Peripheral Arterial Occlusive Disease 1

-- VAZKEPA® (icosapent ethyl) accepted by the Scottish Medicines Consortium (SMC) for restricted use within NHSScotland, as secondary prevention in adult statin-treated patients at high cardiovascular risk1 -- -- VAZKEPA® already commercially available in England, Wales, and Northern Ireland where NICE recommended its reimbursement and use across the National Health Service (NHS) in July 2022 -- -- Amarin now working with Health Boards across Scotland to secure formulary inclusion and ensure eligible population access to VAZKEPA® by end of 2023 -- DUBLIN, Ireland and BRIDGEWATER, N.J., Aug. 07, 2023 (GLOBE NEWSWIRE) -- Amarin Corporation plc (NASDAQ:AMRN) today announces that the Scottish Medicines Consortium (SMC) has accepted VAZKEPA® (icosapent ethyl) for reimbursement with a Patient Access Scheme* for secondary prevention in patients treated with a stable dose of statins, low-density lipoprotein (LDL) cholesterol levels >1.04mmol/L and ≤2.60mmol/L, raised fasting triglycerides (≥1.7mmol/L) and with established cardiovascular disease (CVD) defined as a history of any of the following: acute coronary syndrome (ACS) such as myocardial infarction (MI) or unstable angina needing hospitalization; coronary or other arterial revascularization procedures; coronary heart disease; ischaemic stroke; or peripheral arterial disease.1 “The acceptance of icosapent ethyl, an innovative active substance comprising a highly purified omega-3 fatty acid (eicosapentaenoic acid greater or equal to 96%), will provide healthcare professionals in Scotland with an additional treatment option to be considered for eligible patients who are at high risk of a subsequent CV event, such as a second heart attack or stroke. This represents an important step forward in the fight against CVD in Scotland,” said Professor Adrian Brady, Consultant Cardiologist at Glasgow Royal Infirmary. CVD is a significant issue for patients and HCPs in Scotland.2-4 While current therapies can help to reduce the risk of a first or recurrent major cardiovascular event, there are still at least 10,000 hospital admissions for heart attacks each year, which equates to 1 every 50 minutes, with heart and circulatory diseases causing nearly 18,000 (28%) deaths annually in Scotland.3 What’s more, CVD costs NHS Scotland around £800 million each year, with a wider estimated cost to the economy of £1.8 billion.3,4 “The SMC’s acceptance and reimbursement of VAZKEPA® is an important development for patients at high cardiovascular risk in Scotland, who will now have access to an innovative treatment option to improve their outcomes. Our UK team will now be focused on working with health boards to secure formulary inclusion and make VAZKEPA® available to these patients as quickly as possible,” said Patrick Holt, President and CEO of Amarin. Amarin is working with Health Boards across Scotland to secure formulary inclusion and ensure that as many patients as possible among the eligible population will have access to VAZKEPA® by the end of 2023. The Company continues to advance its pricing and reimbursement discussions in a number of other European markets to drive patient access across the region and will share updates as these become available. *Patient Access Schemes are confidential pricing agreements proposed by pharmaceutical companies to enable patient access to new medicines and treatments. The Patient Access Scheme Assessment Group (PASAG) reviews and advises NHSScotland on the feasibility of proposed schemes for implementation. It operates separately from SMC. References Scottish Medicines Consortium. Icosapent Ethyl (SMC2602). https://www.scottishmedicines.org.uk/medicines-advice/icosapent-ethyl-vazkepa-ft-resub-smc2602/. Accessed August 2023.National Institute for Health and Care Excellence. Clinical Knowledge Summary. CVD risk assessment and management: What is the impact of CVD? May 2023. https://cks.nice.org.uk/topics/cvd-risk-assessment-management/background-information/burden-of-cvd/. Accessed August 2023.British Heart Foundation. Scotland Factsheet. BHF. February 2023. https://www.bhf.org.uk/-/media/files/for-professionals/research/heart-statistics/bhf-cvd-statistics-scotland-factsheet.pdf. Accessed August 2023 (from the UK).British Heart Foundation. The CVD Challenge in Scotland. 2018. https://www.bhf.org.uk/for-professionals/healthcare-professionals/data-and-statistics/the-cvd-challenge/the-cvd-challenge-in-scotland. Accessed August 2023. About AmarinAmarin is an innovative pharmaceutical company leading a new paradigm in cardiovascular disease management. We are committed to increasing the scientific understanding of the cardiovascular risk that persists beyond traditional therapies and advancing the treatment of that risk for patients worldwide. Amarin has offices in Bridgewater, New Jersey in the United States, Dublin in Ireland, Zug in Switzerland, and other countries in Europe as well as commercial partners and suppliers around the world. Forward-Looking Statements This press release contains forward-looking statements which are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, including beliefs about the acceptance and reimbursement of VAZKEPA in Scotland; the effect of Amarin’s entry into Scotland and its continued efforts to expand into other key international markets; and the overall potential and future success of VASCEPA (marketed as VAZKEPA in Europe) and Amarin generally. These forward-looking statements are not promises or guarantees and involve substantial risks and uncertainties. A further list and description of these risks, uncertainties and other risks associated with an investment in Amarin can be found in Amarin's filings with the U.S. Securities and Exchange Commission, including Amarin’s annual report on Form 10-K for the full year ended 2022. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date they are made. Amarin undertakes no obligation to update or revise the information contained in its forward-looking statements, whether as a result of new information, future events or circumstances or otherwise. Amarin’s forward-looking statements do not reflect the potential impact of significant transactions the company may enter into, such as mergers, acquisitions, dispositions, joint ventures or any material agreements that Amarin may enter into, amend or terminate. Availability of Other Information About AmarinInvestors and others should note that Amarin communicates with its investors and the public using the company website (www.amarincorp.com), the investor relations website (amarincorp.gcs-web.com), including but not limited to investor presentations and investor FAQs, U.S. Securities and Exchange Commission filings, press releases, public conference calls and webcasts. The information that Amarin posts on these channels and websites could be deemed to be material information. As a result, Amarin encourages investors, the media, and others interested in Amarin to review the information that is posted on these channels, including the investor relations website, on a regular basis. This list of channels may be updated from time to time on Amarin’s investor relations website and may include social media channels. The contents of Amarin’s website or these channels, or any other website that may be accessed from its website or these channels, shall not be deemed incorporated by reference in any filing under the Securities Act of 1933. Amarin Contact InformationInvestor Inquiries:Jordan ZwickAmarin Corporation plcIR@amarincorp.com Media Inquiries:Mark MarmurAmarin Corporation plcPR@amarincorp.com

SINGAPORE, Nov. 11, 2022 /PRNewswire/ -- Genesis MedTech Group announced today that the Food and Drug Administration (FDA) has approved the Chocolate Touch® Drug-coated Balloon PTA Catheter, developed by TriReme Medical LLC, for the treatment of patients with peripheral artery disease in the superficial femoral artery and the popliteal artery. The Chocolate Touch® drug-coated balloon (DCB) was shown to have statically superior patency and non-inferior safety at 12 months as compared with Lutonix® DCB based on a head-to-head, randomized trial of patients with symptomatic femoropopliteal disease[1]. The Chocolate Touch showed statistically superiority in its primary efficacy endpoint of 12-month True DCB Success– a measure of the target vessel remaining patent without the need for bail-out stenting. Primary patency was 78.8% for Chocolate Touch and 67.7% for Lutonix DCB at 12mo (psuperiority=0.0386); by Kaplan-Meier (KM) estimate it was 83.3% for the Chocolate Touch and 73.0% for Lutonix DCB at 12 months[1] The primary safety endpoint of 12-month freedom from major adverse events (MAE) was 88.9% for those treated with the Chocolate Touch versus 84.6% for Lutonix DCB (Pnon-inferiority <0.0001. [1] Chocolate Touch results reported the lowest all-cause KM mortality value as compared to reported mortality for FDA approved DCBs in pivotal studies. Mortality rates for Chocolate Touch using KM estimates at 3 years were 6.7% for the Chocolate Touch and 11.1% for the Lutonix DCB. "I am very excited to see the Chocolate Touch, a next-generation drug coated balloon, is now available for patients across the United States. This technology is an important tool in the armamentarium for the treatment of patients with peripheral artery disease," stated Mehdi H. Shishehbor, DO, MPH, PhD, University Hospitals Harrington Heart & Vascular Institute, Cleveland, OH, the Chocolate Touch trial's Co-Principal Investigator. The Chocolate Touch® drug-coated balloon is the world's first and only balloon catheter that integrates therapeutic agent delivery with the next generation angioplasty platform, for the treatment of peripheral arterial disease. Chocolate Touch® is designed to open in small sections using pillow-like structures coated with a therapeutic agent. With the goal of providing patients suffering from peripheral arterial disease with an alternative treatment to traditional drug-coated balloon angioplasty. "This next generation paclitaxel DCB is based on the Chocolate mechanism of pillow-and-groove formation resulting in an increased balloon surface facilitating effective drug release to the vessel wall and potentially reducing the need for permanent implants. The recently completed randomized, controlled study demonstrated excellent primary results, with statistical superior effectiveness as compared to the control drug coated balloon. The Chocolate Touch is a drug coated balloon category of its own," commented co-principal Investigator Professor Thomas Zeller, Universitaets-Herzzentrum, Bad Krozingen, Germany. Warren Wang, Chairman and CEO of Genesis MedTech Group said, "The Chocolate Touch® FDA approval provides U.S. physicians and their patients a next-generation drug-coated balloon with exceptional safety and efficacy to use in treating patients with PAD. This approval demonstrate our commitment to bring innovation solutions to enhance the standard of care of millions of patients suffering from peripheral vascular diseases." The company is planning to launch this product in the US through its subsidiary, G Vascular. About the Chocolate Touch® Drug-coated Balloon (DCB) The Chocolate Touch® (Paclitaxel Coated PTA Balloon Catheter) is indicated for percutaneous transluminal angioplasty, after appropriate vessel preparation, of de novo or restenotic lesions up to 180 mm in length in native femoral or popliteal arteries with reference vessel diameters of 4.0 mm to 6.0 mm. About Genesis MedTech Group Genesis MedTech Group is a medical device company headquartered in Singapore. Founded by a group of professionals and entrepreneurs with MedTech experience globally and in Asia, the company's product portfolio focuses on multi-therapy medical device products for emerging markets with sales and distribution through its established commercial network. Genesis MedTech Group covers the entire industry value chain of research and development, production, quality management, supply chain, marketing, and sales. For more information, visit About G Vascular Pte Ltd G Vascular is a subsidiary of Genesis MedTech Group, with a focus in developing innovative products for peripheral vascular diseases. Its first technology, the Chocolate Touch® is a next generation drug-coated balloon and the world's first balloon catheter that integrates therapeutic agent delivery with the next generation angioplasty platform, for the treatment of peripheral arterial disease. About PAD[2] Impacting 200 million patients worldwide, peripheral arterial disease (PAD) is a slow and progressive circulation disorder, caused by narrowing, blockage, or spasms in a blood vessel. Arteries in the legs and feet are most commonly affected. Complications of PAD may include amputation (loss of a limb), poor wound healing, restricted mobility due to pain or discomfort, severe pain in the affected extremity, or stroke (3 times more likely in people with PAD). References MH Shishehbor, T Zeller, M Werner, M Brodmann, H Parise, A Holden, M Lichtenberg, SA Parikh, VS Kashyap, C Pietras, D Tirziu, S Ardakani, U Beschorner, P Krishnan, KA Niazi, AU Wali, AJ Lansky. Randomized Trial of Chocolate Touch Compared With Lutonix Drug-Coated Balloon in Femoropopliteal Lesions (Chocolate Touch Study). Circulation. 2022; 145: 1645–1654 Creager MA, Loscalzo J. Chapter 275: Arterial Diseases of the Extremities. In: Jameson J, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J. eds. Harrison's Principles of Internal Medicine. McGraw-Hill; Accessed August 28, 2020. SOURCE Genesis MedTech