 years old and meeting the following inclusion criteria: clinical signs of malocclusion, no syndromic children, adenotonsillar hypertrophy, underwent an otolaryngology evaluation and no previous treatment for OSAS. The device was fixed to the second deciduous molars. After 12 months, the RME was removed.EVIDENCE SYNTHESISThe investigation recorded a statistically significant reduction in AHI (apnea/hypopnea index) (on average 60-65%) and an increase in oxygen saturation ranging from 95% to 97%.CONCLUSIONSThis review shows that RME, through the enlargement of dental arches and nasal-maxillary structures, may be a helpful approach in children with malocclusion and OSAS.

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